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高等学校化学研究 ›› 2001, Vol. 17 ›› Issue (3): 243-248.

• Articles • 上一篇    下一篇

Studies on the Interaction of Cobalt Mixed-Ligand Coordination Compound Containing Tetrapyrido [3,2-a: 2′ 3′-c: 3″ 2″ h: 2′″, 3′″-j] phenazine with DNA

SONG Yu-fei, YANG Pin   

  1. Institute of Molecular Science, Shanxi University, Taiyuan 030006, P. R. China
  • 收稿日期:2000-05-19 出版日期:2001-08-24 发布日期:2011-08-04
  • 基金资助:

    Supported by the National Natural Foundation of China and Shanxi Province.

Studies on the Interaction of Cobalt Mixed-Ligand Coordination Compound Containing Tetrapyrido [3,2-a: 2′ 3′-c: 3″ 2″ h: 2′″, 3′″-j] phenazine with DNA

SONG Yu-fei, YANG Pin   

  1. Institute of Molecular Science, Shanxi University, Taiyuan 030006, P. R. China
  • Received:2000-05-19 Online:2001-08-24 Published:2011-08-04
  • Supported by:

    Supported by the National Natural Foundation of China and Shanxi Province.

PDF (PC)

摘要： A new monometallic complex [Co(phen)2tpphz]3+ (where tpphz is tetrapyrido [3,2-a: 2′,3′-c: 3″,2″-h: 2′″,3′″-j] phenazine) was synthesized by the reaction of 5,6-diamino-1,10-phenanthroline with [Co(phen)2(phendione)]3+.It was characterized by elemental analysis, molar conductivity, IR, 1H NMR, ultraviolet and fluorescence spectroscopy.The interaction of the complex with DNA was also investigated.The complex shows the absorption hypochromicity, fluorescence enhancement, the specific viscosity increased when bound to calf thymus DNA.The cyclic voltammetry (CV) measurement showed a change in peak current with the addition of DNA.All the results provide the support for the intercalative binding mode of the mononuclear complex.

关键词: Tetrapyrido [3, 2-a:2&prime, 3&prime, -c:3&Prime, 2&Prime, -h:2&prime, &Prime, 3&prime, &Prime, -j] phenazine, Cobalt, Calf thymus DNA, Intercalative, Binding mode

Abstract: A new monometallic complex [Co(phen)2tpphz]3+ (where tpphz is tetrapyrido [3,2-a: 2′,3′-c: 3″,2″-h: 2′″,3′″-j] phenazine) was synthesized by the reaction of 5,6-diamino-1,10-phenanthroline with [Co(phen)2(phendione)]3+.It was characterized by elemental analysis, molar conductivity, IR, 1H NMR, ultraviolet and fluorescence spectroscopy.The interaction of the complex with DNA was also investigated.The complex shows the absorption hypochromicity, fluorescence enhancement, the specific viscosity increased when bound to calf thymus DNA.The cyclic voltammetry (CV) measurement showed a change in peak current with the addition of DNA.All the results provide the support for the intercalative binding mode of the mononuclear complex.

Key words: Tetrapyrido [3,2-a:2′,3′-c:3″,2″-h:2′″,3′″-j] phenazine, Cobalt, Calf thymus DNA, Intercalative, Binding mode