Rational Design of Capping Ligands of Quantum Dots for Biosensing

doi:10.1007/s40242-024-4034-4

高等学校化学研究 ›› 2024, Vol. 40 ›› Issue (2): 162-172.doi: 10.1007/s40242-024-4034-4

Rational Design of Capping Ligands of Quantum Dots for Biosensing

XU Xinran, LIU An-an, PANG Daiwen

State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, P. R. China

收稿日期:2024-02-20 修回日期:2024-03-14 出版日期:2024-04-01 发布日期:2024-03-27
通讯作者: LIU An-an ananliu@nankai.edu.cn;PANG Daiwen dwpang@whu.edu.cn
基金资助:
This work was supported by the National Natural Science Foundation of China (Nos. 22293030, 22293032), the National Key Research and Development Program of China (Nos. 2019YFA0210100, 2023YFB3208301), and the Fundamental Research Funds for the Central Universities of China (No. 63211023).

Rational Design of Capping Ligands of Quantum Dots for Biosensing

XU Xinran, LIU An-an, PANG Daiwen

State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, P. R. China

Received:2024-02-20 Revised:2024-03-14 Online:2024-04-01 Published:2024-03-27
Contact: LIU An-an ananliu@nankai.edu.cn;PANG Daiwen dwpang@whu.edu.cn
Supported by:
This work was supported by the National Natural Science Foundation of China (Nos. 22293030, 22293032), the National Key Research and Development Program of China (Nos. 2019YFA0210100, 2023YFB3208301), and the Fundamental Research Funds for the Central Universities of China (No. 63211023).

摘要/Abstract

摘要： Quantum dots have been widely applied in biosensing due to their outstanding optical properties. The emissions of quantum dots are mainly determined by their composition and size, as described by the Brus’s equation. Somehow, in this case, their emissions are hardly regulated reversibly and responsively, which are unsuitable for biosensing and biodetection. In the last decade, capping ligands have been used for designing biosensors because of their responsive regulation on the photoluminescence of quantum dots. Here, we first summarize the advances in characterization and calculation specific for ligands, which have helped to provide insights into the photoluminescence process and energy band theory of quantum dots. We then review two ways of ligand design that influence the optical properties of quantum dots: affecting the process of photoluminescence, or the orbital/ electronic structure. In the latter case, the atoms on both the ligand and the surface of the quantum dot interact to affect the energy band structure of the quantum dot core. Examples are presented of how these quantum dots that possess responsive properties due to the design of the ligands have been applied to sensing. With further exploration, we hope to see advances in the fundamental understanding of the energy band structures and practical applications of these quantum dots.

关键词: Quantum dot, Ligand, Photoluminescence, Responsiveness, Sensor

Abstract: Quantum dots have been widely applied in biosensing due to their outstanding optical properties. The emissions of quantum dots are mainly determined by their composition and size, as described by the Brus’s equation. Somehow, in this case, their emissions are hardly regulated reversibly and responsively, which are unsuitable for biosensing and biodetection. In the last decade, capping ligands have been used for designing biosensors because of their responsive regulation on the photoluminescence of quantum dots. Here, we first summarize the advances in characterization and calculation specific for ligands, which have helped to provide insights into the photoluminescence process and energy band theory of quantum dots. We then review two ways of ligand design that influence the optical properties of quantum dots: affecting the process of photoluminescence, or the orbital/ electronic structure. In the latter case, the atoms on both the ligand and the surface of the quantum dot interact to affect the energy band structure of the quantum dot core. Examples are presented of how these quantum dots that possess responsive properties due to the design of the ligands have been applied to sensing. With further exploration, we hope to see advances in the fundamental understanding of the energy band structures and practical applications of these quantum dots.

Key words: Quantum dot, Ligand, Photoluminescence, Responsiveness, Sensor

XU Xinran, LIU An-an, PANG Daiwen. Rational Design of Capping Ligands of Quantum Dots for Biosensing[J]. 高等学校化学研究, 2024, 40(2): 162-172.

XU Xinran, LIU An-an, PANG Daiwen. Rational Design of Capping Ligands of Quantum Dots for Biosensing[J]. Chemical Research in Chinese Universities, 2024, 40(2): 162-172.

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Rational Design of Capping Ligands of Quantum Dots for Biosensing

Rational Design of Capping Ligands of Quantum Dots for Biosensing

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