Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid

高等学校化学研究 ›› 2011, Vol. 27 ›› Issue (3): 524-527.

Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid

LU Jian¹, LIU Jian-guo^1*, SONG Xiao-feng², CHEN Xue-si² and WU Xiao-dong¹

1. The First Hospital of Jilin University, Changchun 130021, P. R. China;
2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

收稿日期:2010-10-08 修回日期:2011-03-28 出版日期:2011-05-25 发布日期:2011-04-29
通讯作者: LIU Jian-guo E-mail:jgliu.2005@yahoo.com.cn

Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid

LU Jian¹, LIU Jian-guo^1*, SONG Xiao-feng², CHEN Xue-si² and WU Xiao-dong¹

1. The First Hospital of Jilin University, Changchun 130021, P. R. China;
2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Received:2010-10-08 Revised:2011-03-28 Online:2011-05-25 Published:2011-04-29
Contact: LIU Jian-guo E-mail:jgliu.2005@yahoo.com.cn

摘要/Abstract

摘要： Novel sandwich structure-like nano?ber multilayered meshes were fabricated via electrospinning. The purpose of the present work was to control zoledronic acid release via the novel structure of sandwich structure-like meshes. The in vitro release experiments reveal that the drug release speed and initial burst release were controllable by adjusting the thicknesses of electrospun barrier mesh and drug-loaded mesh. Compared with those of other drug delivery systems, the main advantages of the sandwich structure-like fiber meshes are facile preparation conditions and the generality for hydrophobic and hydrophilic pharmaceuticals.

关键词: Sandwich structured nanofiber mesh, Zoledronic acid, Drug release, Electrospinning

Abstract: Novel sandwich structure-like nano?ber multilayered meshes were fabricated via electrospinning. The purpose of the present work was to control zoledronic acid release via the novel structure of sandwich structure-like meshes. The in vitro release experiments reveal that the drug release speed and initial burst release were controllable by adjusting the thicknesses of electrospun barrier mesh and drug-loaded mesh. Compared with those of other drug delivery systems, the main advantages of the sandwich structure-like fiber meshes are facile preparation conditions and the generality for hydrophobic and hydrophilic pharmaceuticals.

Key words: Sandwich structured nanofiber mesh, Zoledronic acid, Drug release, Electrospinning

中图分类号:

Q819

LU Jian, LIU Jian-guo*, SONG Xiao-feng, CHEN Xue-si and WU Xiao-dong. Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid[J]. 高等学校化学研究, 2011, 27(3): 524-527.

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Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid

Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid

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