A Perspective: Electrospun Fibers for Repairing Spinal Cord Injury

doi:10.1007/s40242-021-1162-y

高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (3): 404-410.doi: 10.1007/s40242-021-1162-y

A Perspective: Electrospun Fibers for Repairing Spinal Cord Injury

ZHANG Xindan^1,2, GONG Bowen^1,2, ZHAI Jiliang³, ZHAO Yu³, LU Yonglai^1,2, ZHANG Liqun^1,2, XUE Jiajia^1,2

1. Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China;
2. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China;
3. Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, P. R. China

收稿日期:2021-04-09 修回日期:2021-05-08 出版日期:2021-06-01 发布日期:2021-05-08
通讯作者: XUE jiajia E-mail:jiajiaxue@mail.buct.edu.cn
基金资助:
This work was supported by the Key Program of Beijing Natural Science Foundation, China(No.Z200025), the National Natural Science Foundation of China (Nos.52073014, 82002049) and the Start-up Funding of the Beijing University of Chemical Technology, China.

A Perspective: Electrospun Fibers for Repairing Spinal Cord Injury

ZHANG Xindan^1,2, GONG Bowen^1,2, ZHAI Jiliang³, ZHAO Yu³, LU Yonglai^1,2, ZHANG Liqun^1,2, XUE Jiajia^1,2

1. Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China;
2. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China;
3. Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, P. R. China

Received:2021-04-09 Revised:2021-05-08 Online:2021-06-01 Published:2021-05-08
Contact: XUE jiajia E-mail:jiajiaxue@mail.buct.edu.cn
Supported by:
This work was supported by the Key Program of Beijing Natural Science Foundation, China(No.Z200025), the National Natural Science Foundation of China (Nos.52073014, 82002049) and the Start-up Funding of the Beijing University of Chemical Technology, China.

摘要/Abstract

摘要： Patients with spinal cord injury(SCI) are suffering disability and accompanying complications. Due to the complex biological processes and inhibitory microenvironment after SCI, advances in clinical treatment show obvious limitations for achieving a successful repair. Herein, we summarize recent advances in engineering strategies of using electrospun nanofibers to promote the neural regeneration and functional recovery after SCI. We firstly introduce the pathological mechanism of SCI and thus point out the challenges on the regeneration of the nerve. We then discuss the regenerative approaches by combining electrospun nanofibrous scaffolds with physical cues, biochemical cues(e.g., cells, growth factors and other biomolecules), external stimuli, and supporting materials filling in the inner lumen of the scaffolds. All these strategies have indicated their potentials to enhance the efficacy of repairing the SCI. At last, we provide a perspective on the future direction for designing the electrospun nanofibrous scaffolds in combination with imaging systems to realize the in-situ monitoring of regeneration progress for further improving the treatment outcome.

关键词: Spinal cord injury, Electrospun fiber, Growth factor, Cell therapy, External stimuli

Abstract: Patients with spinal cord injury(SCI) are suffering disability and accompanying complications. Due to the complex biological processes and inhibitory microenvironment after SCI, advances in clinical treatment show obvious limitations for achieving a successful repair. Herein, we summarize recent advances in engineering strategies of using electrospun nanofibers to promote the neural regeneration and functional recovery after SCI. We firstly introduce the pathological mechanism of SCI and thus point out the challenges on the regeneration of the nerve. We then discuss the regenerative approaches by combining electrospun nanofibrous scaffolds with physical cues, biochemical cues(e.g., cells, growth factors and other biomolecules), external stimuli, and supporting materials filling in the inner lumen of the scaffolds. All these strategies have indicated their potentials to enhance the efficacy of repairing the SCI. At last, we provide a perspective on the future direction for designing the electrospun nanofibrous scaffolds in combination with imaging systems to realize the in-situ monitoring of regeneration progress for further improving the treatment outcome.

Key words: Spinal cord injury, Electrospun fiber, Growth factor, Cell therapy, External stimuli

ZHANG Xindan, GONG Bowen, ZHAI Jiliang, ZHAO Yu, LU Yonglai, ZHANG Liqun, XUE Jiajia. A Perspective: Electrospun Fibers for Repairing Spinal Cord Injury[J]. 高等学校化学研究, 2021, 37(3): 404-410.

ZHANG Xindan, GONG Bowen, ZHAI Jiliang, ZHAO Yu, LU Yonglai, ZHANG Liqun, XUE Jiajia. A Perspective: Electrospun Fibers for Repairing Spinal Cord Injury[J]. Chemical Research in Chinese Universities, 2021, 37(3): 404-410.

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A Perspective: Electrospun Fibers for Repairing Spinal Cord Injury

A Perspective: Electrospun Fibers for Repairing Spinal Cord Injury

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