Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones

高等学校化学研究 ›› 2006, Vol. 22 ›› Issue (4): 468-473.

Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones

ZHAO Yan-fang, ZHAI Xin, CHEN Jiao-yue, GUO Shu-chun, GONG Ping

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China

收稿日期:2005-06-13 出版日期:2006-08-24 发布日期:2011-08-06
基金资助:
Supported by the Natural Science Foundation of Liaoning Province(No. 20032043).

Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones

ZHAO Yan-fang, ZHAI Xin, CHEN Jiao-yue, GUO Shu-chun, GONG Ping

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China

Received:2005-06-13 Online:2006-08-24 Published:2011-08-06
Supported by:
Supported by the Natural Science Foundation of Liaoning Province(No. 20032043).

摘要/Abstract

摘要： A series of novel pyrazolo[4,3-d]pyrimidin-7-ones was designed and synthesized in order to find new potent phosphodiesterase 5 inhibitors(PDE5). The structures of all the compounds were confirmed by IR, ¹H NMR and MS; their in vitro vasodilatory activities were tested on isolated rabbit aortic spiral strips. Among them, compound Ⅹ3 displays a significant vasodilatory activity, which is more potent than verapamil.

关键词: Pyrazolo[4, 3-d]pyrimidin-7-one, Synthesis, Vasodilatory activity

Abstract: A series of novel pyrazolo[4,3-d]pyrimidin-7-ones was designed and synthesized in order to find new potent phosphodiesterase 5 inhibitors(PDE5). The structures of all the compounds were confirmed by IR, ¹H NMR and MS; their in vitro vasodilatory activities were tested on isolated rabbit aortic spiral strips. Among them, compound Ⅹ3 displays a significant vasodilatory activity, which is more potent than verapamil.

Key words: Pyrazolo[4,3-d]pyrimidin-7-one, Synthesis, Vasodilatory activity

ZHAO Yan-fang, ZHAI Xin, CHEN Jiao-yue, GUO Shu-chun, GONG Ping. Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones[J]. 高等学校化学研究, 2006, 22(4): 468-473.

ZHAO Yan-fang, ZHAI Xin, CHEN Jiao-yue, GUO Shu-chun, GONG Ping. Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones[J]. Chemical Research in Chinese Universities, 2006, 22(4): 468-473.

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Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones

Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones

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