Bioapplications Manipulated by AIEgens with Nonlinear Optical Effect

doi:10.1007/s40242-021-0395-0

高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (1): 25-37.doi: 10.1007/s40242-021-0395-0

Bioapplications Manipulated by AIEgens with Nonlinear Optical Effect

HAO Yuxuan¹, XU Shengpeng¹, CHEN Ming¹, QIAN Jun³, TANG Ben Zhong²

1. College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, P. R. China;
2. Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, P. R. China;
3. College of Optical Science and Engineering, Zhejiang University, Hangzhou 310058, P. R. China

收稿日期:2020-11-28 修回日期:2020-12-16 出版日期:2021-02-01 发布日期:2021-02-03
通讯作者: CHEN Ming, TANG Ben Zhong, QIAN Jun E-mail:chenming@jnu.edu.cn;tangbenz@ust.hk;qianjun@zju.edu.cn
基金资助:
This work is supported by the National Natural Science Foundation of China(Nos.21905113, 21788102), the Natural Science Foundation of Guangdong Province, China(No.2020A1515010622), the Project of the Innovation and Technology Commission of Hong Kong, China(No.ITC-CNERC14S01) and the Fundamental Research Funds for the Central Universities of China(No.21619316).

Bioapplications Manipulated by AIEgens with Nonlinear Optical Effect

HAO Yuxuan¹, XU Shengpeng¹, CHEN Ming¹, QIAN Jun³, TANG Ben Zhong²

1. College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, P. R. China;
2. Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, P. R. China;
3. College of Optical Science and Engineering, Zhejiang University, Hangzhou 310058, P. R. China

Received:2020-11-28 Revised:2020-12-16 Online:2021-02-01 Published:2021-02-03
Contact: CHEN Ming, TANG Ben Zhong, QIAN Jun E-mail:chenming@jnu.edu.cn;tangbenz@ust.hk;qianjun@zju.edu.cn
Supported by:
This work is supported by the National Natural Science Foundation of China(Nos.21905113, 21788102), the Natural Science Foundation of Guangdong Province, China(No.2020A1515010622), the Project of the Innovation and Technology Commission of Hong Kong, China(No.ITC-CNERC14S01) and the Fundamental Research Funds for the Central Universities of China(No.21619316).

摘要/Abstract

摘要： The modern medicine requires precise diagnostic techniques while the fluorescent imaging shows great potential in such applications due to its excellent sensitivity and high resolution. However, conducting fluorescent imaging in deep-tissue is not so easy because most luminogens show short-wavelength excitation, which may undergo severe light scattering by the bio-tissue. The marriage of fluorescent imaging with nonlinear optical(NLO) effect can alleviate such adverse effects by utilizing NIR laser to reduce light scattering. On the other hand, scientists are enthusiastic in pursuing luminescent materials, which can match well with NLO application. Aggregation-induced emission(AIE) materials exhibit huge advantages in such aspect not only because of its high luminescent efficiency in aggregate state but also due to its excellent photostability(a key factor to meet laser application because of its ultrahigh energy density). Inspired by this, many interesting and meaningful works have sprung up based on AIE luminogens with NLO effect in recent years, and for such reason, it motivates us to summarize them to give a systematic presentation. Here, we first give a brief introduction of the principle of NLO effect. Secondly, the strategies for improving the NLO effect of AIE materials, such as increasing molecular conjugation, introduction of donor-acceptor effect, induction of centrally asymmetric array of AIE molecules in crystals and introduction of intermolecular interactions are clarified. In the final part, we also present the multiple applications of AIEgens with NLO effect in cell imaging, deep-tissue tumor and brain blood vessel imaging and photodynamic therapy. We believe, with this review, the topic will attract more attention from the scientists in multi-science field to accelerate the development of AIE materials in biomedical applications.

