Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery

doi:10.1007/s40242-019-0049-7

高等学校化学研究 ›› 2020, Vol. 36 ›› Issue (2): 274-280.doi: 10.1007/s40242-019-0049-7

Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery

PAN Gaifang¹, MA Yuan¹, ZHANG Jiao¹, GUO Yuanyuan¹, DING Fei¹, GE Huan¹, LI Qifeng², ZHU Xinyuan¹, ZHANG Chuan¹

1. School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, Shanghai 200240, P. R. China;
2. Department of Paediatric Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, P. R. China

收稿日期:2019-11-12 修回日期:2019-12-04 出版日期:2020-04-01 发布日期:2020-03-18
通讯作者: LI Qifeng, ZHANG Chuan E-mail:chuanzhang@sjtu.edu.cn;lqf989@163.com
基金资助:
Supported by the National Key Research and Development Program of China(Nos.2018YFC1106100, 2018YFC1106102), the National Natural Science Foundation of China(Nos.21661162001, 21673139, 51690151, 51473093, 51973112), the Special Program for Collaborative Innovation in Shanghai University of Medicine & Health Sciences, China(No.SPCI-17-15-001) and the Program of Shanghai Medical Professionals Across Subject Funds, China(No.YG2016MS74).

Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery

PAN Gaifang¹, MA Yuan¹, ZHANG Jiao¹, GUO Yuanyuan¹, DING Fei¹, GE Huan¹, LI Qifeng², ZHU Xinyuan¹, ZHANG Chuan¹

1. School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, Shanghai 200240, P. R. China;
2. Department of Paediatric Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, P. R. China

Received:2019-11-12 Revised:2019-12-04 Online:2020-04-01 Published:2020-03-18
Contact: LI Qifeng, ZHANG Chuan E-mail:chuanzhang@sjtu.edu.cn;lqf989@163.com
Supported by:
Supported by the National Key Research and Development Program of China(Nos.2018YFC1106100, 2018YFC1106102), the National Natural Science Foundation of China(Nos.21661162001, 21673139, 51690151, 51473093, 51973112), the Special Program for Collaborative Innovation in Shanghai University of Medicine & Health Sciences, China(No.SPCI-17-15-001) and the Program of Shanghai Medical Professionals Across Subject Funds, China(No.YG2016MS74).

摘要/Abstract

摘要： Herein, we report a geometrically well-defined prism assembled by two floxuridine(F) integrated RNA strands as a precise nanomedicine for chemodrug delivery. Owing to the similarity between chemotherapeutic F and uridine(U), all uridines in the component RNA strands are replaced by F during their in vitro transcription syntheses. By specifically designing their sequences, F-containing S-shape tiles with the single-stranded loops are constructed and then further assemble into the RNA prism through T-junction interactions and sticky-end cohesions. The present study demonstrates that the F-integrated RNA prism can serve as an efficient platform for chemodrug delivery and anticancer treatment. We believe that the study would help the future development of RNA-based nanomedicine in various applications.

关键词: Self-assembly, Floxuridine, RNA prism, Precise nanodrug, Drug delivery

Abstract: Herein, we report a geometrically well-defined prism assembled by two floxuridine(F) integrated RNA strands as a precise nanomedicine for chemodrug delivery. Owing to the similarity between chemotherapeutic F and uridine(U), all uridines in the component RNA strands are replaced by F during their in vitro transcription syntheses. By specifically designing their sequences, F-containing S-shape tiles with the single-stranded loops are constructed and then further assemble into the RNA prism through T-junction interactions and sticky-end cohesions. The present study demonstrates that the F-integrated RNA prism can serve as an efficient platform for chemodrug delivery and anticancer treatment. We believe that the study would help the future development of RNA-based nanomedicine in various applications.

Key words: Self-assembly, Floxuridine, RNA prism, Precise nanodrug, Drug delivery

PAN Gaifang, MA Yuan, ZHANG Jiao, GUO Yuanyuan, DING Fei, GE Huan, LI Qifeng, ZHU Xinyuan, ZHANG Chuan. Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery[J]. 高等学校化学研究, 2020, 36(2): 274-280.

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Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery

Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery

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