Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination

doi:10.1007/s40242-019-0028-z

高等学校化学研究 ›› 2020, Vol. 36 ›› Issue (2): 268-273.doi: 10.1007/s40242-019-0028-z

Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination

WANG Congli^1,2, DI Zhenghan^1,2, FAN Zetan¹, LI Lele^1,2

1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China;
2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

收稿日期:2019-10-29 修回日期:2019-12-06 出版日期:2020-04-01 发布日期:2019-12-16
通讯作者: LI Lele E-mail:lilele@nanoctr.cn
基金资助:
Supported by the National Natural Science Foundation of China(Nos.21822401, 21771044) and the Young Thousand Talented Program of China.

Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination

WANG Congli^1,2, DI Zhenghan^1,2, FAN Zetan¹, LI Lele^1,2

1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China;
2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Received:2019-10-29 Revised:2019-12-06 Online:2020-04-01 Published:2019-12-16
Contact: LI Lele E-mail:lilele@nanoctr.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21822401, 21771044) and the Young Thousand Talented Program of China.

摘要/Abstract

摘要： Despite a growing interest in DNA nanomaterials, their simple synthesis remains a challenge. A simple and general strategy for constructing DNA-based nanomaterials by metal ion coordination is reported. The metal-DNA nanoparticles(NPs) could be synthesized with DNA molecules of diverse sequence and various metal ions of intrinsic property, resulting in multifunctional NPs with the combined advantages of both inorganic and DNA building blocks. It is demonstrated that the hybrid metal-DNA NPs could be engineered for magnetic resonance and luminescence imaging, encapsulation of multifarious nucleic acids with controlled ratio, and co-assembly with small drug molecules. Furthermore, because these metal-DNA NPs exhibited enhanced cellular uptake compared to free synthetic DNA, they hold potential for applications in diagnostics and therapeutics.

关键词: DNA nanotechnology, Metal ion coordination, Self-assembly

Abstract: Despite a growing interest in DNA nanomaterials, their simple synthesis remains a challenge. A simple and general strategy for constructing DNA-based nanomaterials by metal ion coordination is reported. The metal-DNA nanoparticles(NPs) could be synthesized with DNA molecules of diverse sequence and various metal ions of intrinsic property, resulting in multifunctional NPs with the combined advantages of both inorganic and DNA building blocks. It is demonstrated that the hybrid metal-DNA NPs could be engineered for magnetic resonance and luminescence imaging, encapsulation of multifarious nucleic acids with controlled ratio, and co-assembly with small drug molecules. Furthermore, because these metal-DNA NPs exhibited enhanced cellular uptake compared to free synthetic DNA, they hold potential for applications in diagnostics and therapeutics.

Key words: DNA nanotechnology, Metal ion coordination, Self-assembly

WANG Congli, DI Zhenghan, FAN Zetan, LI Lele. Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination[J]. 高等学校化学研究, 2020, 36(2): 268-273.

WANG Congli, DI Zhenghan, FAN Zetan, LI Lele. Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination[J]. Chemical Research in Chinese Universities, 2020, 36(2): 268-273.

