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高等学校化学研究 ›› 2012, Vol. 28 ›› Issue (4): 642-646.

• Articles • 上一篇    下一篇

Ga(ClO4)3-catalyzed Reaction of 1,2-Diamines and α-Bromoketones: Synthesis of 2-Substituted Quinoxalines

JI Yun-fei, CHEN Tang-ming, MAO Hai-feng, ZOU Jian-ping   

  1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Material Science, Soochow University, Suzhou 215123, P. R. China
  • 收稿日期:2011-11-03 修回日期:2011-12-19 出版日期:2012-07-25 发布日期:2012-07-25
  • 通讯作者: ZOU Jian-ping E-mail:jpzou@suda.edu.cn
  • 基金资助:

    Supported by the National Natural Science Foundation of China(Nos.20772088, 21172163) and the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,China(No.JSSYSXK2010007).

Ga(ClO4)3-catalyzed Reaction of 1,2-Diamines and α-Bromoketones: Synthesis of 2-Substituted Quinoxalines

JI Yun-fei, CHEN Tang-ming, MAO Hai-feng, ZOU Jian-ping   

  1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Material Science, Soochow University, Suzhou 215123, P. R. China
  • Received:2011-11-03 Revised:2011-12-19 Online:2012-07-25 Published:2012-07-25
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos.20772088, 21172163) and the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,China(No.JSSYSXK2010007).

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摘要： Ga(ClO4)3-catalyzed reaction of 1,2-aryldiamines and α-bromoketones to afford 2-substituted quinoxa- lines in good yields is described. The reaction proceeded via grinding process with 10%(molar fraction) catalyst under solvent-free conditions at room temperature. For unsymmetrical o-phenylenediamines bearing electron-with- drawing groups, regio-selective quinoxalines were obtained.

关键词: Ga(ClO4)3, 1,2-Aryldiamine, α-Bromoketone, 2-Substituted quinoxaline, Solvent-free reaction

Abstract: Ga(ClO4)3-catalyzed reaction of 1,2-aryldiamines and α-bromoketones to afford 2-substituted quinoxa- lines in good yields is described. The reaction proceeded via grinding process with 10%(molar fraction) catalyst under solvent-free conditions at room temperature. For unsymmetrical o-phenylenediamines bearing electron-with- drawing groups, regio-selective quinoxalines were obtained.

Key words: Ga(ClO4)3, 1,2-Aryldiamine, α-Bromoketone, 2-Substituted quinoxaline, Solvent-free reaction