In situ Activatable Peptide-based Nanoprobes for Tumor Imaging

doi:10.1007/s40242-021-1181-8

摘要/Abstract

摘要： Owing to its excellent biological properties, peptide has been widely used in the design of nanoprobes capable of enhancing tumor imaging signals. In recent years, a number of peptide-based nanoprobes with strong loading capacity and great biocompatibility have been developed for precision tumor imaging by coupling peptide motifs with different imaging agents. It is worth noting that, compared with "always on" mode, the use of stimulus-mediated in situ activatable mode to design and control the self-assembly or nanostructure transformation of peptide-based nanoprobes in vivo can achieve the significant improvement of imaging efficiency. Herein, we summarize the recent progress of in situ activatable peptide-based nanoprobes for tumor imaging in diverse imaging modes, including magnetic resonance imaging(MRI), fluorescence imaging(FI), photoacoustic imaging(PAI), radionuclide imaging(RI) and multimodal imaging. Finally, we briefly prospect the challenges and potential development directions of this field.

关键词: Tumor imaging, Peptide-based nanoprobe, In situ activatable, Self-assembly

Abstract: Owing to its excellent biological properties, peptide has been widely used in the design of nanoprobes capable of enhancing tumor imaging signals. In recent years, a number of peptide-based nanoprobes with strong loading capacity and great biocompatibility have been developed for precision tumor imaging by coupling peptide motifs with different imaging agents. It is worth noting that, compared with "always on" mode, the use of stimulus-mediated in situ activatable mode to design and control the self-assembly or nanostructure transformation of peptide-based nanoprobes in vivo can achieve the significant improvement of imaging efficiency. Herein, we summarize the recent progress of in situ activatable peptide-based nanoprobes for tumor imaging in diverse imaging modes, including magnetic resonance imaging(MRI), fluorescence imaging(FI), photoacoustic imaging(PAI), radionuclide imaging(RI) and multimodal imaging. Finally, we briefly prospect the challenges and potential development directions of this field.

Key words: Tumor imaging, Peptide-based nanoprobe, In situ activatable, Self-assembly

LIU Zhiyu, LIANG Gaolin, ZHAN Wenjun. In situ Activatable Peptide-based Nanoprobes for Tumor Imaging[J]. 高等学校化学研究, 2021, 37(4): 889-899.

LIU Zhiyu, LIANG Gaolin, ZHAN Wenjun. In situ Activatable Peptide-based Nanoprobes for Tumor Imaging[J]. Chemical Research in Chinese Universities, 2021, 37(4): 889-899.

