Synthesis and Antibacterial Activities of Erythromycin Derivatives

高等学校化学研究 ›› 2005, Vol. 21 ›› Issue (2): 177-182.

Synthesis and Antibacterial Activities of Erythromycin Derivatives

FENG Run-liang, GONG Ping, FANG Lin, HONG Wei

School of Pharmacetical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China

收稿日期:2004-03-31 出版日期:2005-03-24 发布日期:2011-07-27

Synthesis and Antibacterial Activities of Erythromycin Derivatives

FENG Run-liang, GONG Ping, FANG Lin, HONG Wei

School of Pharmacetical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China

Received:2004-03-31 Online:2005-03-24 Published:2011-07-27

摘要/Abstract

摘要： Ten new erythromycin antibacterial agents containing amidino group were designed and synthesized from erythromycin via oximation, reduction and condensation.Their structures were confirmed by MS and ¹³C NMR; the synthetic condition(reaction medium)was explored; and their in vtiro antibacterial activities were tested.Compound HMA-3 showed antibacterial activity against staphylococcus aureus, which is equivalent to that of erythromycin A.Compounds HMA-8 and HMA-4 also showed an antibacterial activitiy.But no compound showed bactericidal activity.

关键词: Erythromycin derivatives, Synthesis, Antibacterial activities

Abstract: Ten new erythromycin antibacterial agents containing amidino group were designed and synthesized from erythromycin via oximation, reduction and condensation.Their structures were confirmed by MS and ¹³C NMR; the synthetic condition(reaction medium)was explored; and their in vtiro antibacterial activities were tested.Compound HMA-3 showed antibacterial activity against staphylococcus aureus, which is equivalent to that of erythromycin A.Compounds HMA-8 and HMA-4 also showed an antibacterial activitiy.But no compound showed bactericidal activity.

Key words: Erythromycin derivatives, Synthesis, Antibacterial activities

FENG Run-liang, GONG Ping, FANG Lin, HONG Wei. Synthesis and Antibacterial Activities of Erythromycin Derivatives[J]. 高等学校化学研究, 2005, 21(2): 177-182.

FENG Run-liang, GONG Ping, FANG Lin, HONG Wei. Synthesis and Antibacterial Activities of Erythromycin Derivatives[J]. Chemical Research in Chinese Universities, 2005, 21(2): 177-182.

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Synthesis and Antibacterial Activities of Erythromycin Derivatives

Synthesis and Antibacterial Activities of Erythromycin Derivatives

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