Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism

高等学校化学研究 ›› 2001, Vol. 17 ›› Issue (1): 69-72.

Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism

LEI Ying-jie, ZHU Chun-hua, WANG Zuo-quan, LIU Hong

Xi'an Modern Chemistry Research Institute, Xi'an 710065, P. R. China

收稿日期:1999-12-22 出版日期:2001-01-24 发布日期:2011-08-04

Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism

LEI Ying-jie, ZHU Chun-hua, WANG Zuo-quan, LIU Hong

Xi'an Modern Chemistry Research Institute, Xi'an 710065, P. R. China

Received:1999-12-22 Online:2001-01-24 Published:2011-08-04

摘要/Abstract

摘要： The improved 3-step preparation of a key antitumor agent, 7-ethyl-10-hydroxycamptothecin(SN-38), which consists of ethylation, oxidation and photo-chemical rearrangement, is described. The proposed reaction mechanism is also discussed.

关键词: 7-Ethyl-10-hydroxycamptothecin(SN-38), Mechanism, Synthesis

Abstract: The improved 3-step preparation of a key antitumor agent, 7-ethyl-10-hydroxycamptothecin(SN-38), which consists of ethylation, oxidation and photo-chemical rearrangement, is described. The proposed reaction mechanism is also discussed.

Key words: 7-Ethyl-10-hydroxycamptothecin(SN-38), Mechanism, Synthesis

LEI Ying-jie, ZHU Chun-hua, WANG Zuo-quan, LIU Hong. Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism[J]. 高等学校化学研究, 2001, 17(1): 69-72.

LEI Ying-jie, ZHU Chun-hua, WANG Zuo-quan, LIU Hong. Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism[J]. Chemical Research in Chinese Universities, 2001, 17(1): 69-72.

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Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism

Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism

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