One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T 1-Weighted Magnetic Resonance Imaging In vivo

doi:10.1007/s40242-019-8327-y

高等学校化学研究 ›› 2019, Vol. 35 ›› Issue (3): 537-541.doi: 10.1007/s40242-019-8327-y

One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T ₁-Weighted Magnetic Resonance Imaging In vivo

HUANG Sa, HAN Qinghe, WANG Lei, GONG Tingting, YUAN Qinghai

Department of Radiology, the Second Hospital of Jilin University, Changchun 130041, P. R. China

收稿日期:2018-10-12 修回日期:2019-01-19 出版日期:2019-06-01 发布日期:2019-03-27
通讯作者: YUAN Qinghai E-mail:yuanqinghai123@sina.com
基金资助:
Supported by the Scientific Research Fund of Jilin Provincial Education Department, China(No.JJKH20170858KJ), the Spe-cial Fund for Health of Jilin Provincial Department of Finance, China(No.20171559863) and the State Scholarship Fund by the China Scholarship Council(No.201706175109).

One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T ₁-Weighted Magnetic Resonance Imaging In vivo

HUANG Sa, HAN Qinghe, WANG Lei, GONG Tingting, YUAN Qinghai

Department of Radiology, the Second Hospital of Jilin University, Changchun 130041, P. R. China

Received:2018-10-12 Revised:2019-01-19 Online:2019-06-01 Published:2019-03-27
Contact: YUAN Qinghai E-mail:yuanqinghai123@sina.com
Supported by:
Supported by the Scientific Research Fund of Jilin Provincial Education Department, China(No.JJKH20170858KJ), the Spe-cial Fund for Health of Jilin Provincial Department of Finance, China(No.20171559863) and the State Scholarship Fund by the China Scholarship Council(No.201706175109).

摘要/Abstract

摘要： Polyethylene glycol modified(PEGylated) NaGdF₄(PEG-NaGdF₄) nanoparticles as a novel T₁-weighted magnetic resonance imaging(MRI) contrast agent was successfully constructed by a one-pot hydrothermal synthesis method. Because of the functionalization of PEG, the nanoprobes had excellent dispersity, excellent stability and high biocompatibility. More importantly, the as-prepared PEG-NaGdF₄ nanoprobes revealed the high longitudinal relaxivity value and prominent T₁-weighted MRI contrast performance, which was superior to the commercial MRI contrast agents. With the facile synthesis, excellent dispersity, outstanding stability, remarkable contrast performance and high biocompatibility, the PEGylated NaGdF₄ nanoparticles brought more opportunities to the new generation of nanoparticulate-based T₁-weighted MRI contrast agents in clinic.

关键词: Nanoparticulate contrast agent, Polyethylene glycol, T₁-Weighted magnetic resonance imaging, Biocompatibility

Abstract: Polyethylene glycol modified(PEGylated) NaGdF₄(PEG-NaGdF₄) nanoparticles as a novel T₁-weighted magnetic resonance imaging(MRI) contrast agent was successfully constructed by a one-pot hydrothermal synthesis method. Because of the functionalization of PEG, the nanoprobes had excellent dispersity, excellent stability and high biocompatibility. More importantly, the as-prepared PEG-NaGdF₄ nanoprobes revealed the high longitudinal relaxivity value and prominent T₁-weighted MRI contrast performance, which was superior to the commercial MRI contrast agents. With the facile synthesis, excellent dispersity, outstanding stability, remarkable contrast performance and high biocompatibility, the PEGylated NaGdF₄ nanoparticles brought more opportunities to the new generation of nanoparticulate-based T₁-weighted MRI contrast agents in clinic.

Key words: Nanoparticulate contrast agent, Polyethylene glycol, T₁-Weighted magnetic resonance imaging, Biocompatibility

HUANG Sa, HAN Qinghe, WANG Lei, GONG Tingting, YUAN Qinghai. One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T ₁-Weighted Magnetic Resonance Imaging In vivo[J]. 高等学校化学研究, 2019, 35(3): 537-541.

