Artificial Nucleotide-containing Aptamers Used in Tumor Therapy

doi:10.1007/s40242-019-0033-2

高等学校化学研究 ›› 2020, Vol. 36 ›› Issue (2): 164-170.doi: 10.1007/s40242-019-0033-2

Artificial Nucleotide-containing Aptamers Used in Tumor Therapy

QIN Xinyuan², SU Yuanye¹, TAN Jie¹, YUAN Quan^1,2

1. Institute of Chemical Biology and Nanomedicine(ICBN), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha 410082, P. R. China;
2. Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China

收稿日期:2019-10-31 修回日期:2019-11-14 出版日期:2020-04-01 发布日期:2019-11-29
通讯作者: TAN Jie, YUAN Quan E-mail:yuanquan@whu.edu.cn;tanjie0416@hnu.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(Nos.21904037, 21675120) and the National Key R&D Program of China(No.2017YFA0208000).

Artificial Nucleotide-containing Aptamers Used in Tumor Therapy

QIN Xinyuan², SU Yuanye¹, TAN Jie¹, YUAN Quan^1,2

1. Institute of Chemical Biology and Nanomedicine(ICBN), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha 410082, P. R. China;
2. Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China

Received:2019-10-31 Revised:2019-11-14 Online:2020-04-01 Published:2019-11-29
Contact: TAN Jie, YUAN Quan E-mail:yuanquan@whu.edu.cn;tanjie0416@hnu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21904037, 21675120) and the National Key R&D Program of China(No.2017YFA0208000).

摘要/Abstract

摘要： The high pharmaceutical cost and multi-drug resistance in tumor therapeutic agents hinder the further application of chemotherapy in tumor therapy. Artificial modified nucleic acid aptamers have the advantages of high binding affinity, programmability, and easy synthesis. Thus, the rational design of artificial modified aptamers is expected to provide a versatile platform for the optimization of chemotherapy agents. In this review, we summarize the modification strategies and the application of the artificial modified nucleotide-containing aptamers, aiming to provide a promising step toward aptamer-related chemotherapeutic agents.

关键词: Aptamer, Artificial nucleotide, Functional nucleic acid

Abstract: The high pharmaceutical cost and multi-drug resistance in tumor therapeutic agents hinder the further application of chemotherapy in tumor therapy. Artificial modified nucleic acid aptamers have the advantages of high binding affinity, programmability, and easy synthesis. Thus, the rational design of artificial modified aptamers is expected to provide a versatile platform for the optimization of chemotherapy agents. In this review, we summarize the modification strategies and the application of the artificial modified nucleotide-containing aptamers, aiming to provide a promising step toward aptamer-related chemotherapeutic agents.

Key words: Aptamer, Artificial nucleotide, Functional nucleic acid

QIN Xinyuan, SU Yuanye, TAN Jie, YUAN Quan. Artificial Nucleotide-containing Aptamers Used in Tumor Therapy[J]. 高等学校化学研究, 2020, 36(2): 164-170.

QIN Xinyuan, SU Yuanye, TAN Jie, YUAN Quan. Artificial Nucleotide-containing Aptamers Used in Tumor Therapy[J]. Chemical Research in Chinese Universities, 2020, 36(2): 164-170.

