Engineering Mechanical Strong Biomaterials Inspired by Structural Building Blocks in Nature

doi:10.1007/s40242-023-2357-1

高等学校化学研究 ›› 2023, Vol. 39 ›› Issue (1): 92-106.doi: 10.1007/s40242-023-2357-1

Engineering Mechanical Strong Biomaterials Inspired by Structural Building Blocks in Nature

LI Jiahe¹, MA Chao¹, ZHANG Hongjie^1,2, LIU Kai¹

1. Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China;
2. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China

收稿日期:2022-12-21 出版日期:2023-02-01 发布日期:2023-02-02
通讯作者: MA Chao, LIU Kai E-mail:chaoma_chem@tsinghua.edu.cn;kailiu@tsinghua.edu.cn
基金资助:
This work was supported by the National Key R&D Program of China (No.2021YFB3502300), the National Natural Science Foundation of China (Nos.22125701, 22020102003, 22277064), the Beijing Nova Program, China (No.Z211100002121132) and the Beijing Natural Science Foundation, China (No.2222010).

Engineering Mechanical Strong Biomaterials Inspired by Structural Building Blocks in Nature

LI Jiahe¹, MA Chao¹, ZHANG Hongjie^1,2, LIU Kai¹

1. Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China;
2. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China

Received:2022-12-21 Online:2023-02-01 Published:2023-02-02
Contact: MA Chao, LIU Kai E-mail:chaoma_chem@tsinghua.edu.cn;kailiu@tsinghua.edu.cn
Supported by:
This work was supported by the National Key R&D Program of China (No.2021YFB3502300), the National Natural Science Foundation of China (Nos.22125701, 22020102003, 22277064), the Beijing Nova Program, China (No.Z211100002121132) and the Beijing Natural Science Foundation, China (No.2222010).

摘要/Abstract

摘要： The intricate multiscale architectures in natural structural building blocks provide many sources of inspiration for the designs of artificial biomaterials. In nature, the assembly of highly ordered molecular crystals and amorphous aggregates often derives from inter- and intra-molecular interactions of biomacromolecules, e.g., proteinaceous materials. The structural biomaterials derived from the protein self-assembly behave with remarkable mechanical performance. However, there is still a grand challenge to mimic the mechanical properties of natural protein-based biomaterials in a rational design fashion to yield comparable man-made synthetic ensembles. In this review, a brief perspective on current challenges and advances in terms of bioinspired structural materials is presented. We outline a framework for mimicking protein self-assembly of natural building blocks across multiscale and highlight the critical role of synthetic biology and chemical modifications in material biosynthesis. Particularly, we focus on the design and promising applications of protein-based fibers, adhesives, dynamic hydrogels and engineered living materials, in which natural mechanical functions are effectively reproduced.

关键词: Bioinspired material, Protein self-assembly, Mechanical property, Synthetic biology, Molecular engineering

Abstract: The intricate multiscale architectures in natural structural building blocks provide many sources of inspiration for the designs of artificial biomaterials. In nature, the assembly of highly ordered molecular crystals and amorphous aggregates often derives from inter- and intra-molecular interactions of biomacromolecules, e.g., proteinaceous materials. The structural biomaterials derived from the protein self-assembly behave with remarkable mechanical performance. However, there is still a grand challenge to mimic the mechanical properties of natural protein-based biomaterials in a rational design fashion to yield comparable man-made synthetic ensembles. In this review, a brief perspective on current challenges and advances in terms of bioinspired structural materials is presented. We outline a framework for mimicking protein self-assembly of natural building blocks across multiscale and highlight the critical role of synthetic biology and chemical modifications in material biosynthesis. Particularly, we focus on the design and promising applications of protein-based fibers, adhesives, dynamic hydrogels and engineered living materials, in which natural mechanical functions are effectively reproduced.

Key words: Bioinspired material, Protein self-assembly, Mechanical property, Synthetic biology, Molecular engineering

LI Jiahe, MA Chao, ZHANG Hongjie, LIU Kai. Engineering Mechanical Strong Biomaterials Inspired by Structural Building Blocks in Nature[J]. 高等学校化学研究, 2023, 39(1): 92-106.

LI Jiahe, MA Chao, ZHANG Hongjie, LIU Kai. Engineering Mechanical Strong Biomaterials Inspired by Structural Building Blocks in Nature[J]. Chemical Research in Chinese Universities, 2023, 39(1): 92-106.

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Engineering Mechanical Strong Biomaterials Inspired by Structural Building Blocks in Nature

Engineering Mechanical Strong Biomaterials Inspired by Structural Building Blocks in Nature

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