Functional Peptides from One-bead One-compound High-throughput Screening Technique

doi:10.1007/s40242-023-2356-2

高等学校化学研究 ›› 2023, Vol. 39 ›› Issue (1): 83-91.doi: 10.1007/s40242-023-2356-2

Functional Peptides from One-bead One-compound High-throughput Screening Technique

YAN Yaqiong^1,2, WANG Lei^1,2, WANG Hao^1,2

1. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology(NCNST), Beijing, 100190, P. R. China;
2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China

收稿日期:2022-12-21 出版日期:2023-02-01 发布日期:2023-02-02
通讯作者: WANG Hao E-mail:wanghao@nanoctr.cn
基金资助:
This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000) and the National Natural Science Foundation of China(Nos.8201101351, 51890891, 51890892, 51890894).

Functional Peptides from One-bead One-compound High-throughput Screening Technique

YAN Yaqiong^1,2, WANG Lei^1,2, WANG Hao^1,2

1. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology(NCNST), Beijing, 100190, P. R. China;
2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China

Received:2022-12-21 Online:2023-02-01 Published:2023-02-02
Contact: WANG Hao E-mail:wanghao@nanoctr.cn
Supported by:
This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000) and the National Natural Science Foundation of China(Nos.8201101351, 51890891, 51890892, 51890894).

摘要/Abstract

摘要： Combinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC) high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest. The OBOC peptide library screening involves three main steps: library construction, positive beads separation, and peptide sequencing. This review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique.

关键词: Combinatorial chemistry, One-bead one-compound (OBOC), Cyclic peptide, Peptide screening, Self-assembly

Abstract: Combinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC) high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest. The OBOC peptide library screening involves three main steps: library construction, positive beads separation, and peptide sequencing. This review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique.

Key words: Combinatorial chemistry, One-bead one-compound (OBOC), Cyclic peptide, Peptide screening, Self-assembly

YAN Yaqiong, WANG Lei, WANG Hao. Functional Peptides from One-bead One-compound High-throughput Screening Technique[J]. 高等学校化学研究, 2023, 39(1): 83-91.

YAN Yaqiong, WANG Lei, WANG Hao. Functional Peptides from One-bead One-compound High-throughput Screening Technique[J]. Chemical Research in Chinese Universities, 2023, 39(1): 83-91.

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Functional Peptides from One-bead One-compound High-throughput Screening Technique

Functional Peptides from One-bead One-compound High-throughput Screening Technique

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