关键词: Aggregation-induced emission, Nonlinear optical effect, Bioimaging, Photodynamic therapy

Abstract: The modern medicine requires precise diagnostic techniques while the fluorescent imaging shows great potential in such applications due to its excellent sensitivity and high resolution. However, conducting fluorescent imaging in deep-tissue is not so easy because most luminogens show short-wavelength excitation, which may undergo severe light scattering by the bio-tissue. The marriage of fluorescent imaging with nonlinear optical(NLO) effect can alleviate such adverse effects by utilizing NIR laser to reduce light scattering. On the other hand, scientists are enthusiastic in pursuing luminescent materials, which can match well with NLO application. Aggregation-induced emission(AIE) materials exhibit huge advantages in such aspect not only because of its high luminescent efficiency in aggregate state but also due to its excellent photostability(a key factor to meet laser application because of its ultrahigh energy density). Inspired by this, many interesting and meaningful works have sprung up based on AIE luminogens with NLO effect in recent years, and for such reason, it motivates us to summarize them to give a systematic presentation. Here, we first give a brief introduction of the principle of NLO effect. Secondly, the strategies for improving the NLO effect of AIE materials, such as increasing molecular conjugation, introduction of donor-acceptor effect, induction of centrally asymmetric array of AIE molecules in crystals and introduction of intermolecular interactions are clarified. In the final part, we also present the multiple applications of AIEgens with NLO effect in cell imaging, deep-tissue tumor and brain blood vessel imaging and photodynamic therapy. We believe, with this review, the topic will attract more attention from the scientists in multi-science field to accelerate the development of AIE materials in biomedical applications.

Key words: Aggregation-induced emission, Nonlinear optical effect, Bioimaging, Photodynamic therapy

HAO Yuxuan, XU Shengpeng, CHEN Ming, QIAN Jun, TANG Ben Zhong. Bioapplications Manipulated by AIEgens with Nonlinear Optical Effect[J]. 高等学校化学研究, 2021, 37(1): 25-37.

HAO Yuxuan, XU Shengpeng, CHEN Ming, QIAN Jun, TANG Ben Zhong. Bioapplications Manipulated by AIEgens with Nonlinear Optical Effect[J]. Chemical Research in Chinese Universities, 2021, 37(1): 25-37.

