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高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (3): 621-622.doi: 10.1007/s40242-021-1210-7

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Tumor-discriminating Nanoceria Antioxidant Enables Protection Against Acute Kidney Injury Without Compromising Chemotherapeutic Effects

WANG Jing, NIE Guangjun, ZHAO Yuliang   

  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
  • 收稿日期:2021-05-08 修回日期:2021-05-09 出版日期:2021-06-01 发布日期:2021-05-13
  • 通讯作者: NIE Guangjun, ZHAO Yuliang E-mail:niegj@nanoctr.cn;zhaoyl@nanoctr.cn
  • 基金资助:
    This work was supported by the National Basic Research Program of China(No. 2018YFA0208900) and the National Key R&D Program of China(No. 2018YFE0205300).

Tumor-discriminating Nanoceria Antioxidant Enables Protection Against Acute Kidney Injury Without Compromising Chemotherapeutic Effects

WANG Jing, NIE Guangjun, ZHAO Yuliang   

  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
  • Received:2021-05-08 Revised:2021-05-09 Online:2021-06-01 Published:2021-05-13
  • Contact: NIE Guangjun, ZHAO Yuliang E-mail:niegj@nanoctr.cn;zhaoyl@nanoctr.cn
  • Supported by:
    This work was supported by the National Basic Research Program of China(No. 2018YFA0208900) and the National Key R&D Program of China(No. 2018YFE0205300).

摘要： Acute kidney injury is one of the most troublesome and lethal adverse effects in patients receiving chemotherapy. Conventional approaches that mitigate the toxicity of chemotherapeutic agents, however, also consequently compromise their tumor-killing efficacy. In order to overcome this dilemma, Ling and colleagues developed a ceria nanoparticle-based antioxidant agent that selectively relieved chemotherapy-induced oxidative damage in healthy tissues but not in the tumor microenvironment, where the slightly acidic pH acted to inhibit its enzyme-like and antioxidant activity. These ceria nanoparticles with context-dependent catalytic activity thus implied a possible reconciliation between effective protection from kidney injury and high potency of chemotherapy. The corresponding research has been published in Nature Communications and can be accessed at https://doi.org/10.1038/s41467-021-21714-2.

Abstract: Acute kidney injury is one of the most troublesome and lethal adverse effects in patients receiving chemotherapy. Conventional approaches that mitigate the toxicity of chemotherapeutic agents, however, also consequently compromise their tumor-killing efficacy. In order to overcome this dilemma, Ling and colleagues developed a ceria nanoparticle-based antioxidant agent that selectively relieved chemotherapy-induced oxidative damage in healthy tissues but not in the tumor microenvironment, where the slightly acidic pH acted to inhibit its enzyme-like and antioxidant activity. These ceria nanoparticles with context-dependent catalytic activity thus implied a possible reconciliation between effective protection from kidney injury and high potency of chemotherapy. The corresponding research has been published in Nature Communications and can be accessed at https://doi.org/10.1038/s41467-021-21714-2.