参考文献 75

[1]	Tian T., Li J., Xie C., Sun Y., Lei H., Liu X., Xia J., Shi J., Wang L., Lu W., Fan C., ACS Applied Materials & Interfaces, 2018, 10(4), 3414
[2]	Zeng X., Luo M., Liu G., Wang X., Tao W., Lin Y., Ji X., Nie L., Mei L., Advanced Science, 2018, 5(10), 1800510
[3]	Bian Q., Wang W., Wang S., Wang G., ACS Applied Materials & Interfaces, 2016, 8(40), 27360
[4]	Wang J., Wang Y., Hu X., Zhu C., Ma Q., Liang L., Li Z., Yuan Q., Analytical Chemistry, 2019, 91(1), 823
[5]	Wang J., Shen H., Huang C., Ma Q., Tan Y., Jiang F., Ma C., Yuan Q., Nano Research, 2016, 10(1), 145
[6]	Hu X., Wang Y., Tan Y., Wang J., Liu H., Wang Y., Yang S., Shi M., Zhao S., Zhang Y., Yuan Q., Advanced Materials, 2017, 29(15), 1605235
[7]	Wang J., Wei Y., Hu X., Fang Y. Y., Li X., Liu J., Wang S., Yuan Q., Journal of the American Chemical Society, 2015, 137(33), 10576
[8]	Zhang H., Li B., Sun Z., Zhou H., Zhang S., Chemical Science, 2017, 8(12), 8025
[9]	Qiu L., Chen T., Ocsoy I., Yasun E., Wu C., Zhu G., You M., Han D., Jiang J., Yu R., Tan W., Nano Letters, 2015, 15(1), 457
[10]	He J., Dong J., Hu Y., Li G., Hu Y., Nanoscale, 2019, 11(13), 6089
[11]	Chandrasekaran R., Lee A. S., Yap L. W., Jans D. A., Wagstaff K. M., Cheng W., Nanoscale, 2016, 8(1), 187
[12]	Jiang Y., Pan X., Chang J., Niu W., Hou W., Kuai H., Zhao Z., Liu J., Wang M., Tan W., Journal of the American Chemical Society, 2018, 140(22), 6780
[13]	Song Y., Tang C., Yin C., Biomaterials, 2018, 150, 1
[14]	Ren X., Gelinas A. D., von Carlowitz I., Janjic N., Pyle A. M., Nature Communications, 2017, 8(1), 810
[15]	Zhao N., Pei S. N., Qi J., Zeng Z., Iyer S. P., Lin P., Tung C. H., Zu Y., Biomaterials, 2015, 67, 42
[16]	Zhang J., Chen R., Fang X., Chen F., Wang Y., Chen M., Nano Research, 2015, 8(1), 201
[17]	Cogoi S., Jakobsen U., Pedersen E. B., Vogel S., Xodo L. E., Scientific Reports, 2016, 6, 38468
[18]	Setoguchi K., Cui L., Hachisuka N., Obchoei S., Shinkai K., Hyodo F., Kato K., Wada F., Yamamoto T., Harada-Shiba M., Obika S., Nakano K., Molecular Therapy. Nucleic Acids, 2017, 9, 170
[19]	Yang Y., Yang X., Yang Y., Yuan Q., Carbon, 2018, 129, 380
[20]	Tao W., Zeng X., Wu J., Zhu X., Yu X., Zhang X., Zhang J., Liu G., Mei L., Theranostics, 2016, 6(4), 470
[21]	Tagalakis A. D., Maeshima R., Yu-Wai-Man C., Meng J., Syed F., Wu L. P., Aldossary A. M., McCarthy D., Moghimi S. M., Hart S. L., Acta Biomaterialia, 2017, 51, 351
[22]	Hwang D. W., Kim H. Y., Li F., Park J. Y., Kim D., Park J. H., Han H. S., Byun J. W., Lee Y. S., Jeong J. M., Char K., Lee D. S., Biomaterials, 2017, 121, 144
[23]	Huang K. W., Lai Y. T., Chern G. J., Huang S. F., Tsai C. L., Sung Y. C., Chiang C. C., Hwang P. B., Ho T. L., Huang R. L., Shiue T. Y., Chen Y., Wang S. K., Biomacromolecules, 2018, 19(6), 2330
[24]	Li J., Hong C. Y., Wu S. X., Liang H., Wang L. P., Huang G., Chen X., Yang H. H., Shangguan D., Tan W., Journal of the American Chemical Society, 2015, 137(35), 11210
[25]	Jing P., Cao S., Xiao S., Zhang X., Ke S., Ke F., Yu X., Wang L., Wang S., Luo Y., Zhong Z., Cancer Letters, 2016, 383(2), 230
[26]	Chen D., Li B., Cai S., Wang P., Peng S., Sheng Y., He Y., Gu Y., Chen H., Biomaterials, 2016, 100, 1
[27]	Zhang Y., Hou Z., Ge Y., Deng K., Liu B., Li X., Li Q., Cheng Z., Ma P., Li C., Lin J., ACS Applied Materials & Interfaces, 2015, 7(37), 20696
