A Cyanine-based Liposomal Nanophotosensitizer for Enhanced Cancer Chemo-Photodynamic Therapy

doi:10.1007/s40242-021-1186-3

高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (4): 925-933.doi: 10.1007/s40242-021-1186-3

A Cyanine-based Liposomal Nanophotosensitizer for Enhanced Cancer Chemo-Photodynamic Therapy

LI Mengqi¹, MA He¹, SHI Chao¹, ZHANG Han¹, LONG Saran^1,2, SUN Wen^1,2, DU Jianjun^1,2, FAN Jiangli^1,2, PENG Xiaojun^1,2

1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. China;
2. State Key Laboratory of Fine Chemicals, Shenzhen Research Institute, Dalian University of Technology, Shenzhen 518057, P. R, China

收稿日期:2021-04-26 修回日期:2021-05-31 出版日期:2021-08-01 发布日期:2021-07-27
通讯作者: PENG Xiaojun E-mail:pengxj@dlut.edu.cn
基金资助:
This work was supported by the National Natural Science Foundation of China (No.22090011) and the National Natural Science Foundation of China-Liaoning United Fund(No.U1908202).

A Cyanine-based Liposomal Nanophotosensitizer for Enhanced Cancer Chemo-Photodynamic Therapy

LI Mengqi¹, MA He¹, SHI Chao¹, ZHANG Han¹, LONG Saran^1,2, SUN Wen^1,2, DU Jianjun^1,2, FAN Jiangli^1,2, PENG Xiaojun^1,2

1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. China;
2. State Key Laboratory of Fine Chemicals, Shenzhen Research Institute, Dalian University of Technology, Shenzhen 518057, P. R, China

Received:2021-04-26 Revised:2021-05-31 Online:2021-08-01 Published:2021-07-27
Contact: PENG Xiaojun E-mail:pengxj@dlut.edu.cn
Supported by:
This work was supported by the National Natural Science Foundation of China (No.22090011) and the National Natural Science Foundation of China-Liaoning United Fund(No.U1908202).

摘要/Abstract

摘要： Currently, chemotherapy is one of the most important treatment modalities for malignant tumors in the clinic, however, it exhibits some shortcomings, such as poor selectivity, limited efficacy and serious adverse effects. Therefore, synergistic therapy and accurate drug delivery at tumor sites become a promising strategy for achieving tumor eradication. Herein, a smart NIR fluorescence imaging-guided nanoliposome was fabricated by encapsulating a chemotherapeutic drug(doxorubicin, DOX), liposomes(L) and a near-infrared(NIR) photosensitizer(CY) to form L@CY@DOX, which could realize enhanced therapeutic efficacy of chemo-PDT in cancer therapy(PDT=photodynamic therapy). L@CY@DOX can induce mitochondrial apoptosis and produce severe toxicity at the cellular level, and L@CY@DOX can enrich in the tumor site, which significantly induces tumor death. In vitro and in vivo studies demonstrated that L@CY@DOX exhibited great antitumor efficacy compared with each one of these monotherapies, indicating that the combination of chemotherapy and PDT possessed potential development prospects and is anticipated in clinical application.

关键词: Photodynamic therapy, Liposome, Photosensitizer, Cyanine dye, Doxorubicin, Cancer

Abstract: Currently, chemotherapy is one of the most important treatment modalities for malignant tumors in the clinic, however, it exhibits some shortcomings, such as poor selectivity, limited efficacy and serious adverse effects. Therefore, synergistic therapy and accurate drug delivery at tumor sites become a promising strategy for achieving tumor eradication. Herein, a smart NIR fluorescence imaging-guided nanoliposome was fabricated by encapsulating a chemotherapeutic drug(doxorubicin, DOX), liposomes(L) and a near-infrared(NIR) photosensitizer(CY) to form L@CY@DOX, which could realize enhanced therapeutic efficacy of chemo-PDT in cancer therapy(PDT=photodynamic therapy). L@CY@DOX can induce mitochondrial apoptosis and produce severe toxicity at the cellular level, and L@CY@DOX can enrich in the tumor site, which significantly induces tumor death. In vitro and in vivo studies demonstrated that L@CY@DOX exhibited great antitumor efficacy compared with each one of these monotherapies, indicating that the combination of chemotherapy and PDT possessed potential development prospects and is anticipated in clinical application.

Key words: Photodynamic therapy, Liposome, Photosensitizer, Cyanine dye, Doxorubicin, Cancer

LI Mengqi, MA He, SHI Chao, ZHANG Han, LONG Saran, SUN Wen, DU Jianjun, FAN Jiangli, PENG Xiaojun. A Cyanine-based Liposomal Nanophotosensitizer for Enhanced Cancer Chemo-Photodynamic Therapy[J]. 高等学校化学研究, 2021, 37(4): 925-933.

