Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives

高等学校化学研究 ›› 2010, Vol. 26 ›› Issue (6): 937-941.

Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives

CHEN Jiao, MA Zhen and YAN Chao-guo*

College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China

收稿日期:2009-12-14 修回日期:2010-08-16 出版日期:2010-11-25 发布日期:2010-12-01
通讯作者: YAN Chao-guo E-mail:cgyan@yzu.edu.cn
作者简介:YAN Chao-guo. E-mail: cgyan@yzu.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(No.20972132).

Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives

CHEN Jiao, MA Zhen and YAN Chao-guo*

College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China

Received:2009-12-14 Revised:2010-08-16 Online:2010-11-25 Published:2010-12-01
Contact: YAN Chao-guo E-mail:cgyan@yzu.edu.cn
About author:YAN Chao-guo. E-mail: cgyan@yzu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.20972132).

摘要/Abstract

摘要： The three-component reaction of aromatic aldehyde, malononitrile and aliphatic amine in a mixed solvent of methanol and water exhibited very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines, 2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used.

关键词: Multicomponent reaction, Malononitrile, Aldehyde, Dihydropyridine, Pyridine, Aminopyridine

Abstract: The three-component reaction of aromatic aldehyde, malononitrile and aliphatic amine in a mixed solvent of methanol and water exhibited very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines, 2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used.

Key words: Multicomponent reaction, Malononitrile, Aldehyde, Dihydropyridine, Pyridine, Aminopyridine

CHEN Jiao, MA Zhen and YAN Chao-guo*. Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives[J]. 高等学校化学研究, 2010, 26(6): 937-941.

CHEN Jiao, MA Zhen and YAN Chao-guo*. Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives[J]. Chemical Research in Chinese Universities, 2010, 26(6): 937-941.

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Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives

Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives

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