[28]	Li F., Mei H., Gao Y., Xie X., Nie H., Li T., Zhang H., Jia L., Biomaterials, 2017, 145, 56
[29]	Peng L. H., Zhang Y. H., Han L. J., Zhang C. Z., Wu J. H., Wang X. R., Gao J. Q., Mao Z. W., ACS Applied Materials & Interfaces, 2015, 7(33), 18628
[30]	Hili R., Niu J., Liu D. R., Journal of the American Chemical Society, 2013, 135(1), 98
[31]	Zhao F., Zhou J., Su X., Wang Y., Yan X., Jia S., Du B., Small, 2017, 13(20), 1603990
[32]	Wang R., Lu D., Bai H., Jin C., Yan G., Chemical Science, 2016, 7(3), 2157
[33]	Wang R. W., Wang C. M., Cao Y., Zhu Z., Yang C. Y., Chemical Science, 2014, 5(10), 4076
[34]	Kimoto M., Yamashige R., Matsunaga K., Yokoyama S., Hirao I., Nature Biotechnology, 2013, 31(5), 453
[35]	Matsunaga K. I., Kimoto M., Hirao I., Journal of the American Chemical Society, 2017, 139(1), 324
[36]	Biondi E., Lane J. D., Das D., Dasgupta S., Piccirilli J. A., Hoshika S., Bradley K. M., Krantz B. A., Benner S. A., Nucleic. Acids Research, 2016, 44(20), 9565
[37]	Labenski V., Suerth J. D., Barczak E., Heckl D., Levy C., Bernadin O., Charpentier E., Williams D. A., Fehse B., Verhoeyen E., Schambach A., Biomaterials, 2016, 97, 97
[38]	Hou W., Liu Y., Jiang Y., Wu Y., Cui C., Wang Y., Zhang L., Teng I. T., Tan W., Nanoscale, 2018, 10(23), 10986
[39]	Chen W., Liu X., Xiao Y., Tang R., Small, 2015, 11(15), 1775
[40]	Khaled S. Z., Cevenini A., Yazdi I. K., Parodi A., Evangelopoulos M., Corbo C., Scaria S., Hu Y., Haddix S. G., Corradetti B., Salvatore F., Tasciotti E., Biomaterials, 2016, 87, 57
[41]	Kanlikilicer P., Ozpolat B., Aslan B., Bayraktar R., Gurbuz N., Rodriguez-Aguayo C., Bayraktar E., Denizli M., Gonzalez-Villasana V., Ivan C., Lokesh G. L. R., Amero P., Catuogno S., Haemmerle M., Wu S. Y., Mitra R., Gorenstein D. G., Volk D. E., de Franciscis V., Sood A. K., Lopez-Berestein G., Molecular Therapy. Nucleic Acids, 2017, 9, 251
[42]	Zhang F., Correia A., Makila E., Li W., Salonen J., Hirvonen J. J., Zhang H., Santos H. A., ACS Applied Materials & Interfaces, 2017, 9(11), 10034
[43]	Abnous K., Danesh N. M., Ramezani M., Yazdian-Robati R., Alibolandi M., Taghdisi S. M., Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13(6), 1933
[44]	Li N., Xiang M. H., Liu J. W., Tang H., Jiang J. H., Analytical Chemistry, 2018, 90(21), 12951
[45]	Li Y., Liu R., Shi Y., Zhang Z., Zhang X., Theranostics, 2015, 5(6), 583
[46]	Ozes A. R., Wang Y., Zong X., Fang F., Pilrose J., Nephew K. P., Scientific Reports, 2017, 7(1), 894
[47]	Wang S., Sun C., Li J., Zhang E., Ma Z., Xu W., Li H., Qiu M., Xu Y., Xia W., Xu L., Yin R., Cancer Letters, 2017, 408, 112
[48]	Wan J., Geng S., Zhao H., Peng X., Xu J., Wei M., Mao J., Zhou Y., Zhu Q., Zhao Y., Yang X., Nanoscale, 2018, 10(42), 20020
[49]	He B., Wang Y., Shao N., Chang H., Cheng Y., Acta Biomaterialia, 2015, 22, 111
[50]	Fan X., Sun L., Wu Y., Zhang L., Yang Z., Scientific Reports, 2016, 6, 25799
[51]	Matsunaga K., Kimoto M., Hanson C., Sanford M., Young H. A., Hirao I., Scientific Reports, 2015, 5, 18478
[52]	Cogoi S., Zorzet S., Rapozzi V., Geci I., Pedersen E. B., Xodo L. E., Nucleic Acids Research, 2013, 41(7), 4049
[53]	Xie H., Zhan H., Gao Q., Li J., Zhou Q., Chen Z., Liu Y., Ding M., Xiao H., Liu Y., Huang W., Cai Z., Cancer Letters, 2018, 422, 94
