Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure

doi:10.1007/s40242-019-9162-x

高等学校化学研究 ›› 2019, Vol. 35 ›› Issue (6): 978-982.doi: 10.1007/s40242-019-9162-x

Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure

PENG Bo, FU Shiguo, LI Yanxia, ZHANG Junhui, XIE Shengming, LI Li, LYU Yun, DUAN Aihong, CHEN Xuexian, YUAN Liming

Department of Chemistry, Yunnan Normal University, Kunming 650500, P. R. China

收稿日期:2019-06-06 修回日期:2019-09-10 出版日期:2019-12-01 发布日期:2019-11-29
通讯作者: YUAN Liming E-mail:yuan_limingpd@126.com
基金资助:
Supported by the National Natural Science Foundation of China(Nos.21675141, 21665028, 91856123).

Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure

PENG Bo, FU Shiguo, LI Yanxia, ZHANG Junhui, XIE Shengming, LI Li, LYU Yun, DUAN Aihong, CHEN Xuexian, YUAN Liming

Department of Chemistry, Yunnan Normal University, Kunming 650500, P. R. China

Received:2019-06-06 Revised:2019-09-10 Online:2019-12-01 Published:2019-11-29
Contact: YUAN Liming E-mail:yuan_limingpd@126.com
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21675141, 21665028, 91856123).

摘要/Abstract

摘要： Highly-ordered inorganic chiral mesoporous silica(HOCMS) has attracted substantial interest in recent decades. High performance liquid chromatography(HPLC) is the most important approach for the separation of enantiomers and herein reported an HPLC chiral stationary phase composed of HOCMS. The column was fabricated by conventional high pressure slurry packing. Eighteen racemates, including alcohols, ketones, amines, aldehydes and organic acids, were resolved on the column. Good chiral separations of hydrobenzoin, metoprolol, propranolol hydrochloride, 4-methyl-2-pentanol, omeprazole, 2,2'-furoin and ketoprofen were obtained. The relative standard deviations for five replicate separations of racemates were 0.1%-0.16% for retention time and 1.73%-2.64% for peak areas. The results suggest that HOCMS is a promising candidate for preparation of chiral stationary phases for HPLC.

关键词: Highly-ordered inorganic chiral mesoporous silica, Chiral stationary phase, High performance liquid chromatography, Enantioseparation

Abstract: Highly-ordered inorganic chiral mesoporous silica(HOCMS) has attracted substantial interest in recent decades. High performance liquid chromatography(HPLC) is the most important approach for the separation of enantiomers and herein reported an HPLC chiral stationary phase composed of HOCMS. The column was fabricated by conventional high pressure slurry packing. Eighteen racemates, including alcohols, ketones, amines, aldehydes and organic acids, were resolved on the column. Good chiral separations of hydrobenzoin, metoprolol, propranolol hydrochloride, 4-methyl-2-pentanol, omeprazole, 2,2'-furoin and ketoprofen were obtained. The relative standard deviations for five replicate separations of racemates were 0.1%-0.16% for retention time and 1.73%-2.64% for peak areas. The results suggest that HOCMS is a promising candidate for preparation of chiral stationary phases for HPLC.

Key words: Highly-ordered inorganic chiral mesoporous silica, Chiral stationary phase, High performance liquid chromatography, Enantioseparation

PENG Bo, FU Shiguo, LI Yanxia, ZHANG Junhui, XIE Shengming, LI Li, LYU Yun, DUAN Aihong, CHEN Xuexian, YUAN Liming. Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure[J]. 高等学校化学研究, 2019, 35(6): 978-982.

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Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure

Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure

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