Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning

doi:10.1007/s40242-020-0225-9

高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (3): 411-418.doi: 10.1007/s40242-020-0225-9

Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning

HUANG Libing¹, LIU Yueqi¹, SANG Xinyu², SONG Jinghui¹, HU Ping², LIU Yong²

1. College of Mechanical and Electric Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China;
2. Beijing Key Laboratory of Advanced Functional Polymer Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China

收稿日期:2020-07-03 修回日期:2020-09-02 出版日期:2021-06-01 发布日期:2020-09-05
通讯作者: LIU Yong E-mail:yongliu@mail.buct.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(No.21374008).

Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning

HUANG Libing¹, LIU Yueqi¹, SANG Xinyu², SONG Jinghui¹, HU Ping², LIU Yong²

1. College of Mechanical and Electric Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China;
2. Beijing Key Laboratory of Advanced Functional Polymer Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China

Received:2020-07-03 Revised:2020-09-02 Online:2021-06-01 Published:2020-09-05
Contact: LIU Yong E-mail:yongliu@mail.buct.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.21374008).

摘要/Abstract

摘要： The alum-borneol nanoemulsion(ABN), which combines the mineral medicine alum and the botanical medicine borneol, has been applied for approximately 40 years in the clinical treatment of burns, scalds, radiation dermatitis and shingles, and has a good curative effect. However, the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation, which greatly affects the efficacy of the drug. In this study, polyvinylpyrrolidone(PVP) was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF) by electrospinning. The results showed that the stable system with good drug dispersion was 2:3(alum:borneol). The dissolution content of borneol from the ABPF was about 80% in 4 h, which was much higher than that of the alum-borneol liquid(ABL) and ABN. The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN. The composite fiber markedly increased the drug content of borneol, which was 800 times of that in ABN. The fiber had a higher solubility than the nanoemulsion in vitro, which is of great importance for the de-velopment of new forms for the clinical application of alum and borneol.

关键词: Drug delivery, Dissolution content, Bioavailability, Antibacterial, Fiber membrane

Abstract: The alum-borneol nanoemulsion(ABN), which combines the mineral medicine alum and the botanical medicine borneol, has been applied for approximately 40 years in the clinical treatment of burns, scalds, radiation dermatitis and shingles, and has a good curative effect. However, the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation, which greatly affects the efficacy of the drug. In this study, polyvinylpyrrolidone(PVP) was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF) by electrospinning. The results showed that the stable system with good drug dispersion was 2:3(alum:borneol). The dissolution content of borneol from the ABPF was about 80% in 4 h, which was much higher than that of the alum-borneol liquid(ABL) and ABN. The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN. The composite fiber markedly increased the drug content of borneol, which was 800 times of that in ABN. The fiber had a higher solubility than the nanoemulsion in vitro, which is of great importance for the de-velopment of new forms for the clinical application of alum and borneol.

Key words: Drug delivery, Dissolution content, Bioavailability, Antibacterial, Fiber membrane

HUANG Libing, LIU Yueqi, SANG Xinyu, SONG Jinghui, HU Ping, LIU Yong. Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning[J]. 高等学校化学研究, 2021, 37(3): 411-418.

HUANG Libing, LIU Yueqi, SANG Xinyu, SONG Jinghui, HU Ping, LIU Yong. Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning[J]. Chemical Research in Chinese Universities, 2021, 37(3): 411-418.

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Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning

Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning

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