Development of NAMI-A-loaded PLGA-mPEG Nanoparticles: Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy

高等学校化学研究 ›› 2011, Vol. 27 ›› Issue (3): 345-349.

Development of NAMI-A-loaded PLGA-mPEG Nanoparticles: Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy

YANG Yong-guang¹, LIU Du¹, XIA Yu¹, ZHOU Yan-hui¹, ZHONG Xue-yun^2* and LIU Jie^1*

1. Department of Chemistry,
2. Medical College, Jinan University, Guangzhou 510632, P. R. China

收稿日期:2010-11-26 修回日期:2011-02-22 出版日期:2011-05-25 发布日期:2011-04-29
通讯作者: LIU Jie and ZHONG Xue-yun E-mail:tliuliu@jnu.edu.cn; tzxy@jnu.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(No.20871056), the Planned Item of Science and Technology of Guangdong Province, China (No.C1011220800060) and the “211” Project Grant of Jinan University.

Development of NAMI-A-loaded PLGA-mPEG Nanoparticles: Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy

YANG Yong-guang¹, LIU Du¹, XIA Yu¹, ZHOU Yan-hui¹, ZHONG Xue-yun^2* and LIU Jie^1*

1. Department of Chemistry,
2. Medical College, Jinan University, Guangzhou 510632, P. R. China

Received:2010-11-26 Revised:2011-02-22 Online:2011-05-25 Published:2011-04-29
Contact: LIU Jie and ZHONG Xue-yun E-mail:tliuliu@jnu.edu.cn; tzxy@jnu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.20871056), the Planned Item of Science and Technology of Guangdong Province, China (No.C1011220800060) and the “211” Project Grant of Jinan University.

摘要/Abstract

摘要： NAMI-A has showed extraordinary activities against metastatic tumors. However, the hydrolysis of DMSO from NAMI-A could reduce anti-metastatic activity. To enhance the circulation time and the anti-metastatic effect of NAMI-A, we first synthesized the NAMI-A-loaded nanoparticles. NAMI-A-loaded nanoparticles were prepared by the double emulsion method and characterized by scanning electron microscopy for surface morphology, laser light scattering for size and zeta potential for surface charge. Controlled release of NAMI-A was observed in a sustained manner. Compared with free NAMI-A, NAMI-A -loaded nanoparticles exhibited superior antitumor effect by delaying tumor growth in T739 mice. PLGA-mPEG nanoparticles are promising for further studies as drug delivery carriers.

关键词: PLGA-mPEG nanoparticles, NAMI-A, drug release, drug delivery, antitumor.

Abstract: NAMI-A has showed extraordinary activities against metastatic tumors. However, the hydrolysis of DMSO from NAMI-A could reduce anti-metastatic activity. To enhance the circulation time and the anti-metastatic effect of NAMI-A, we first synthesized the NAMI-A-loaded nanoparticles. NAMI-A-loaded nanoparticles were prepared by the double emulsion method and characterized by scanning electron microscopy for surface morphology, laser light scattering for size and zeta potential for surface charge. Controlled release of NAMI-A was observed in a sustained manner. Compared with free NAMI-A, NAMI-A -loaded nanoparticles exhibited superior antitumor effect by delaying tumor growth in T739 mice. PLGA-mPEG nanoparticles are promising for further studies as drug delivery carriers.

Key words: PLGA-mPEG nanoparticles, NAMI-A, drug release, drug delivery, antitumor.

YANG Yong-guang, LIU Du, XIA Yu, ZHOU Yan-hui, ZHONG Xue-yun* and LIU Jie*. Development of NAMI-A-loaded PLGA-mPEG Nanoparticles: Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy[J]. 高等学校化学研究, 2011, 27(3): 345-349.

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Development of NAMI-A-loaded PLGA-mPEG Nanoparticles: Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy

Development of NAMI-A-loaded PLGA-mPEG Nanoparticles: Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy

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