Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction

doi:10.1007/s40242-014-4073-3

高等学校化学研究 ›› 2014, Vol. 30 ›› Issue (5): 770-773.doi: 10.1007/s40242-014-4073-3

Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction

LI Wei, HUANG Hai, JIN Xiaodong, LIU Yujian, XU Chaohang, ZHU Hongjun

Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China

收稿日期:2014-03-06 修回日期:2014-05-16 出版日期:2014-10-01 发布日期:2014-06-16
通讯作者: ZHU Hongjun E-mail:zhuhj@njtech.edu.cn
基金资助:
Supported by the National Key Technology R&D Program of China(No.2011BAE06A07-04).

Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction

LI Wei, HUANG Hai, JIN Xiaodong, LIU Yujian, XU Chaohang, ZHU Hongjun

Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China

Received:2014-03-06 Revised:2014-05-16 Online:2014-10-01 Published:2014-06-16
Contact: ZHU Hongjun E-mail:zhuhj@njtech.edu.cn
Supported by:
Supported by the National Key Technology R&D Program of China(No.2011BAE06A07-04).

摘要/Abstract

摘要：

The authors described a short and highly enantioselective route to (R)-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-(4-phenylbutoxy) hexyl methanesulfonate.

关键词: Asymmetric synthesis, Catalysis, Cyanohydrin, Ethanolamine, Methanesulfonate

Abstract:

Key words: Asymmetric synthesis, Catalysis, Cyanohydrin, Ethanolamine, Methanesulfonate

LI Wei, HUANG Hai, JIN Xiaodong, LIU Yujian, XU Chaohang, ZHU Hongjun. Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction[J]. 高等学校化学研究, 2014, 30(5): 770-773.

LI Wei, HUANG Hai, JIN Xiaodong, LIU Yujian, XU Chaohang, ZHU Hongjun. Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction[J]. Chemical Research in Chinese Universities, 2014, 30(5): 770-773.

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Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction

Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction

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