Framework Nucleic Acids for Cell Imaging and Therapy

doi:10.1007/s40242-019-9249-4

摘要/Abstract

摘要： Over the past decade, structural DNA nanotechnology has been well developed to be a promising and powerful technique to generate various nanostructures with programmability, spatial organization and biocompatibi-lity. With the advent of computer-aided tools, framework nucleic acids have been employed in a series of biomedical applications, ranging from biosensing, bioimaging, diagnosis, to therapeutics. In this review, we summarized recent advances in the construction of precisely assembled DNA nanostructures, and DNA-engineered biomimetics. We also outlined the challenges and opportunities for the translational applications of framework nucleic acids.

关键词: DNA nanotechnology, Framework nucleic acid, DNA origami, Therapy, Cellular imaging

Abstract: Over the past decade, structural DNA nanotechnology has been well developed to be a promising and powerful technique to generate various nanostructures with programmability, spatial organization and biocompatibi-lity. With the advent of computer-aided tools, framework nucleic acids have been employed in a series of biomedical applications, ranging from biosensing, bioimaging, diagnosis, to therapeutics. In this review, we summarized recent advances in the construction of precisely assembled DNA nanostructures, and DNA-engineered biomimetics. We also outlined the challenges and opportunities for the translational applications of framework nucleic acids.

Key words: DNA nanotechnology, Framework nucleic acid, DNA origami, Therapy, Cellular imaging

GE Zhilei, LI Qian, FAN Chunhai. Framework Nucleic Acids for Cell Imaging and Therapy[J]. 高等学校化学研究, 2020, 36(1): 1-9.

GE Zhilei, LI Qian, FAN Chunhai. Framework Nucleic Acids for Cell Imaging and Therapy[J]. Chemical Research in Chinese Universities, 2020, 36(1): 1-9.

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