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高等学校化学研究 ›› 2005, Vol. 21 ›› Issue (2): 141-144.

• Articles • 上一篇    下一篇

Determination of 6-Mercaptopurine in Rat Blood by Microdialysis Coupled with High Performance Liquid Chromatography on a Functionalized Multi-wall Carbon Nanotubes Modified Electrode

LIN Li1, QIU Pei-hong1, XIE Xia-feng1, CAO Xu-ni2, JIN Li-tong2   

  1. 1. Department of Chemistry, Wenzhou Medical College, Wenzhou 325035, P. R. China;
    2. Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China
  • 收稿日期:2004-02-28 出版日期:2005-03-24 发布日期:2011-07-27

Determination of 6-Mercaptopurine in Rat Blood by Microdialysis Coupled with High Performance Liquid Chromatography on a Functionalized Multi-wall Carbon Nanotubes Modified Electrode

LIN Li1, QIU Pei-hong1, XIE Xia-feng1, CAO Xu-ni2, JIN Li-tong2   

  1. 1. Department of Chemistry, Wenzhou Medical College, Wenzhou 325035, P. R. China;
    2. Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China
  • Received:2004-02-28 Online:2005-03-24 Published:2011-07-27

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摘要： A new chemically modified electrode(CME) immobilized on the surface of multi-wall carbon nanotubes functionalized with carboxylic groups was fabricated.The results indicate that the CME exhibits efficiently electrocatalytic oxidation of 6-mercaptopurine(6-MP).The CME can be used as the working electrode in the liquid chromatography for the determination of 6-MP.The peak current of 6-MP is linearly changed with its concentration ranging from 4.0×10-7 to 1.0×10-4 mol/L with the calculated detection limit (S/N=3) of 2.0×10-7 mol/L.Coupled with microdialysis sampling, the method has been successfully applied to assessing the content of 6-MP in rat blood.

关键词: 6-Mercaptopurine, Multi-wall carbon nanotube, Chemical modified electrode, HPLC, Microdialysis sampling

Abstract: A new chemically modified electrode(CME) immobilized on the surface of multi-wall carbon nanotubes functionalized with carboxylic groups was fabricated.The results indicate that the CME exhibits efficiently electrocatalytic oxidation of 6-mercaptopurine(6-MP).The CME can be used as the working electrode in the liquid chromatography for the determination of 6-MP.The peak current of 6-MP is linearly changed with its concentration ranging from 4.0×10-7 to 1.0×10-4 mol/L with the calculated detection limit (S/N=3) of 2.0×10-7 mol/L.Coupled with microdialysis sampling, the method has been successfully applied to assessing the content of 6-MP in rat blood.

Key words: 6-Mercaptopurine, Multi-wall carbon nanotube, Chemical modified electrode, HPLC, Microdialysis sampling