参考文献 34

[1]	Louie A. Y., Chem. Rev., 2010, 110(5), 3146
[2]	Na H. B., Song I. C., Hyeon T., Adv. Mater., 2009, 21(21), 2133
[3]	Ni D. L., Bu W. B., Ehlerding E. B., Cai W. B., Shi J. L., Chem. Soc. Rev., 2017, 46(23), 7438
[4]	Caravan P., Ellison J. J., McMurry T. J., Lauffer R. B., Chem. Rev., 1999, 99(9), 2293
[5]	Viswanathan S., Kovacs Z., Green K. N., Ratnakar S. J., Sherry A. D., Chem. Rev., 2010, 110(5), 2960
[6]	Morrow J. R., Toth E., Inorg. Chem., 2017, 56(11), 10832
[7]	Penfield J. G., Reilly R. F., Nat. Clin. Pract. Nephr., 2007, 3(12), 654
[8]	Canavese C., Mereu M. C., Aime S., Lazzarich E., Fenoglio R., Quaglia M., Stratta P., J. Nephrol., 2008, 21(3), 324
[9]	Peak A. S., Sheller A., Ann. Pharmacother., 2007, 41(9), 1481
[10]	Sun C., Lee J. S. H., Zhang M. Q., Adv. Drug Deliver. Rev., 2008, 60(11), 1252
[11]	Liong M., Lu J., Kovochich M., Xia T., Ruehm S. G., Nel A. E., Tamanoi F., Zink J. I., ACS Nano, 2008, 2(5), 889
[12]	Zhou J., Liu Z., Li F. Y., Chem. Soc. Rev., 2012, 41(3), 1323
[13]	Cheng L., Wang C., Liu Z., Nanoscale, 2013, 5(1), 23
[14]	Xie J., Liu G., Eden H. S., Ai H., Chen X. Y., Acc. Chem. Res., 2011, 44(10), 883
[15]	Wang F., Banerjee D., Liu Y. S., Chen X. Y., Liu X. G., Analyst, 2010, 135(8), 1839
[16]	Caravan P., Acc. Chem. Res., 2009, 42(7) 851
[17]	Dong K., Liu Z., Liu J. H., Huang S., Li Z. H., Yuan Q. H., Ren J. S., Qu X. G., Nanoscale, 2014, 6(4), 2211
[18]	Huang C. X., Chen H. J., Li F., Wang W. N., Li D. D., Yang X. Z., Miao Z. H., Zha Z. B., Lu Y., Qian H. S., J. Mater. Chem. B, 2017, 5(48), 9487
[19]	Liu K., Yan X., Xu Y. J., Dong L., Hao L. N., Song Y. H., Li F., Su Y., Wu Y. D., Qian H. S., Tao W., Yang X. Z., Zhou W., Lu Y., Biomater. Sci.-UK, 2017, 5(12), 2403
[20]	Wang W. N., Huang C. X., Zhang C. Y., Zhao M. L., Zhang J., Chen H. J., Zha Z. B., Zhao T. T., Qian H. S., Appl. Catal. B:Environ., 2018, 224, 854
[21]	Wen H. Q., Peng H. Y., Liu K., Bian M. H., Xu Y. J., Dong L., Yan X., Xu W. P., Tao W., Shen J. L., Lu Y., Qian H. S., ACS Appl. Mater. Inter., 2017, 9(11), 9226
[22]	Deng H. L., Huang S., Xu C., Talanta, 2018, 184, 461
[23]	Huang S., Liu J. H., Liu D., Yuan Q. H., New J. Chem., 2012, 36(6), 1335
[24]	Liu Y., Li D. Z., Zhang Y., Liu Z. H., Xie R. G., Chem. Res. Chinese Universities, 2015, 31(1), 1
[25]	Bridot J. L., Faure A. C., Laurent S., Riviere C., Billotey C., Hiba B., Janier M., Josserand V., Coll J. L., Vander Elst L., Muller R., Roux S., Perriat P., Tillement O., J. Am. Chem. Soc., 2007, 129(16), 5076
[26]	Dong K., Ju E. G., Liu J. H., Han X. L., Ren J. S., Qu X. G., Nanoscale, 2014, 6(20), 12042
[27]	Huang S., Chen P., Xu C., Talanta, 2017, 165, 161
[28]	Yang H. S., Santra S., Walter G. A., Holloway P. H., Adv. Mater., 2006, 18(21) 2890
[29]	Kojima C., Cho S. H., Higuchi E., Res. Chem. Intermediat., 2012, 38(6), 1279
[30]	Yallapu M. M., Foy S. P., Jain T. K., Labhasetwar V., Pharm. Res., 2010, 27(11), 2283
[31]	Passuello T., Pedroni M., Piccinelli F., Polizzi S., Marzola P., Tambalo S., Conti G., Benati D., Vetrone F., Bettinelli M., Speghini A., Nanoscale, 2012, 4(24), 7682
[32]	Torchilin V. P., Adv. Drug Deliver. Rev., 2002, 54(2), 235
[33]	Lu Y., Xu Y. J., Zhang G. B., Ling D. S., Wang M. Q., Zhou Y., Wu Y. D., Wu T., Hackett M. J., Kim B. H., Chang H., Kim J., Hu X. T., Dong L., Lee N., Li F. Y., He J. C., Zhang L., Wen H. Q., Yang B., Choi S. H., Hyeon T., Zou D. H., Nat. Biomed. Eng., 2017, 1(8), 637
[34]	Liu K., Dong L., Xu Y. J., Yan X., Li F., Lu Y., Tao W., Peng H. Y., Wu Y. D., Su Y., Ling D. S., He T., Qian H. S., Yu, S. H., Biomaterials, 2018, 158, 74

