Efficient Purification of Camptothecin via Aqueous Two-phase System Composed of 1,1,3,3-Tetramethylguanidinium Benzoate Ionic Liquid and K2CO3

doi:10.1007/s40242-016-5488-9

高等学校化学研究 ›› 2016, Vol. 32 ›› Issue (4): 630-633.doi: 10.1007/s40242-016-5488-9

Efficient Purification of Camptothecin via Aqueous Two-phase System Composed of 1,1,3,3-Tetramethylguanidinium Benzoate Ionic Liquid and K₂CO₃

ZHU Jian, JIN Zhimin

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China

收稿日期:2015-12-16 修回日期:2016-03-23 出版日期:2016-08-01 发布日期:2016-04-25
通讯作者: JIN Zhimin E-mail:zdjin99@sina.com
基金资助:
Supported by the Natural Science Foundation of Zhejiang Province, China(No.Y2100974).

Efficient Purification of Camptothecin via Aqueous Two-phase System Composed of 1,1,3,3-Tetramethylguanidinium Benzoate Ionic Liquid and K₂CO₃

ZHU Jian, JIN Zhimin

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China

Received:2015-12-16 Revised:2016-03-23 Online:2016-08-01 Published:2016-04-25
Contact: JIN Zhimin E-mail:zdjin99@sina.com
Supported by:
Supported by the Natural Science Foundation of Zhejiang Province, China(No.Y2100974).

摘要/Abstract

摘要：

After being hydrolyzed into corresponding hydrosoluble carboxylate by 1,1,3,3,-tetramethylguanidine (TMG), camptothecin was extracted via the aqueous two-phase systems composed of ionic liquid 1,1,3,3- tetramethylguanidinium(TMGM) carboxylate and K₂CO₃, and was regenerated at the final by dilute aqueous hydrochloric acid. Among the ionic liquids, TMGM benzoate showed the best effect, TMGM formate the worst, this results were consistent with the liposolubilities of different carboxylic acid components in the ionic liquids. Through two-step extraction of TMGM benzoate ionic liquid/K₂CO₃ aqueous two-phase under a favorable condition, camptothecin was obtained in a purity of 98.3% and a total yield of 85.1%, from the crude camptothecin extract with a purity of 14.2%.

关键词: Ionic liquid, Aqueous two-phase extraction, Camptothecin, 1,1,3,3-Tetramethylguanidine, Reversible hydrolysis

Abstract:

Key words: Ionic liquid, Aqueous two-phase extraction, Camptothecin, 1,1,3,3-Tetramethylguanidine, Reversible hydrolysis

ZHU Jian, JIN Zhimin. Efficient Purification of Camptothecin via Aqueous Two-phase System Composed of 1,1,3,3-Tetramethylguanidinium Benzoate Ionic Liquid and K₂CO₃[J]. 高等学校化学研究, 2016, 32(4): 630-633.

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Efficient Purification of Camptothecin via Aqueous Two-phase System Composed of 1,1,3,3-Tetramethylguanidinium Benzoate Ionic Liquid and K₂CO₃

Efficient Purification of Camptothecin via Aqueous Two-phase System Composed of 1,1,3,3-Tetramethylguanidinium Benzoate Ionic Liquid and K₂CO₃

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