[54]	McNamara J. O., Kolonias D., Pastor F., Mittler R. S., Chen L., Giangrande P. H., Sullenger B., Gilboa E., The Journal of Clinical Investigation, 2008, 118(1), 376
[55]	Seo Y. E., Suh H. W., Bahal R., Josowitz A., Zhang J., Song E., Cui J., Noorbakhsh S., Jackson C., Bu T., Piotrowski-Daspit A., Bindra R., Saltzman W. M., Biomaterials, 2019, 201, 87
[56]	Sun Q., Kang Z., Xue L., Shang Y., Su Z., Sun H., Ping Q., Mo R., Zhang C., Journal of the American Chemical Society, 2015, 137(18), 6000
[57]	Durso M., Gaglione M., Piras L., Mercurio M. E., Terreri S., Olivieri M., Marinelli L., Novellino E., Incoronato M., Grieco P., Orsini G., Tonon G., Messere A., Cimmino A., European Journal of Medicinal Chemistry, 2016, 111, 15
[58]	Dassie J. P., Liu X. Y., Thomas G. S., Whitaker R. M., Thiel K. W., Stockdale K. R., Meyerholz D. K., McCaffrey A. P., McNamara J. O., Giangrande P. H., Nature Biotechnology, 2009, 27(9), 839
[59]	Westerlund K., Vorobyeva A., Mitran B., Orlova A., Tolmachev V., Karlstrom A. E., Altai M., Biomaterials, 2019, 203, 73
[60]	Gasparello J., Manicardi A., Casnati A., Corradini R., Gambari R., Finotti A., Sansone F., Scientific Reports, 2019, 9(1), 3036
[61]	Li L., Hu X., Zhang M., Ma S., Yu F., Zhao S., Liu N., Wang Z., Wang Y., Guan H., Pan X., Gao Y., Zhang Y., Liu Y., Yang Y., Tang X., Li M., Liu C., Li Z., Mei X., Molecular Therapy. Nucleic Acids, 2017, 8, 169
[62]	Gupta A., Quijano E., Liu Y., Bahal R., Scanlon S. E., Song E., Hsieh W. C., Braddock D. E., Ly D. H., Saltzman W. M., Glazer P. M., Molecular Therapy. Nucleic Acids, 2017, 9, 111
[63]	Chen W. H., Yang S. S., Fadeev M., Cecconello A., Nechushtai R., Willner I., Nanoscale, 2018, 10(10), 4650
[64]	Kratschmer C., Levy M., Molecular Therapy. Nucleic Acids, 2018, 10, 227
[65]	Wang K., Yao H., Meng Y., Wang Y., Yan X., Huang R., Acta Biomaterialia, 2015, 16, 196
[66]	He X., Chen X., Liu L., Zhang Y., Lu Y., Zhang Y., Chen Q., Ruan C., Guo Q., Li C., Sun T., Jiang C., Advanced Science, 2018, 5(5), 1701070
[67]	Li L. L., Xie M., Wang J., Li X., Wang C., Yuan Q., Pang D. W., Lu Y., Tan W., Chemical Communications, 2013, 49(52), 5823
[68]	Yang Y., Liu J., Sun X., Feng L., Zhu W., Liu Z., Chen M., Nano Research, 2015, 9(1), 139
[69]	Kong L., Qiu J., Sun W., Yang J., Shen M., Wang L., Shi X., Biomaterials Science, 2017, 5(2), 258
[70]	Zhan Y., Ma W., Zhang Y., Mao C., Shao X., Xie X., Wang F., Liu X., Li Q., Lin Y., ACS Applied Materials & Interfaces, 2019, 11(17), 15354
[71]	Taghavi S., Ramezani M., Alibolandi M., Abnous K., Taghdisi S. M., Cancer Letters, 2017, 400, 1
[72]	Yuan Q., Wu Y., Wang J., Lu D., Zhao Z., Liu T., Zhang X., Tan W., Angewandte Chemie, 2013, 52(52), 13965
[73]	Pi F., Zhang H., Li H., Thiviyanathan V., Gorenstein D. G., Sood A. K., Guo P., Nanomedicine : Nanotechnology, Biology, and Medicine, 2017, 13(3), 1183
[74]	Ma Y., Zhao W., Li Y., Pan Y., Wang S., Zhu Y., Kong L., Guan Z., Wang J., Zhang L., Yang Z., Biomaterials, 2019, 197, 182
[75]	Bertucci A., Prasetyanto E. A., Septiadi D., Manicardi A., Brognara E., Gambari R., Corradini R., de Cola L., Small, 2015, 11(42), 5687

Artificial Nucleotide-containing Aptamers Used in Tumor Therapy

Artificial Nucleotide-containing Aptamers Used in Tumor Therapy

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