参考文献

[1] Weissleder R., Pittet M. J., Nature, 2008, 452, 580
[2] Wang Y., Zhou K., Huang G., Hensley C., Huang X., Ma X., Zhao T., Sumer B. D., Deberardinis R. J., Gao J., Nat. Mater., 2014, 13, 204
[3] Chen Q., Liu X., Chen J., Zeng J., Cheng Z., Liu Z., Adv. Mater., 2015, 27, 6820
[4] Huang X., Song J., Yung B. C., Huang X., Xiong Y., Chen X., Chem. Soc. Rev., 2018, 47, 2873
[5] Song Z., Mao D., Sung S. H. P., Kwok R. T. K., Lam J. W. Y., Kong D., Ding D., Tang B. Z., Adv. Mater., 2016, 28, 7249
[6] Li P., Liu L., Xiao H., Zhang W., Wang L., Tang B., J. Am. Chem. Soc., 2016, 138, 2893
[7] Xu J., Fang L., Shi M., Huang Y., Yao L., Zhao S., Zhang L., Liang H., Chem. Commun., 2019, 55, 1651
[8] Hartgerink J. D., Beniash E., Stupp S. I., Science, 2001, 294, 1684
[9] Cavalli S., Albericio F., Kros A., Chem. Soc. Rev., 2010, 39, 241
[10] Dehsorkhi A., Castelletto V., Hamley I. W., J. Pept. Sci., 2014, 20, 453
[11] Paramonov S. E., Jun H.-W., Hartgerink J. D., J. Am. Chem. Soc., 2006, 128, 7291
[12] Percec V., Dulcey A. E., Balagurusamy V. S. K., Miura Y., Smidrkal J., Peterca M., Nummelin S., Edlund U., Hudson S. D., Heiney P. A., Duan H., Magonov S. N., Vinogradov S. A., Nature, 2004, 430, 764
[13] Fleming S., Ulijn R. V., Chem. Soc. Rev., 2014, 43, 8150
[14] Tatko C. D., Waters M. L., J. Am. Chem. Soc., 2002, 124, 9372
[15] Waters M. L., Biopolymers, 2004, 76, 435
[16] Andrew Mackay J., Chen M., McDaniel J. R., Liu W., Simnick A. J., Chilkoti A., Nat. Mater., 2009, 8, 993
[17] Deming T. J., Prog. Polym. Sci., 2007, 32, 858
[18] Chandler D., Nature, 2005, 437, 640
[19] Sánchez-Iglesias A., Grzelczak M., Altantzis T., Goris B., Pérez-Juste J., Bals S., Van Tendeloo G., Donaldson S. H., Chmelka B. F., Israelachvili J. N., Liz-Marzán L. M., ACS Nano, 2012, 6, 11059
[20] Caplan M. R., Moore P. N., Zhang S., Kamm R. D., Lauffenburger D. A., Biomacromolecules, 2000, 1, 627
[21] Kalsin A. M., Fialkowski M., Paszewski M., Smoukov S. K., Bishop K. J. M., Grzybowski B. A., Science, 2006, 312, 420
[22] Niece K. L., Hartgerink J. D., Donners J. J. J. M., Stupp S. I., J. Am. Chem. Soc., 2003, 125, 7146
[23] Sherrington D. C., Taskinen K. A., Chem. Soc. Rev., 2001, 30, 83
[24] Au-Yeung H.-L., Leung S. Y.-L., Tam A. Y.-Y., Yam V. W.-W., J. Am. Chem. Soc., 2014, 136, 17910
[25] Ni D., Zhang J., Bu W., Xing H., Han F., Xiao Q., Yao Z., Chen F., He Q., Liu J., Zhang S., Fan W., Zhou L., Peng W., Shi J., ACS Nano, 2014, 8, 1231
[26] Riehemann K., Schneider S. W., Luger T. A., Godin B., Ferrari M., Fuchs H., Angew. Chem. Int. Ed., 2009, 48, 872
[27] Fang H., Li M., Liu Q., Gai Y., Yuan L., Wang S., Zhang X., Ye M., Zhang Y., Gao M., Hou Y., Lan X., Nano-Micro. Lett., 2020, 12, 62
[28] Wang Y., Du W., Zhang T., Zhu Y., Ni Y., Wang C., Sierra Raya F. M., Zou L., Wang L., Liang G., ACS Nano, 2020, 14, 9585
[29] Zhang L., Jing D., Jiang N., Rojalin T., Baehr C. M., Zhang D., Xiao W., Wu Y., Cong Z., Li J. J., Li Y., Wang L., Lam K. S., Nat. Nanotechnol., 2020, 15, 145
[30] Wang H., Zhao Y., An H.-W., Zheng R., Yang J., Mamuti M., Hou D., Angew. Chem. Int. Ed., 2021, 60, 7809
