Surface Modification of 316L Stainless Steel by Grafting Methoxy Poly(ethylene glycol) to Improve the Biocompatibility

doi:10.1007/s40242-015-5027-0

高等学校化学研究 ›› 2015, Vol. 31 ›› Issue (4): 651-657.doi: 10.1007/s40242-015-5027-0

Surface Modification of 316L Stainless Steel by Grafting Methoxy Poly(ethylene glycol) to Improve the Biocompatibility

XIAO Yanlong¹, ZHAO Lei¹, SHI Yongfeng¹, LIU Ning¹, LIU Yongli¹, LIU Bin¹, XU Qinghua², HE Chaoliang², CHEN Xuesi²

1. The Second Hospital of Jilin University, Changchun 130041, P. R. China;
2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

收稿日期:2015-01-20 修回日期:2015-04-08 出版日期:2015-08-01 发布日期:2015-04-13
通讯作者: LIU Bin E-mail:liubin3333@vip.sina.com
基金资助:
Supported by the Bethune Frontier Interdisciplinary Innovation Project of Jilin University, China(No.2013106020).

Surface Modification of 316L Stainless Steel by Grafting Methoxy Poly(ethylene glycol) to Improve the Biocompatibility

XIAO Yanlong¹, ZHAO Lei¹, SHI Yongfeng¹, LIU Ning¹, LIU Yongli¹, LIU Bin¹, XU Qinghua², HE Chaoliang², CHEN Xuesi²

1. The Second Hospital of Jilin University, Changchun 130041, P. R. China;
2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Received:2015-01-20 Revised:2015-04-08 Online:2015-08-01 Published:2015-04-13
Contact: LIU Bin E-mail:liubin3333@vip.sina.com
Supported by:
Supported by the Bethune Frontier Interdisciplinary Innovation Project of Jilin University, China(No.2013106020).

摘要/Abstract

摘要：

Percutaneous coronary intervention(PCI) has become an important method for the treatment of the patients with coronary heart disease; however, problems, such as vascular endothelial inflammation, late thrombosis, and stent restenosis still exist as a result of poor biocompatibility of the materials. To enhance the biocompatibility, methoxy poly(ethylene glycol)(mPEG) was immobilized on the surface of AISI 316 grade stainless steel(SS)(AISI: American Iron and Steel Institute). First, silanized mPEG was synthesized by the direct coupling of mPEG with 3-isocyanatopropyltriethoxysilane(IPTS) via urethane bonds, and the silanized mPEG was then grafted on the surface of SS that was hydroxylated with piranha solution. The results obtained from contact angle goniometry, X-ray photoelectron spectroscopy(XPS), and atomic force microscopy(AFM) confirm that the mPEG modified steel contained more C and Si and less Fe and Cr on its surface, exhibiting a morphological change and decrease in the contact angle. The biocompatibility of the mPEG modified SS was evaluated with fibrinogen adsorption, platelet activation and adhesion, and human umbilical vein endothelial cell(HUVEC) adhesion. Fibrinogen adsorption, platelet activation, and adhesion were clearly suppressed on the surface-modified steel. In addition, human umbilical vein endothelial cell(HUVEC) could adhere and proliferate on the surface of the mPEG-modified SS. This study indicates that the modification of 316L SS with mPEG could enhance the biocompatibility and provide a primary experimental foundation for the development of next-generation coronary stent materials for clinical application.

关键词: 316L stainless steel, Methoxy poly(ethylene glycol)(mPEG), Surface modification, Biocompatibility

Abstract:

Key words: 316L stainless steel, Methoxy poly(ethylene glycol)(mPEG), Surface modification, Biocompatibility

XIAO Yanlong, ZHAO Lei, SHI Yongfeng, LIU Ning, LIU Yongli, LIU Bin, XU Qinghua, HE Chaoliang, CHEN Xuesi. Surface Modification of 316L Stainless Steel by Grafting Methoxy Poly(ethylene glycol) to Improve the Biocompatibility[J]. 高等学校化学研究, 2015, 31(4): 651-657.

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Surface Modification of 316L Stainless Steel by Grafting Methoxy Poly(ethylene glycol) to Improve the Biocompatibility

Surface Modification of 316L Stainless Steel by Grafting Methoxy Poly(ethylene glycol) to Improve the Biocompatibility

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