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高等学校化学研究 ›› 2011, Vol. 27 ›› Issue (6): 1078-1082.

• Articles • 上一篇    

PEG-grafted PVA Membrane and Its Blood Compatibility

JIN Gu*, YAO Qi-zhi, DONG Li-quan and MA Feng   

  1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China
  • 收稿日期:2011-01-07 修回日期:2011-08-18 出版日期:2011-11-25 发布日期:2011-11-07
  • 通讯作者: JIN Gu E-mail:gjin@ustc.edu.cn
  • 基金资助:

    Supported by the National Natural Science Foundation of China(No.29405038).

PEG-grafted PVA Membrane and Its Blood Compatibility

JIN Gu*, YAO Qi-zhi, DONG Li-quan and MA Feng   

  1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China
  • Received:2011-01-07 Revised:2011-08-18 Online:2011-11-25 Published:2011-11-07
  • Contact: JIN Gu E-mail:gjin@ustc.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.29405038).

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被引次数

15

摘要： Preparation and blood compatibility of different shape polyvinyl alcohol(PVA) membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene(PTFE) capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol(mPEG) was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The  experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.

关键词: Polyvinyl alcohol(PVA), Polyethylene glycol(PEG), Membrane, Platelet, Adhesion

Abstract: Preparation and blood compatibility of different shape polyvinyl alcohol(PVA) membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene(PTFE) capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol(mPEG) was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The  experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.

Key words: Polyvinyl alcohol(PVA), Polyethylene glycol(PEG), Membrane, Platelet, Adhesion