Differential Antibacterial Effects of Chiral Co3O4

doi:10.1007/s40242-024-4036-2

高等学校化学研究 ›› 2024, Vol. 40 ›› Issue (6): 1134-1140.doi: 10.1007/s40242-024-4036-2

Differential Antibacterial Effects of Chiral Co₃O₄

SUN Jia^1,2, SONG Shanshan^1,2, GUO Caoyu^1,2, LIU Liqiang^1,2, SUN Maozhong^1,2, KUANG Hua^1,2, XU Chuanlai^1,2, GUO Lingling^1,2

1. State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, P. R. China;
2. International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China

收稿日期:2024-02-22 出版日期:2024-12-01 发布日期:2024-10-26
通讯作者: GUO Lingling,gling0329@jiangnan.edu.cn E-mail:gling0329@jiangnan.edu.cn
基金资助:
This work was supported by the National Key R&D Program of China (No. 2022YFF1102600).

Differential Antibacterial Effects of Chiral Co₃O₄

SUN Jia^1,2, SONG Shanshan^1,2, GUO Caoyu^1,2, LIU Liqiang^1,2, SUN Maozhong^1,2, KUANG Hua^1,2, XU Chuanlai^1,2, GUO Lingling^1,2

1. State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, P. R. China;
2. International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China

Received:2024-02-22 Online:2024-12-01 Published:2024-10-26
Contact: GUO Lingling,gling0329@jiangnan.edu.cn E-mail:gling0329@jiangnan.edu.cn
Supported by:
This work was supported by the National Key R&D Program of China (No. 2022YFF1102600).

摘要/Abstract

摘要： With the global spread of antimicrobial resistance, it is imperative to satisfy the need to develop novel antibacterial agents. Here, we synthesized chiral Co₃O₄ nanoparticles (NPs) with obvious bactericidal effects. It was found that the circular dichroism (CD) spectra of L-Co₃O₄ NPs and D-Co₃O₄ NPs exhibited perfect mirror image inversion. Specifically, the survival rate of primary uterine fibroblast (PCS) cells reached above 90% by co-culturing with chiral Co₃O₄ NPs. Besides, the chiral Co₃O₄ NPs showed obvious killing ability on Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli O157:H7) bacteria both in vitro and in vivo. Particularly, D-Co₃O₄ NPs showed better antibacterial activity. Mechanistic studies confirmed that the level of reactive oxygen species level generated by D-Co₃O₄ NPs was higher than that of L-Co₃O₄ NPs. Overall, the synthesized D-Co₃O₄ NPs have the potential to become a kind of novel antibacterial nanomaterials.

关键词: Chiral material, Antibacterial property, Co₃O₄, Antimicrobial resistance

Abstract: With the global spread of antimicrobial resistance, it is imperative to satisfy the need to develop novel antibacterial agents. Here, we synthesized chiral Co₃O₄ nanoparticles (NPs) with obvious bactericidal effects. It was found that the circular dichroism (CD) spectra of L-Co₃O₄ NPs and D-Co₃O₄ NPs exhibited perfect mirror image inversion. Specifically, the survival rate of primary uterine fibroblast (PCS) cells reached above 90% by co-culturing with chiral Co₃O₄ NPs. Besides, the chiral Co₃O₄ NPs showed obvious killing ability on Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli O157:H7) bacteria both in vitro and in vivo. Particularly, D-Co₃O₄ NPs showed better antibacterial activity. Mechanistic studies confirmed that the level of reactive oxygen species level generated by D-Co₃O₄ NPs was higher than that of L-Co₃O₄ NPs. Overall, the synthesized D-Co₃O₄ NPs have the potential to become a kind of novel antibacterial nanomaterials.

Key words: Chiral material, Antibacterial property, Co₃O₄, Antimicrobial resistance

SUN Jia, SONG Shanshan, GUO Caoyu, LIU Liqiang, SUN Maozhong, KUANG Hua, XU Chuanlai, GUO Lingling. Differential Antibacterial Effects of Chiral Co₃O₄[J]. 高等学校化学研究, 2024, 40(6): 1134-1140.

SUN Jia, SONG Shanshan, GUO Caoyu, LIU Liqiang, SUN Maozhong, KUANG Hua, XU Chuanlai, GUO Lingling. Differential Antibacterial Effects of Chiral Co₃O₄[J]. Chemical Research in Chinese Universities, 2024, 40(6): 1134-1140.

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Differential Antibacterial Effects of Chiral Co₃O₄

Differential Antibacterial Effects of Chiral Co₃O₄

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