参考文献 37

[1]	Seeman N. C., Nature, 2003, 421, 427
[2]	Park S. Y., Lytton-Jean A. K., Lee B., Weigand S., Schatz G. C., Mirkin C. A., Nature, 2008, 451, 553
[3]	Kuzyk A., Schreiber R., Fan Z., Pardatscher G., Roller E., Högele A., Simmel F. C., Govorov A. O., Liedl T., Nature, 2012, 483, 311
[4]	Tan W., Donovan M. J., Jiang J., Chem. Rev., 2013, 113, 2842
[5]	Teller C., Willner I., Curr. Opin. Biotechnol., 2010, 21(4), 376
[6]	Liu J., Cao Z., Lu Y., Chem. Rev., 2009, 109, 1948
[7]	Rosi N. L., Giljohann D. A., Thaxton C. S., Lytton-Jean A. K. R., Han M. S., Mirkin C. A., Science, 2006, 312(5776), 1027
[8]	Douglas S. M., Bachelet I., Church G. M., Science, 2012, 335(6070), 831
[9]	Lee J. H., Yigit M. V., Mazumdar D., Lu Y., Adv. Drug Deliv. Rev., 2010, 62(6), 592
[10]	Seeman N. C., J. Theor. Biol., 1982, 99(2), 237
[11]	Mirkin C. A., Letsinger R. L., Mucic R. C., Storhoff J. J., Nature, 1996, 382, 607
[12]	Jones M. R., Seeman N. C., Mirkin C. A., Science, 2015, 347(6224), 1260901
[13]	Rogers W. B., Shih W. M., Manoharan V. N., Nat. Rev. Mat., 2016, 1, 16008
[14]	Rothemund P. W., Nature, 2006, 440, 297
[15]	Cutler J. I., Auyeung E., Mirkin C. A., J. Am. Chem. Soc., 2012, 134(3), 1376
[16]	Simmel S. S., Nickels P. C., Liedl T., Acc. Chem. Res., 2014, 47(6), 1691
[17]	Pinheiro A. V., Han D., Shih W. M., Yan H., Nat. Nanotechnol., 2011, 6, 763
[18]	Yang H., McLaughlin C. K., Aldaye F. A., Hamblin G. D., Rys A. Z., Rouiller I., Sleiman H. F., Nat. Chem., 2009, 1, 390
[19]	Aldaye F. A., Palmer A. L., Sleiman H. F., Science, 2008, 321(5897), 1795
[20]	Avakyan N., Greschner A. A., Aldaye F., Serpell C. J., Toader V., Petitjean A., Sleiman H. F., Nat. Chem., 2016, 8, 368
[21]	Northrop B. H., Zheng Y. R., Chi K. W., Stang P. J., Acc. Chem. Res., 2009, 42(10), 1554
[22]	Cook T. R., Zheng Y. R., Stang P. J., Chem. Rev., 2013, 113, 734
[23]	Fujita M., Tominaga M., Hori A., Therrien B., Acc. Chem. Res., 2005, 38(4), 369
[24]	Holten-Andersen N., Harrington M. J., Birkedal H., Lee B. P., Messersmith P. B., Lee K. Y. C., Waite J. H., Proc. Natl. Acad. Sci. USA, 2011, 108(7), 2651
[25]	Burnworth M., Tang L., Kumpfer J. R., Duncan A. J., Beyer F. L., Fiore G. L., Rowan S. J., Weder C., Nature, 2011, 472, 334
[26]	Zhukhovitskiy A. V., Zhong M., Keeler E. G., Michaelis V. K., Sun J. E. P., Hore M. J. A., Pochan D. J., Griffin R. G., Willard A. P., Johnson J. A., Nat. Chem., 2016, 8, 33
[27]	Furukawa H., Cordova K. E., O’Keeffe M., Yaghi O. M., Science, 2013, 341(6149), 1230444
[28]	Zhou H. C., Long J. R., Yaghi O. M., Chem. Rev., 2012, 112, 673
[29]	Zhou H. C., Kitagawa S., Chem. Soc. Rev., 2014, 43(16), 5415
[30]	Oh M., Mirkin C. A., Nature, 2005, 438, 651
[31]	Spokoyny A. M., Kim D., Sumrein A., Mirkin C. A., Chem. Soc. Rev., 2009, 38, 1218
[32]	Ejima H., Richardson J. J., Liang K., Best J. P., van Koeverden M. P., Such G. K., Cui J., Caruso F., Science, 2013, 341(6142), 154
[33]	Li M., Wang C., Di Z., Li H., Zhang J., Xue W., Zhao M., Zhang K., Zhao Y., Li L., Angew. Chem. Int. Ed., 2019, 58, 1350
[34]	Liu B., Hu F., Zhang J., Wang C., Li L., Angew. Chem. Int. Ed., 2019, 58, 8804
[35]	Liu B., Zhang J., Li L. Chem.-Eur. J., 2019, 25, 13452
[36]	Liu F., He X., Chen H., Zhang J., Zhang H., Wang Z., Nat. Commun., 2015, 6, 8003
[37]	Yeo S. J., Yoon J. G., Hong S. C., Yi A. K., J. Immunol., 2003, 170, 1052

Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination

Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination

可视化

摘要/Abstract

引用本文

使用本文

参考文献 37

相关文章 15

编辑推荐

Metrics

本文评价

[1]	GAO Huimin, SHI Rui, ZHU Youliang, QIAN Hujun and LU Zhongyuan. Coarse-grained Dynamics Simulation in Polymer Systems: from Structures to Material Properties[J]. 高等学校化学研究, 2022, 38(3): 653-670.
[2]	YANG Miao, WANG Wenjing, SU Kongzhao, YUAN Daqiang. Dimeric Calix[4]resorcinarene-based Porous Organic Cages for CO₂/CH₄ Separation[J]. 高等学校化学研究, 2022, 38(2): 428-432.
[3]	QIAO Junyi, LIU Xinyao, ZHANG Lirong, LIU Yunling. Self-assembly of 3p-Block Metal-based Metal-Organic Frameworks from Structural Perspective[J]. 高等学校化学研究, 2022, 38(1): 31-44.
[4]	FENG Enduo, TIAN Yang. Surface-enhanced Raman Scattering of Self-assembled Superstructures[J]. 高等学校化学研究, 2021, 37(5): 989-1007.
[5]	Andy Shun-Hoi CHEUNG, Sammual Yu-Lut LEUNG, Franky Ka-Wah HAU, Vivian Wing-Wah YAM. Supramolecular Self-assembly of Amphiphilic Alkynyl-platinum(II) 2,6-Bis(N-alkylbenzimidazol-2'-yl) pyridine Complexes[J]. 高等学校化学研究, 2021, 37(5): 1079-1084.
[6]	HAN Lin, WANG Yuang, TANG Wantao, LIU Jianbing, DING Baoquan. Bioimaging Based on Nucleic Acid Nanostructures[J]. 高等学校化学研究, 2021, 37(4): 823-828.
[7]	REN Yiqing, LIU Xinlong, GE Huan, GUO Yuanyuan, ZHANG Qiushuang, XIE Miao, WANG Ping, ZHU Xinyuan, ZHANG Chuan. A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery[J]. 高等学校化学研究, 2021, 37(4): 906-913.
[8]	YANG Jia, ZHENG Rui, AN Hongwei, WANG Hao. In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis[J]. 高等学校化学研究, 2021, 37(4): 855-869.
[9]	LIU Zhiyu, LIANG Gaolin, ZHAN Wenjun. In situ Activatable Peptide-based Nanoprobes for Tumor Imaging[J]. 高等学校化学研究, 2021, 37(4): 889-899.
[10]	LI Lun, XUE Xiaoxia, SUN Yimeng, ZHAO Wuduo, LI Tiesheng, LIU Minghua, WU Yangjie. Self-assembly Palladacycle Thiophene Imine Monolayer—Investigating on Catalytic Activity and Mechanism for Coupling Reaction[J]. 高等学校化学研究, 2020, 36(5): 821-828.
[11]	ZHANG Junjie, WANG Can, DUAN Ruomeng, PENG Chencheng, YANG Biao, CAO Nan, ZHANG Haiming, CHI Lifeng. Two-dimensional Molecular Phase Transition of Alkylated-TDPB on Au(111) and Cu(111) Surfaces[J]. 高等学校化学研究, 2020, 36(4): 685-689.
[12]	LIU Shengtang, YANG Miao, LIU Cheng, TIAN Bailin, DING Mengning. Superlattice Structure from Re-stacked NiFe Layer Double Hydroxides for Oxygen Evolution Reaction[J]. 高等学校化学研究, 2020, 36(4): 680-684.
[13]	LI Xue, YANG Donglei, SHEN Luyao, XU Fan, WANG Pengfei. Programmable Assembly of DNA-protein Hybrid Structures[J]. 高等学校化学研究, 2020, 36(2): 211-218.
[14]	YIN Jue, WANG Junke, NIU Renjie, REN Shaokang, WANG Dexu, CHAO Jie. DNA Nanotechnology-based Biocomputing[J]. 高等学校化学研究, 2020, 36(2): 219-226.
[15]	LI Tao, DUAN Ruilin, DUAN Zhijuan, HUANG Fujian, XIA Fan. Fluorescence Signal Amplification Strategies Based on DNA Nanotechnology for miRNA Detection[J]. 高等学校化学研究, 2020, 36(2): 194-202.