参考文献

[1] Harris S. E., Hau L. V., Phy. Rev. Lett., 1999, 82, 4611
[2] Nalwa H. S., Adv. Mater., 1993, 5, 341
[3] Elsa G., Opt. Express., 2013, 21, 30532
[4] Gu B., Zhao C., Baev A., Yong K.-T., Wen S., Prasad P. N., Adv. Opt. Photon., 2016, 8, 328
[5] Panwar N., Soehartono A. M., Chan K. K., Zeng S., Xu G., Qu J., Coquet P., Yong K.-T., Chen, X., Chem. Rev., 2019, 119, 9559
[6] Kobayashi H., Ogawa M., Alford R., Choyke P. L., Urano Y., Chem. Rev., 2010, 110, 2620
[7] Gao P., Pan W., Li N., Tang B., Chem. Sci., 2019, 10, 6035
[8] Peng H.-S., Chiu D. T., Chem. Soc. Rev., 2015, 44, 4699
[9] Wolfbeis O. S, Chem. Soc. Rev., 2015, 44, 4743
[10] Koide Y., Urano Y., Hanaoka K., Piao W., Kusakabe M., Saito N., Terai T., Okabe T., Nagano T., J. Am. Chem. Soc., 2012, 134, 5029
[11] Yuan L., Lin W., Zhao S., Gao W., Chen B., He L., Zhu S., J. Am. Chem. Soc., 2012, 134, 13510
[12] Kolavekar S. B., Ayachit N. H., Jagannath G., NagaKrishnakanth K., Venugopal Rao S., Opt. Mater., 2018, 83, 34
[13] Evans O. R., Lin W., Acc. Chem. Res., 2002, 35, 511
[14] Chung I., Kanatzidis M. G., Chem. Mater., 2014, 26, 849
[15] Scarpa G., Idzko A.-L., Götz S., Thalhammer S., Macromol. Biosci., 2010, 10, 378
[16] Feron K., Lim R., Sherwood C., Keynes A., Brichta A., Dastoor P. C., Int. J. Mol. Sci., 2018, 19, 2382
[17] Yuan W. Z., Lu P., Chen S., Lam J. W. Y., Wang Z., Liu Y., Kwok H. S., Ma Y., Tang B. Z., Adv. Mater. 2010, 22, 2159
[18] Nie H., Hu K., Cai Y., Peng Q., Zhao Z., Hu R., Chen J., Su S.-J., Qin A., Tang B. Z., Mater. Chem. Front., 2017, 1, 1125
[19] He T., Niu N., Chen Z., Li S., Liu S., Li J., Adv. Funct. Mater., 2018, 28, 1706196
[20] Zhang J., Zheng M., Zhang F., Xu B., Tian W., Xie Z., Chem. Mater., 2016, 28, 8825
[21] Feng S., Liu D., Feng W., Feng G., Anal. Chem., 2017, 89, 3754
[22] Zhao Y., Zheng Q., Dakin K., Xu K., Martinez M. L., Li W.-H., J. Am. Chem. Soc., 2004, 126, 4653
[23] Wang L., Du W., Hu Z., Uvdal K., Li L., Huang W., Angew. Chem. Int. Ed., 2019, 58, 14026
[24] Mei J., Leung N. L. C., Kwok R. T. K., Lam J. W. Y., Tang B. Z., Chem. Rev., 2015, 115, 11718
[25] Chen M., Zhang X., Liu J., Liu F., Zhang R., Wei P., Feng H., Tu M., Qin A., Lam J. W. Y., Ding D., Tang B. Z., ACS Nano, 2020, 14, 4265
[26] Chen M., Hu X., Liu J., Li B., Leung, Nelson L. C., Viglianti L., Cheung T. S., Sung H. H. Y., Kwok R. T. K., Williams I. D., Qin A., Lam J. W. Y., Tang B. Z., Chem. Sci., 2018, 9, 7829
[27] Ding D., Li K., Liu B., Tang B. Z., Acc. Chem. Res., 2013, 46, 2441
[28] Chen C., Ou H., Liu R., Ding D., Adv. Mater., 2020, 32, 1806331
[29] Zhuang W., Ma B., Hu J., Jiang J., Li G., Yang L., Wang Y., Theranostics, 2019, 9, 6618
[30] Lou X., Zhao Z., Tang B. Z., Small, 2016, 12, 6430
[31] Hulme K. F., Rep. Prog. Phys., 1973, 36, 497
[32] Ward J. F., Miller C. K., Phys. Rev. A, 1979, 19, 826
[33] Qian J., Zhu Z., Qin A., Qin W., Chu L., Cai F., Zhang H., Wu Q., Hu R., Tang B. Z., He S., Adv. Mater., 2015, 27, 2332
[34] Hu R., Maldonado J. L., Rodriguez M., Deng C., Jim C. K. W., Lam J. W. Y., Yuen M. M. F., Ramos-Ortiz G., Tang B. Z., J. Mater. Chem., 2012, 22, 232
[35] Yang Q., Hu Z., Zhu S., Ma R., Ma H., Ma Z., Wan H., Zhu T., Jiang Z., Liu W., Jiao L., Sun H., Liang Y., Dai H., J. Am. Chem. Soc., 2018, 140, 1715