[31] Wang Y., Li X., Chen P., Dong Y., Liang G., Yu Y., Nanoscale, 2020, 12, 1886
[32] Chen K., Conti P. S., Adv. Drug Deliv. Rev., 2010, 62, 1005
[33] Cai W., Shin D.-W., Chen K., Gheysens O., Cao Q., Wang S. X., Gambhir S. S., Chen X., Nano. Lett., 2006, 6, 669
[34] Zhao Y., Ji T., Wang H., Li S., Zhao Y., Nie G., J. Control. Release, 2014, 177, 11
[35] Deng Y., Zhan W., Liang G., Adv. Healthcare Mater., 2021, 10, 2001211
[36] Lyu Y., Pu K., Adv. Sci., 2017, 4, 1600481
[37] Lu Y., Aimetti A. A., Langer R., Gu Z., Nat. Rev. Mater., 2016, 2, 16075
[38] Rosenkrans Z. T., Ferreira C. A., Ni D., Cai W., Adv. Healthc. Mater., 2021, 10, 2000690
[39] Beets-Tan R. G. H., Beets G. L., Vliegen R. F. A., Kessels A. G. H., Boven H. V., Bruine A. D., von Meyenfeldt M. F., Baeten C., van Engelshoven J. M. A., Lancet, 2001, 357, 497
[40] Day S. E., Kettunen M. I., Gallagher F. A., Hu D.-E., Lerche M., Wolber J., Golman K., Ardenkjaer-Larsen J. H., Brindle K. M., Nat. Med., 2007, 13, 1382
[41] Caravan P., Chem. Soc. Rev., 2006, 35, 512
[42] Lee N., Hyeon T., Chem. Soc. Rev., 2012, 41, 2575
[43] Na H. B., Song I. C., Hyeon T., Adv. Mater., 2009, 21, 2133
[44] Liang G., Ronald J., Chen Y., Ye D., Pandit P., Ma M. L., Rutt B., Rao J., Angew. Chem. Int. Ed., 2011, 50, 6283
[45] Zhang J., Mu Y.-L., Ma Z.-Y., Han K., Han H.-Y., Biomaterials, 2018, 182, 269
[46] Dong L., Qian J., Hai Z., Xu J., Du W., Zhong K., Liang G., Anal. Chem., 2017, 89, 6922
[47] Zheng Z., Sun H., Hu C., Li G., Liu X., Chen P., Cui Y., Liu J., Wang J., Liang G., Anal. Chem., 2016, 88, 3363
[48] Kenry, Duan Y., Liu B., Adv. Mater., 2018, 30, 1802394
[49] Li Y., Zhong H., Huang Y., Zhao R., Molecules, 2019, 24, 4593
[50] Huang M., Yu R., Xu K., Ye S., Kuang S., Zhu X., Wan Y., Chem. Sci., 2016, 7, 4485
[51] Zhou J., Du X., Berciu C., He H., Shi J., Nicastro D., Xu B., Chem, 2016, 1, 246
[52] He H., Wang J., Wang H., Zhou N., Yang D., Green D. R., Xu B., J. Am. Chem. Soc., 2018, 140, 1215
[53] Yang L., Peltier R., Zhang M., Song D., Huang H., Chen G., Chen Y., Zhou F., Hao Q., Bian L., He M.-l., Wang Z., Hu Y., Sun H., J. Am. Chem. Soc., 2020, 142, 18150
[54] Wang Y., Zhan J., Chen Y., Ai S., Li L., Wang L., Shi Y., Zheng J., Yang Z., Nanoscale, 2019, 11, 13714
[55] Hao Y., Xu S., Chen M., Qian J., Tang B., Chem. Res. Chinese Universities, 2021, 37(1), 25
[56] Yang L., Guo L., Yu H., Wang G., Sun J., Zhang P., Gu X., Tang B., Chem. Res. Chinese Universities, 2021, 37(1), 129
[57] Zhan F.-K., Liu J.-C., Cheng B., Liu Y.-C., Lai T.-S., Lin H.-C., Yeh M.-Y., Chem. Commun., 2019, 55, 1060
[58] Hu X.-X., He P.-P., Qi G.-B., Gao Y.-J., Lin Y.-X., Yang C., Yang P.-P., Hao H., Wang L., Wang H., ACS Nano, 2017, 11, 4086
[59] Wang L., Lv Y., Li C., Yang G., Fu B., Peng Q., Jian L., Hou D., Wang J., Zhao C., Yang P., Zhang K., Wang L., Wang Z., Wang H., Xu W., Small, 2020, 16, 2004548
[60] Lin Y.-X., Qiao S.-L., Wang Y., Zhang R.-X., An H.-W., Ma Y., Rajapaksha R. Y. J., Qiao Z.-Y., Wang L., Wang H., ACS Nano, 2017, 11, 1826
[61] Hong G., Antaris A. L., Dai H., Nat. Biomed. Eng, 2017, 1, 0010