参考文献

[1] Torre L. A., Bray F., Siegel R. L., Ferlay J., Lortet-Tieulent J., Jemal A., CA:A Cancer Journal for Clinicians, 2015, 65, 87
[2] Chen W., Zheng R., Baade P. D., Zhang S., Zeng H., Bray F., Jemal A., Yu X. Q., He J., CA:A Cancer Journal for Clinicians, 2016, 66, 115
[3] Bailly C., Chemical Reviews, 2012, 112, 3611
[4] Jiang C., Cheng H., Yuan A., Tang X., Wu J., Hu Y., Acta Biomaterialia, 2015, 14, 61
[5] Papanikolaou M., Tsianou Z., Skellett A. M., Murphy J., Millington G. W. M., Clinical and Experimental Dermatology, 2018, 43, 506
[6] Li X., Lovell J. F., Yoon J., Chen X., Nature Reviews Clinical Oncology, 2020, 17, 657
[7] Zhang P., Steelant W., Kumar M., Scholfield M., Journal of the American Chemical Society, 2007, 129, 4526
[8] Celli J. P., Spring B. Q., Rizvi I., Evans C. L., Samkoe K. S., Verma S., Pogue B. W., Hasan T., Chemical Reviews, 2010, 110, 2795
[9] Liu K., Liu X., Zeng Q., Zhang Y., Tu L., Liu T., Kong X., Wang Y., Cao F., Lambrechts S. A. G., Aalders M. C. G., Zhang H., ACS Nano, 2012, 6, 4054
[10] Brown S. B., Brown E. A., Walker I., The Lancet Oncology, 2004, 5, 497
[11] Yuan A., Tang X., Qiu X., Jiang K., Wu J., Hu Y., Chemical Communications, 2015, 51, 3340
[12] Xu J., Xu L., Wang C., Yang R., Zhuang Q., Han X., Dong Z., Zhu W., Peng R., Liu Z., ACS Nano, 2017, 11, 4463
[13] Huang L., Li Z., Zhao Y., Zhang Y., Wu S., Zhao J., Han G., Journal of the American Chemical Society, 2016, 138, 14586
[14] Prabhakar U., Maeda H., Jain R. K., Sevick-Muraca E. M., Zamboni W., Farokhzad O. C., Barry S. T., Gabizon A., Grodzinski P., Blakey D. C., Cancer Research, 2013, 73, 2412
[15] Al-Jamal W. T., Kostarelos K., Accounts of Chemical Research, 2011, 44, 1094
[16] Deshpande P. P., Biswas S., Torchilin V. P., Nanomedicine, 2013, 8, 1509
[17] Teo B. M., Hosta-Rigau L., Lynge M. E., Städler B., Nanoscale, 2014, 6, 6426
[18] Sharma A., Sharma U. S., International Journal of Pharmacecetics, 1997, 154, 123
[19] Yang Y., Wang L., Cao H., Li Q., Li Y., Han M., Wang H., Li J., Nano Letters, 2019, 19, 1821
[20] Weijer R., Broekgaarden M., Kos M., van Vught R., Rauws E. A. J., Breukink E., van Gulik T. M., Storm G., Heger M., Journal of Photochemistry and Photobiology C:Photochemistry Reviews, 2015, 23, 103
[21] Dias L. M., Sharifi F., de Keijzer M. J., Mesquita B., Desclos E., Kochan J. A., de Klerk D. J., Ernst D., de Haan L. R., Franchi L. P., van Wijk A. C., Scutigliani E. M., Cavaco J. E. B., Tedesco A. C., Huang X., Pan W., Ding B., Krawczyk P. M., Heger M., Journal of Photochemistry and Photobiology B:Biology, 2021, 216, 112146
[22] Wierzchowski M., Sobotta L., Skupin-Mrugalska P., Kruk J., Jusiak W., Yee M., Konopka K., Düzgüneş N., Tykarska E., Gdaniec M., Mielcarek J., Goslinski T., Journal of Inorganic Biochemistry, 2013, 127, 62
[23] Shi C., Li M., Zhang Z., Yan Q., Peng X., Biomaterials, 2020, 233, 119755
[24] Davis M. E., Chen Z., Shin D. M., Nature Reviews Drug Discovery, 2008, 7, 771

A Cyanine-based Liposomal Nanophotosensitizer for Enhanced Cancer Chemo-Photodynamic Therapy

A Cyanine-based Liposomal Nanophotosensitizer for Enhanced Cancer Chemo-Photodynamic Therapy

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