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高等学校化学研究 ›› 2013, Vol. 29 ›› Issue (4): 647-652.doi: 10.1007/s40242-013-2516-x

• Articles • 上一篇    下一篇

Ionic Liquid-based Microwave-assisted Liquid-liquid Microextraction and High Performance Liquid Chromatography Determination of Sulfonamides from Animal Oils

FENG Xu-dong1, LIANG Fang-hui2, SU Rui1, WU Li-jie1, LI Xue-yuan1, WANG Xing-hua1, ZHANG Han-qi1, YU Ai-min1   

  1. 1. College of Chemistry, Jilin University, Changchun 130012, P. R. China;
    2. Department of Pharmacy, Changchun Medical College, Changchun 130117, P. R. China
  • 收稿日期:2012-12-21 修回日期:2013-03-12 出版日期:2013-08-01 发布日期:2013-07-15
  • 通讯作者: YU Ai-min E-mail:yu_anal@163.com
  • 基金资助:

    Supported by the Key Projects of Science and Technology Development Plan of Jilin Province, China(No.20125006) and the Scientific Forefront and Interdisciplinary Innovation Project of Jilin University, China(No.450060481018).

Ionic Liquid-based Microwave-assisted Liquid-liquid Microextraction and High Performance Liquid Chromatography Determination of Sulfonamides from Animal Oils

FENG Xu-dong1, LIANG Fang-hui2, SU Rui1, WU Li-jie1, LI Xue-yuan1, WANG Xing-hua1, ZHANG Han-qi1, YU Ai-min1   

  1. 1. College of Chemistry, Jilin University, Changchun 130012, P. R. China;
    2. Department of Pharmacy, Changchun Medical College, Changchun 130117, P. R. China
  • Received:2012-12-21 Revised:2013-03-12 Online:2013-08-01 Published:2013-07-15
  • Contact: YU Ai-min E-mail:yu_anal@163.com
  • Supported by:

    Supported by the Key Projects of Science and Technology Development Plan of Jilin Province, China(No.20125006) and the Scientific Forefront and Interdisciplinary Innovation Project of Jilin University, China(No.450060481018).

被引次数

19

摘要：

The authors performed ionic liquid-based microwave-assisted liquid-liquid microextraction(IL-based MALLME) coupled with high performance liquid chromatographic separation for the determination of 6 sulfonamides (SAs) from animal oils. The target analytes were extracted from animal oil samples with sodium hydroxide solution containing 1-butyl-3-methylimidazolium tetrafluoroborateand as the extraction solvent under microwave irradiation. The experimental parameters of the IL-based MALLME, including types of ILs, volume of IL, amount of ion-pairing agent(NH4PF6), pH value of sample solution, and extraction temperature and time were evaluated. The limits of detection and quantification obtained were in a range of 0.4―0.5 μg/kg and a range of 1.2―1.8 μg/kg, respectively. The accuracy of the method was evaluated by analyzing five spiked animal oil samples at two fortified levels(5 and 50 μg/kg), and the recoveries of SAs varied from 81.4% to 114.5% with relative standard deviations ranging from 0.8% to 9.0%.

关键词: Ionic liquid-based microwave-assisted liquid-liquid microextraction(IL-based MALLME), High performance liquid chromatography(HPLC), Sulfonamide, Animal oil

Abstract:

The authors performed ionic liquid-based microwave-assisted liquid-liquid microextraction(IL-based MALLME) coupled with high performance liquid chromatographic separation for the determination of 6 sulfonamides (SAs) from animal oils. The target analytes were extracted from animal oil samples with sodium hydroxide solution containing 1-butyl-3-methylimidazolium tetrafluoroborateand as the extraction solvent under microwave irradiation. The experimental parameters of the IL-based MALLME, including types of ILs, volume of IL, amount of ion-pairing agent(NH4PF6), pH value of sample solution, and extraction temperature and time were evaluated. The limits of detection and quantification obtained were in a range of 0.4―0.5 μg/kg and a range of 1.2―1.8 μg/kg, respectively. The accuracy of the method was evaluated by analyzing five spiked animal oil samples at two fortified levels(5 and 50 μg/kg), and the recoveries of SAs varied from 81.4% to 114.5% with relative standard deviations ranging from 0.8% to 9.0%.

Key words: Ionic liquid-based microwave-assisted liquid-liquid microextraction(IL-based MALLME), High performance liquid chromatography(HPLC), Sulfonamide, Animal oil