[62] Wu L., Ishigaki Y., Hu Y., Sugimoto K., Zeng W., Harimoto T., Sun Y., He J., Suzuki T., Jiang X., Chen H.-Y., Ye D., Nat. Commun., 2020, 11, 446
[63] Luo Z., Huang Z., Li K., Sun Y., Lin J., Ye D., Chen H.-Y., Anal. Chem., 2018, 90, 2875
[64] Zhao X.-X., Li L.-L., Zhao Y., An H.-W., Cai Q., Lang J.-Y., Han X.-X., Peng B., Fei Y., Liu H., Qin H., Nie G., Wang H., Angew. Chem. Int. Ed., 2019, 58, 15287
[65] An H.-W., Li L.-L., Wang Y., Wang Z., Hou D., Lin Y.-X., Qiao S.-L., Wang M.-D., Yang C., Cong Y., Ma Y., Zhao X.-X., Cai Q., Chen W.-T., Lu C.-Q., Xu W., Wang H., Zhao Y., Nat. Commun., 2019, 10, 4861
[66] Liu F.-H., Cong Y., Qi G.-B., Ji L., Qiao Z.-Y., Wang H., Nano Lett., 2018, 18, 6577
[67] Cheng D.-B., Zhang X.-H., Chen Y., Chen H., Qiao Z.-Y., Wang H., iScience, 2020, 23, 101144
[68] Chen S., Liu J., Li Y., Wu X., Yuan Q., Yang R., Zheng J., TrAC, Trends Anal. Chem., 2020, 131, 116010
[69] Liu J.-N., Bu W., Shi J., Chem. Rev., 2017, 117, 6160
[70] Huang C., Zheng J., Ma D., Liu N., Zhu C., Li J., Yang R., J. Mat. Chem. B, 2018, 6, 6424
[71] Xu C., Zou H., Zhao Z., Zhang P., Kwok R. T. K., Lam J. W. Y., Sung H. H. Y., Williams I. D., Tang B. Z., Adv. Funct. Mater., 2019, 29, 1903278
[72] Zhang Z., Wang R., Huang X., Zhu W., He Y., Liu W., Liu F., Feng F., Qu W., Anal. Chem., 2021, 93, 1627
[73] Li L.-L., Qiao S.-L., Liu W.-J., Ma Y., Wan D., Pan J., Wang H., Nat. Commun., 2017, 8, 1276
[74] Peng B., Zhao X., Yang M. S., Li L. L., J. Mat. Chem. B, 2019, 7, 5626
[75] Li J., Shi K., Sabet Z. F., Fu W., Zhou H., Xu S., Liu T., You M., Cao M., Xu M., Cui X., Hu B., Liu Y., Chen C., Sci. Adv., 2019, 5, eaax0937
[76] Fan Y., Lu M., Yu X.-A., He M., Zhang Y., Ma X.-N., Kou J., Yu B.-Y., Tian J., Anal. Chem., 2019, 91, 6585
[77] Wang L. V., Hu S., Science, 2012, 335, 1458
[78] Chen G., Roy I., Yang C., Prasad P. N., Chem. Rev., 2016, 116, 2826
[79] Zhang D., Qi G. B., Zhao Y. X., Qiao S. L., Yang C., Wang H., Adv. Mater., 2015, 27, 6078
[80] Wang Y., Hu X., Weng J., Li J., Fan Q., Zhang Y., Ye D., Angew. Chem. Int. Ed., 2019, 131, 4940
[81] Huang P., Gao Y., Lin J., Hu H., Liao H.-S., Yan X., Tang Y., Jin A., Song J., Niu G., Zhang G., Horkay F., Chen X., ACS Nano, 2015, 9, 9517
[82] Wu C., Zhang R., Du W., Cheng L., Liang G., Nano Lett., 2018, 18, 7749
[83] Baum R. P., Kulkarni H. R., Theranostics, 2012, 2, 437
[84] Zhou M., Zhang R., Huang M., Lu W., Song S., Melancon M. P., Tian M., Liang D., Li C., J. Am. Chem. Soc., 2010, 132, 15351
[85] Simone E. A., Zern B. J., Chacko A.-M., Mikitsh J. L., Blankemeyer E. R., Muro S., Stan R. V., Muzykantov V. R., Biomaterials, 2012, 33, 5406
[86] Preshlock S., Tredwell M., Gouverneur V., Chem. Rev., 2016, 116, 719
[87] Kratochwil C., Flechsig P., Lindner T., Abderrahim L., Altmann A., Mier W., Adeberg S., Rathke H., Röhrich M., Winter H., Plinkert P. K., Marme F., Lang M., Kauczor H.-U., Jäger D., Debus J., Haberkorn U., Giesel F. L., J. Nucl. Med., 2019, 60, 801
[88] Bensch F., Van Der Veen E. L., Lub-De Hooge M. N., Jorritsma-Smit A., Boellaard R., Kok I. C., Oosting S. F., Schröder C. P., Hiltermann T. J. N., Van Der Wekken A. J., Groen H. J. M., Kwee T. C., Elias S. G., Gietema J. A., Bohorquez S. S., De Crespigny A., Williams S.-P., Mancao C., Brouwers A. H., Fine B. M., De Vries E. G. E., Nat. Med., 2018, 24, 1852
