Synthesis of Resveratrol Analogs/Stilbene Derivatives and Their Nitric Oxide Inhibitory and Radical Scavenging Activities

doi:10.1007/s40242-014-4120-0

高等学校化学研究 ›› 2014, Vol. 30 ›› Issue (6): 941-946.doi: 10.1007/s40242-014-4120-0

Synthesis of Resveratrol Analogs/Stilbene Derivatives and Their Nitric Oxide Inhibitory and Radical Scavenging Activities

WANG Jue¹, ZHANG Cunlong³, WANG Tiejie¹, LI Xiaofan²

1. Shenzhen Institute for Drug Control, Shenzhen 518057, P. R. China;
2. Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, P. R. China;
3. Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China

收稿日期:2014-04-04 修回日期:2014-08-18 出版日期:2014-12-01 发布日期:2014-09-01
通讯作者: LI Xiaofan E-mail:lixiaof@szu.edu.cn
基金资助:
Supported by the Shenzhen Science and Technology Program, China(No.JCYJ20120830153011458), the Project of the Educational Commission of Guangdong Province of China(No.2013KJCX0164) and the Natural Science Foundation of Shenzhen Universitiy, China(No.00036159).

Synthesis of Resveratrol Analogs/Stilbene Derivatives and Their Nitric Oxide Inhibitory and Radical Scavenging Activities

WANG Jue¹, ZHANG Cunlong³, WANG Tiejie¹, LI Xiaofan²

1. Shenzhen Institute for Drug Control, Shenzhen 518057, P. R. China;
2. Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, P. R. China;
3. Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China

Received:2014-04-04 Revised:2014-08-18 Online:2014-12-01 Published:2014-09-01
Contact: LI Xiaofan E-mail:lixiaof@szu.edu.cn
Supported by:
Supported by the Shenzhen Science and Technology Program, China(No.JCYJ20120830153011458), the Project of the Educational Commission of Guangdong Province of China(No.2013KJCX0164) and the Natural Science Foundation of Shenzhen Universitiy, China(No.00036159).

摘要/Abstract

摘要：

Sixteen resveratrol analogs(stilbene derivatives) including resveratrol were synthesized, in which hydroxystilbenes, naturally occurring polyphenols, showed protective effects against reactive oxygen and nitrogen species(ROS/RNS) and hexahydroxystilbene(16) displayed the strongest activities against NO and 1,1-diphenyl- 2-picrylhydrazyl(DPPH) with IC₅₀ values of 7.8 and 5.7 μmol/L, respectively.

关键词: Resveratrol, Stilbene, Nitric oxide, Radical

Abstract:

Key words: Resveratrol, Stilbene, Nitric oxide, Radical

WANG Jue, ZHANG Cunlong, WANG Tiejie, LI Xiaofan. Synthesis of Resveratrol Analogs/Stilbene Derivatives and Their Nitric Oxide Inhibitory and Radical Scavenging Activities[J]. 高等学校化学研究, 2014, 30(6): 941-946.

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Synthesis of Resveratrol Analogs/Stilbene Derivatives and Their Nitric Oxide Inhibitory and Radical Scavenging Activities

Synthesis of Resveratrol Analogs/Stilbene Derivatives and Their Nitric Oxide Inhibitory and Radical Scavenging Activities

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