[36] Uoyama H., Goushi K., Shizu K., Nomura H., Adachi C., Nature, 2012, 492, 234
[37] Shuai Z., Ramasesha S., Brédas J. L., Chem. Phys. Lett., 1996, 250, 14
[38] Gao Y., Feng G., Jiang T., Goh C., Ng L., Liu B., Li B., Yang L., Hua J., Tian H., Adv. Funct. Mater., 2015, 25, 2857
[39] Yang J., Gao Y., Jiang T., Liu W., Liu C., Lu N., Li B., Mei J., Peng Q., Hua J., Mater. Chem. Front., 2017, 1, 1396
[40] Zhang Y., Li J., Tang B. Z., Wong K. S., J. Phys. Chem. C, 2014, 118, 26981
[41] Qin W., Ding D., Liu J., Yuan W. Z., Hu Y., Liu B., Tang B. Z., Adv. Funct. Mater., 2012, 22, 771
[42] Chen M., Liu J., Liu F., Nie H., Zeng J., Lin G., Qin A., Tu M., He Z., Sung H. H. Y., Williams I. D., Lam J. W. Y., Tang B. Z., Adv. Funct. Mater., 2019, 29, 1903834
[43] Chen M., Qin A., Lam J. W. Y., Tang B. Z., Coord. Chem. Rev., 2020, 422, 213472
[44] Dong Y., Lam J. W. Y., Qin A., Li Z., Sun J., Sung H. H. Y., Williams I. D., Tang B. Z., Chem. Commun., 2007, 1, 40
[45] Galer P., Korošec R. C., Vidmar M., Šket B., J. Am.Chem. Soc., 2014, 136, 7383
[46] Duan Y., Ju C., Yang G., Fron E., Coutino-Gonzalez E., Semin S., Fan C., Balok R.S., Cremers J., Tinnemans P., Feng Y., Li Y., Hofkens J., Rowan A. E., Rasing T., Xu J., Adv. Funct. Mater., 2016, 26, 8968
[47] Xiong J., Li X., Yuan C., Semin S., Yao Z., Xu J., Rasing T., Bu X.-H., Mater. Chem. Front., 2018, 2, 2263
[48] Zheng Z., Li D., Liu Z., Peng H.-Q., Sung H. H. Y., Kwok R. T. K., Williams I. D., Lam J. W. Y., Qian J., Tang B. Z., Adv. Mater., 2019, 31, 1904799
[49] Liu H.-W., Chen L., Xu C., Li Z., Zhang H., Zhang X.-B., Tan W., Chem. Soc. Rev., 2018, 47, 7140
[50] Wang L., Zhang J., An X., Duan H., Org. Biomol. Chem., 2020, 18, 1522
[51] Chen Y., Zhu C., Yang Z., Chen J., He Y., Jiao Y., He W., Qiu L., Cen J., Guo Z. J., Angew. Chem. Int. Ed., 2013, 125, 1732
[52] Chen M., Chen R., Shi Y., Wang J., Cheng Y., Li Y., Gao X., Yan Y., Sun J. Z., Qin A., Kwok R. T. K., Lam J. W. Y., Tang B. Z., Adv. Funct. Mater., 2018, 28, 1704689
[53] Chen L., Wu D., Lim C. S., Kim D., Nam S.-J., Lee W., Kim G., Kim H. M., Yoon J., Chem. Commun., 2017, 53, 4791
[54] Gu J., Li X., Zhou Z., Liao R., Gao J., Tang Y., Wang Q., Chem. Eng. J., 2019, 368, 157
[55] Huang Y., Zhang P., Gao M., Zeng F., Qin A., Wu S., Tang B. Z., Chem. Commun., 2016, 52, 7288
[56] Zhang Q., Zhang P., Gong Y., Ding C., Sens. Actuators B., 2019, 278, 73
[57] Wang J., Chen Q., Tian N., Zhu W., Zou H., Wang X., Li X., Fan X., Jiang G., Tang B. Z., J. Mater. Chem. B, 2018, 6, 1595
[58] Wu Y., Huang S., Zeng F., Wang J., Yu C., Huang J., Xie H., Wu S., Chem. Commun., 2015, 51, 12791
[59] Dickinson B. C., Chang C. J., J. Am. Chem. Soc., 2008, 130, 9638
[60] Lim C. S., Masanta G., Kim H. J., Han J. H., Kim H. M., Cho B. R., J. Am. Chem. Soc., 2011, 133, 11132
[61] Zhang R., Niu G., Li X., Guo L., Zhang H., Yang R., Chen Y., Yu X., Tang B. Z., Chem. Sci., 2019, 10, 1994
[62] Zhang R. Y., Niu G. L., Lu Q., Huang X. L., Chau J. H. C., Kwok R. T. K., Yu X. Q., Li M. H., Lam J. W. Y., Tang B. Z., Chem. Sci., 2020, 11, 7676
[63] Jiang M., Gu X., Kwok R. T. K., Li Y., Sung H. H. Y., Zheng X., Zhang Y., Lam J. W. Y., Williams I. D., Huang X., Wong K. S., Tang B. Z., Adv. Funct. Mater., 2018, 28, 1704589
