高等学校化学研究 ›› 2012, Vol. 28 ›› Issue (6): 1003-1010.
Chiral Diamine-catalyzed Asymmetric Aldol Reaction
LI Hui, XU Da-zhen, WU Lu-lu, WANG Yong-mei
- State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China
Chiral Diamine-catalyzed Asymmetric Aldol Reaction
LI Hui, XU Da-zhen, WU Lu-lu, WANG Yong-mei
- State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China
摘要：
A highly efficient catalytic system composed of a simple and commercially available chiral primary diamine (1R,2R)-cyclohexane-1,2-diamine(6) and trifluoroacetic acid (TFA) was employed for asymmetric Aldol reaction in em-PrOH at room temperature. A loading of 10%(molar fraction) catalyst 6 with TFA as a cocatalyst could catalyze the Aldol reactions of various ketones or aldehydes with a series of aromatic aldehydes, furnishing Aldol pro- ducts in moderate to high yields(up to >99%) with enantioselectivities of up to >99% and diastereoselectivities of up to 99:1.