One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T ₁-Weighted Magnetic Resonance Imaging In vivo

One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T ₁-Weighted Magnetic Resonance Imaging In vivo

可视化

摘要/Abstract

引用本文

使用本文

参考文献 34

相关文章 10

编辑推荐

Metrics

本文评价

[1]	LUO Yu, GONG Xiaoyan Shawn, XU Zhiwei, MENG Kai, ZHANG Ke-Qin, ZHAO Huijing. PTFE Electrospun Stent Graft——Preparation, Properties and Its Industrialization Prospect[J]. 高等学校化学研究, 2021, 37(3): 589-597.
[2]	ZHAO Yanhui, YU Haifeng, LIAO Peiqiu, WANG Wenju. Green and Efficient Synthesis of 3-Pyrazolyl Indoles in Water[J]. 高等学校化学研究, 2020, 36(5): 847-852.
[3]	XIONG Jin'en, LI Shuang, LI Yi, CHEN Yingli, LIU Yu, GAN Junlan, JU Jiahui, XIAN Yaoling, XIONG Xiaohui. Fluorescent Aptamer-Polyethylene Glycol Functionalized Graphene Oxide Biosensor for Profenofos Detection in Food[J]. 高等学校化学研究, 2020, 36(5): 787-794.
[4]	LIU Guomin, LI Yalong, YANG Shuting, ZHAO Yi'an, LU Tiancheng, JIA Wenyuan, JI Xuan, LUO Yungang. DOPA-IGF-1 Coated HA/PLGA Microspheres Promoting Proliferation and Osteoclastic Differentiation of Rabbit Bone Mesenchymal Stem Cells[J]. 高等学校化学研究, 2019, 35(3): 514-520.
[5]	LU Xueting, FENG Wei, WANG Honglei, HU Qianqian, GUAN Shuang, GUO Peipei. Bentonite Reinforced Tough Composite Hydrogels as Potential Artificial Articular Cartilage[J]. 高等学校化学研究, 2018, 34(6): 1028-1034.
[6]	MA Yanhong, JIANG Yan, LIANG Yuan, ZHANG Weiwei, ZHANG Hongwen, ZHANG Rong. Preparation and Biocompatibility of Polyester Films Grafted with Functional mPEG Copolymers[J]. 高等学校化学研究, 2017, 33(5): 847-852.
[7]	JIANG Yuhang, LI Yao, WANG Xuesong, PIAO Linglan, SHI Zuosen, CUI Zhanchen. Fabrication of New Transparent and Hydrophilic Hybrid Anti-fog Coating from Silane Coupler Modified by Polyethylene Glycols[J]. 高等学校化学研究, 2017, 33(1): 150-154.
[8]	XIAO Yanlong, ZHAO Lei, SHI Yongfeng, LIU Ning, LIU Yongli, LIU Bin, XU Qinghua, HE Chaoliang, CHEN Xuesi. Surface Modification of 316L Stainless Steel by Grafting Methoxy Poly(ethylene glycol) to Improve the Biocompatibility[J]. 高等学校化学研究, 2015, 31(4): 651-657.
[9]	ZHANG Yinan, JIANG Dong, HE Zhi, YU Yunwu, ZHANG Haibo, JIANG Zhenhua. Hydrothermal Synthesis of PEG-capped ZnS：Mn²⁺ Quantum Dots Nanocomposites[J]. 高等学校化学研究, 2014, 30(1): 176-180.
[10]	JIN Gu*, YAO Qi-zhi, DONG Li-quan and MA Feng. PEG-grafted PVA Membrane and Its Blood Compatibility[J]. 高等学校化学研究, 2011, 27(6): 1078-1082.