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高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (3): 394-403.doi: 10.1007/s40242-021-1125-3

• Review • 上一篇    下一篇

Electrospinning of Biomaterials for Vascular Regeneration

BAI Shan1, ZHANG Xiangyu1, ZANG Leilei1, YANG Songze1, CHEN Xiaoqi2, YUAN Xiaoyan1   

  1. 1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, P. R. China;
    2. Institute of Energy Resources, Hebei Academy of Sciences, Shijiazhuang 050081, P. R. China
  • 收稿日期:2021-03-15 修回日期:2021-04-24 出版日期:2021-06-01 发布日期:2021-05-31
  • 通讯作者: YUAN Xiaoyan E-mail:yuanxy@tju.edu.cn
  • 基金资助:
    This work was supported by the National Natural Science Foundation of China(No. 52073204).

Electrospinning of Biomaterials for Vascular Regeneration

BAI Shan1, ZHANG Xiangyu1, ZANG Leilei1, YANG Songze1, CHEN Xiaoqi2, YUAN Xiaoyan1   

  1. 1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, P. R. China;
    2. Institute of Energy Resources, Hebei Academy of Sciences, Shijiazhuang 050081, P. R. China
  • Received:2021-03-15 Revised:2021-04-24 Online:2021-06-01 Published:2021-05-31
  • Contact: YUAN Xiaoyan E-mail:yuanxy@tju.edu.cn
  • Supported by:
    This work was supported by the National Natural Science Foundation of China(No. 52073204).

摘要： Cardiovascular diseases have been the leading cause of morbidity and mortality in the world recently. With the growing aging population accompanied by chronic diseases, such as uremia and diabetes, there is an increasing clinical demand for vascular grafts with proper performance. Although some achievements have been made in the development of tissue-engineered vascular grafts composed of natural and synthetic polymeric materials or decellularized vessels, clinical applications with a diameter of less than 6 mm are still principally derived from autografts, such as autologous saphenous veins. Many challenges remain in anti-thrombosis, rapid endothelialization, modulating the inflammatory response and inhibition of intimal hyperplasia and calcification. In the review, recent progress in the electrospinning of biodegradable polymers for vascular regeneration are summarized, especially from the view of biomechanical factors. Hybrid vascular grafts consisting of natural and synthetic polymers with multicomponent, di-or tri-layers are focused in order to provide novel experiences in biomaterials for applications in this field.

关键词: Electrospinning, Biodegradable polymer, Vascular graft, Biomechanical factor, Compliance

Abstract: Cardiovascular diseases have been the leading cause of morbidity and mortality in the world recently. With the growing aging population accompanied by chronic diseases, such as uremia and diabetes, there is an increasing clinical demand for vascular grafts with proper performance. Although some achievements have been made in the development of tissue-engineered vascular grafts composed of natural and synthetic polymeric materials or decellularized vessels, clinical applications with a diameter of less than 6 mm are still principally derived from autografts, such as autologous saphenous veins. Many challenges remain in anti-thrombosis, rapid endothelialization, modulating the inflammatory response and inhibition of intimal hyperplasia and calcification. In the review, recent progress in the electrospinning of biodegradable polymers for vascular regeneration are summarized, especially from the view of biomechanical factors. Hybrid vascular grafts consisting of natural and synthetic polymers with multicomponent, di-or tri-layers are focused in order to provide novel experiences in biomaterials for applications in this field.

Key words: Electrospinning, Biodegradable polymer, Vascular graft, Biomechanical factor, Compliance