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高等学校化学研究 ›› 2012, Vol. 28 ›› Issue (4): 647-651.

• Articles • 上一篇    下一篇

Novel Bis-β-diketone-type Ligand and Its Copper and Zinc Complexes for Two-photon Biological Imaging

ZHOU Shuang-sheng, XUE Xuan, WEI Dong, JIANG Bo, WANG Jia-feng, LU Cheng-hua   

  1. Anhui Engineering Research Center of Modernized Chinese Medicine, Department of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230031, P. R. China
  • 收稿日期:2011-08-23 修回日期:2011-11-03 出版日期:2012-07-25 发布日期:2012-07-25
  • 通讯作者: ZHOU Shuang-sheng E-mail:zshuangsheng@126.com
  • 基金资助:

    Supported by the National Natural Science Foundation of China(No.21071001), the Project of the Department of Education Committee of Anhui Province, China(No.KJ2010A222), the Natural Science Foundation of Anhui Unversity of Traditional Chinese Medicine, China(No.2011zr005A) and the Natural Science Foundation of Anhui Province, China(No.1208085MH273).

Novel Bis-β-diketone-type Ligand and Its Copper and Zinc Complexes for Two-photon Biological Imaging

ZHOU Shuang-sheng, XUE Xuan, WEI Dong, JIANG Bo, WANG Jia-feng, LU Cheng-hua   

  1. Anhui Engineering Research Center of Modernized Chinese Medicine, Department of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230031, P. R. China
  • Received:2011-08-23 Revised:2011-11-03 Online:2012-07-25 Published:2012-07-25
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.21071001), the Project of the Department of Education Committee of Anhui Province, China(No.KJ2010A222), the Natural Science Foundation of Anhui Unversity of Traditional Chinese Medicine, China(No.2011zr005A) and the Natural Science Foundation of Anhui Province, China(No.1208085MH273).

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摘要： A curcumin derivative ligand, 1,7-bis(3-methoxyl-4-oxyethylacetate)phenyl-1,6-heptadiene-3,5-diketone (diethyl acetatecurcumin, abbreviated as HL), and its Cu(II) and Zn(II) complexes have been synthesized and characterized by elemental analyses, infrared(IR), 1H NMR and molar conductivity. The experimental results show that the resulting complexes bear strong two-photon excited fluorescence(TPEF) in N,N-dimethyformamide solvent, which has been proven to be potentially useful for two-photon microscopy imaging in living cells. In addition, cytotoxicity tests show that the low-micromolar concentrations of metal-ligand complex(ML2) did not cause significant reduction in cell viability over a period of, at least, 24 h and should be safe for further biological studies.

关键词: Diethyl acetatecurcumin, Photophysical property, Cell imaging

Abstract: A curcumin derivative ligand, 1,7-bis(3-methoxyl-4-oxyethylacetate)phenyl-1,6-heptadiene-3,5-diketone (diethyl acetatecurcumin, abbreviated as HL), and its Cu(II) and Zn(II) complexes have been synthesized and characterized by elemental analyses, infrared(IR), 1H NMR and molar conductivity. The experimental results show that the resulting complexes bear strong two-photon excited fluorescence(TPEF) in N,N-dimethyformamide solvent, which has been proven to be potentially useful for two-photon microscopy imaging in living cells. In addition, cytotoxicity tests show that the low-micromolar concentrations of metal-ligand complex(ML2) did not cause significant reduction in cell viability over a period of, at least, 24 h and should be safe for further biological studies.

Key words: Diethyl acetatecurcumin, Photophysical property, Cell imaging