[89] Ardakani J. B., Akhlaghi M., Nikkholgh B., Hosseinimehr S. J., Bioorg. Chem., 2021, 106, 104474
[90] Carlomagno N., Incollingo P., Tammaro V., Peluso G., Rupealta N., Chiacchio G., Sandoval Sotelo M. L., Minieri G., Pisani A., Riccio E., Biomed Res. Int., 2017, 2017, 7869802
[91] Wang H., Chen P., Wu H., Zou P., Wu J., Liu Y., Liang G., Anal. Chem., 2019, 91, 14842
[92] Shen B., Jeon J., Palner M., Ye D., Shuhendler A., Chin F. T., Rao J., Angew. Chem. Int. Ed., 2013, 52, 10511
[93] Palner M., Shen B., Jeon J., Lin J., Chin F. T., Rao J., J. Nucl. Med., 2015, 56, 1415
[94] Chen Z., Chen M., Zhou K., Rao J., Angew. Chem. Int. Ed., 2020, 132, 7938
[95] Hussain T., Nguyen Q. T., Adv. Drug Deliv. Rev., 2014, 66, 90
[96] Louie A., Chem. Rev., 2010, 110, 3146
[97] Lee H.-Y., Li Z., Chen K., Hsu A. R., Xu C., Xie J., Sun S., Chen X., J. Nucl. Med., 2008, 49, 1371
[98] Zhang D., Qi G.-B., Zhao Y.-X., Qiao S.-L., Yang C., Wang H., Adv. Mater., 2015, 27, 6125
[99] Lee J., Lee T. S., Ryu J., Hong S., Kang M., Im K., Kang J. H., Lim S. M., Park S., Song R., J. Nucl. Med., 2013, 54, 96
[100] de Jong M., Breeman W. A. P., Kwekkeboom D. J., Valkema R., Krenning E. P., Acc. Chem. Res., 2009, 42, 873
[101] Lee S., Xie J., Chen X., Chem. Rev., 2010, 110, 3087
[102] Zhang P., Cui Y., Anderson C. F., Zhang C., Li Y., Wang R., Cui H., Chem. Soc. Rev., 2018, 47, 3490
[103] Wang W., Ma Z., Zhu S., Wan H., Yue J., Ma H., Ma R., Yang Q., Wang Z., Li Q., Qian Y., Yue C., Wang Y., Fan L., Zhong Y., Zhou Y., Gao H., Ruan J., Hu Z., Liang Y., Dai H., Adv. Mater., 2018, 30, 1800106
[104] Cheng Y., Meyers J. D., Agnes R. S., Doane T. L., Kenney M. E., Broome A.-M., Burda C., Basilion J. P., Small, 2011, 7, 2301
[105] Kumar S. R., Gallazzi F. A., Ferdani R., Anderson C. J., Quinn T. P., Deutscher S. L., Cancer Biother. Radiopharm., 2010, 25, 693
[106] Lemaster J. E., Wang Z., Hariri A., Chen F., Hu Z., Huang Y., Barback C. V., Cochran R., Gianneschi N. C., Jokerst J. V., Chem. Mat., 2018, 31, 251
[107] Zhao Z., Fan H., Zhou G., Bai H., Liang H., Wang R., Zhang X., Tan W., J. Am. Chem. Soc., 2014, 136, 11220
[108] Sowers M. A., McCombs J. R., Wang Y., Paletta J. T., Morton S. W., Dreaden E. C., Boska M. D., Ottaviani M. F., Hammond P. T., Rajca A., Nat. Commun., 2014, 5, 1
[109] Shi H., Sun Y., Yan R., Liu S., Zhu L., Liu S., Feng Y., Wang P., He J., Zhou Z., Ye D., Nano Lett., 2019, 19, 937
[110] An R., Cheng X., Wei S., Hu Y., Sun Y., Huang Z., Chen H. Y., Ye D., Angew. Chem. Int. Ed., 2020, 132, 20817
[111] Gao H., Chu C., Cheng Y., Zhang Y., Pang X., Li D., Wang X., Ren E., Xie F., Bai Y., Chen L., Liu G., Wang M., ACS Appl. Mater. Interfaces, 2020, 12, 26880
[112] Yin L., Sun H., Zhang H., He L., Qiu L., Lin J., Xia H., Zhang Y., Ji S., Shi H., Gao M., J. Am. Chem. Soc., 2019, 141, 3265
[113] Zhang Y., Chang J., Huang F., Yang L., Ren C., Ma L., Zhang W., Dong H., Liu J., Liu J., ACS Biomater. Sci. Eng., 2019, 5, 1589