Synthesis and Characterization of Novel Azo-containing or Azoxy-containing Schiff Bases and Their Antiproliferative and Cytotoxic Activities

doi:10.1007/s40242-015-4355-4

高等学校化学研究 ›› 2015, Vol. 31 ›› Issue (1): 60-64.doi: 10.1007/s40242-015-4355-4

Synthesis and Characterization of Novel Azo-containing or Azoxy-containing Schiff Bases and Their Antiproliferative and Cytotoxic Activities

SU Ran¹, LÜ Lei¹, ZHENG Songzhi¹, JIN Yinghua², AN Shengji¹

1. College of Chemistry, Changchun 130012, P. R. China;
2. College of Life Science, Jilin University, Changchun 130012, P. R. China

收稿日期:2014-09-23 修回日期:2014-11-06 出版日期:2015-02-01 发布日期:2015-01-21
通讯作者: AN Shengji, E-mail:anshengji@jlu.edu.cn E-mail:anshengji@jlu.edu.cn

Synthesis and Characterization of Novel Azo-containing or Azoxy-containing Schiff Bases and Their Antiproliferative and Cytotoxic Activities

SU Ran¹, LÜ Lei¹, ZHENG Songzhi¹, JIN Yinghua², AN Shengji¹

1. College of Chemistry, Changchun 130012, P. R. China;
2. College of Life Science, Jilin University, Changchun 130012, P. R. China

Received:2014-09-23 Revised:2014-11-06 Online:2015-02-01 Published:2015-01-21
Contact: AN Shengji, E-mail:anshengji@jlu.edu.cn E-mail:anshengji@jlu.edu.cn

摘要/Abstract

摘要：

A series of novel Schiff base derivatives was designed and synthesized from 3,3'-azobenzaldehyde and 3,3'-azoxybenzaldehyde. The newly synthesized compounds were characterized by FTIR, ¹H NMR, MS and elemental analysis and tested for their in vitro antiproliferative activities against HeLa cell lines. At the same time, the impact on the antitumor activity of the sulfanilamido, benzamido, phenolic hydroxyl or thiourea groups was investigated and discussed. Compounds 4, 6 and 10 were found to exhibit strong cytotoxic activity.

关键词: Schiff base, Azo, Azoxy, Anti-proliferative activity, Cytotoxic activity

Abstract:

Key words: Schiff base, Azo, Azoxy, Anti-proliferative activity, Cytotoxic activity

SU Ran, LÜ Lei, ZHENG Songzhi, JIN Yinghua, AN Shengji. Synthesis and Characterization of Novel Azo-containing or Azoxy-containing Schiff Bases and Their Antiproliferative and Cytotoxic Activities[J]. 高等学校化学研究, 2015, 31(1): 60-64.

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Synthesis and Characterization of Novel Azo-containing or Azoxy-containing Schiff Bases and Their Antiproliferative and Cytotoxic Activities

Synthesis and Characterization of Novel Azo-containing or Azoxy-containing Schiff Bases and Their Antiproliferative and Cytotoxic Activities

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