[64] Fam T. K., Klymchenko A. S., Collot M., Materials, 2018, 11, 1768
[65] Shi J., Tian Y., Guo B., Wu Y., Jing J., Zhang R., Zhang X., Sens. Actuators B, 2019, 284, 545
[66] Jiang M., Gu X., Lam J. W. Y., Zhang Y., Kwok R. T. K., Wong K. S., Tang B. Z., Chem. Sci., 2017, 8, 5440
[67] Niu G., Zhang R., Kwong J. P. C., Lam J. W. Y., Chen C., Wang J., Chen Y., Feng X., Kwok R. T. K., Sung H. H. Y., Williams I. D., Elsegood M. R. J., Qu J., Ma C., Wong K. S., Yu X., Tang B. Z., Chem. Mater., 2018, 30, 4778
[68] Mehlem A., Hagberg C. E., Muhl L., Eriksson U., Falkevall A., Nat. Protoc., 2013, 8, 1149
[69] Situ B., Gao M., He X., Li S., He B., Guo F., Kang C., Liu S., Yang L., Jiang M., Hu Y., Tang B. Z., Zheng L., Mater. Horiz., 2019, 6, 546
[70] Wiktor J., Reshetnyak I., Strach M., Scarongella M., Buonsanti R., Pasquarello A., J. Phys. Chem. Lett., 2018, 9, 5698
[71] Wu L., Qu X., Chem. Soc. Rev., 2015, 44, 2963
[72] Bai H., Peng R., Wang D., Sawyer M., Fu T., Cui C., Tan W., Nanoscale, 2020, 12, 21571
[73] Niu G., Zheng X., Zhao Z., Zhang H., Wang J., He X., Chen Y., Shi X., Ma C., Kwok R. T. K., Lam J. W. Y., Sung H. H. Y., Williams I. D., Wong K. S., Wang P., Tang B. Z., J. Am. Chem. Soc., 2019, 141, 15111
[74] Wang S., Liu J., Goh C. C., Ng L. G., Liu B., Adv. Mater., 2019, 31, 1904447
[75] Crassard I., Bousser M. G., J. Neuroophthalmol., 2004, 24,156
[76] Dmytriw A. A., Song J. S. A., Yu E., Poon C. S., Neuroradiology, 2018, 60, 669
[77] Bousser M. G., J. Neurol., 2000, 247, 252
[78] Qi J., Sun C., Li D., Zhang H., Yu W., Zebibula A., Lam J. W. Y., Xi W., Zhu L., Cai F., Wei P., Zhu C., Kwok R. T. K., Streich L. L., Prevedel R., Qian J., Tang B. Z., ACS Nano, 2018, 12, 7936
[79] Qin W., Alifu N., Lam J. W. Y., Cui Y., Su H., Liang G., Qian J., Tang B. Z., Adv. Mater., 2020, 32, 2000364
[80] Ni H., Xu Z., Li D., Chen M., Tang B. Z., Qian J., J. Innov. Opt. Health Sci., 2019, 12, 1940005
[81] Gao H., Kam C., Chou T. Y., Wu M.-Y., Zhao X., Chen S., Nanoscale Horiz., 2020, 5, 488
[82] Chen S., Hong Y., Zeng Y., Sun Q., Liu Y., Zhao E., Bai G., Qu J., Hao J., Tang B. Z., Chem. Eur. J., 2015, 21, 4315
[83] Sternberg E. D., Dolphin D., Brückner C., Tetrahedron, 1998, 54, 4151
[84] Tavakkoli Yaraki M., Pan Y., Hu F., Yu Y., Liu B., Tan Y. N., Mater. Chem. Front., 2020, 4, 3074
[85] Calzavara-Pinton P. G., Venturini M., Sala R., J. Photochem. Photobiol., B:Biol, 2005, 78, 1
[86] Kou J., Dou D., Yang L., Oncotarget, 2017, 8, 81591
[87] Chen M., Xie W., Li D., Zebibula A., Wang Y., Qian J., Qin A., Tang B. Z., Chem. Eur. J., 2018, 24, 16603
[88] Alifu, N., Dong, X., Li, D., Sun, X., Zebibula, A., Zhang D., Zhang G., Qian J., Mater. Chem. Front., 2017, 1, 1746
[89] Gu B., Wu W., Xu G., Feng G., Yin F., Chong P. H. J., Qu J., Yong K.-T., Liu B., Adv. Mater., 2017, 29, 1701076
[90] Wang S., Chen H., Liu J., Chen C., Liu B., Adv. Funct. Mater., 2020, 30, 2002546
[91] Nixon R. A., Na. Med., 2013, 19, 983
[92] Sun C.-L., Li J., Wang X.-Z., Shen R., Liu S., Jiang J.-Q., Li T., Song Q.-W., Liao Q., Fu H.-B., Yao J.-N., Zhang H.-L., Chem, 2019, 5, 600

Bioapplications Manipulated by AIEgens with Nonlinear Optical Effect

Bioapplications Manipulated by AIEgens with Nonlinear Optical Effect

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