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高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (3): 619-620.doi: 10.1007/s40242-021-1208-1

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Host-Guest Sensor Array for Discriminating G-Quadruplexes

HU Xinyue, GUO Dongsheng   

  1. College of Chemistry, Key Laboratory of Functional Polymer Materials(Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China
  • 收稿日期:2021-05-08 修回日期:2021-05-09 出版日期:2021-06-01 发布日期:2021-05-31
  • 通讯作者: GUO Dongsheng E-mail:dshguo@nankai.edu.cn

Host-Guest Sensor Array for Discriminating G-Quadruplexes

HU Xinyue, GUO Dongsheng   

  1. College of Chemistry, Key Laboratory of Functional Polymer Materials(Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China
  • Received:2021-05-08 Revised:2021-05-09 Online:2021-06-01 Published:2021-05-31
  • Contact: GUO Dongsheng E-mail:dshguo@nankai.edu.cn

摘要： Rapid classification of the secondary structures of nucleic acids, such as G-quadruplexes(G4s) is desirable but very challenging due to the high similarity among different folding. Chen et al. constructed a host-guest sensor array to differentiate the topology of unmodified G4s for the first time. Multiple equilibria present in the sensing system resulted in differential fluorescence responses to different G4 structures, and yielded excellent selec-tivity of the sensor array in structure discrimination. The corresponding research has been published in Nature Chemistry and can be accessed at https://doi.org/10.1038/s41557-021-00647-9.

Abstract: Rapid classification of the secondary structures of nucleic acids, such as G-quadruplexes(G4s) is desirable but very challenging due to the high similarity among different folding. Chen et al. constructed a host-guest sensor array to differentiate the topology of unmodified G4s for the first time. Multiple equilibria present in the sensing system resulted in differential fluorescence responses to different G4 structures, and yielded excellent selec-tivity of the sensor array in structure discrimination. The corresponding research has been published in Nature Chemistry and can be accessed at https://doi.org/10.1038/s41557-021-00647-9.