Fe3O4 Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide

高等学校化学研究 ›› 2011, Vol. 27 ›› Issue (4): 566-569.

Fe₃O₄ Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide

ZHANG Jin-lei^1,2, TAN Xue-cai^1*, ZHAO Dan-dan¹, TAN Sheng-wei¹, LIU Li¹, WANG Lin¹ and HUANG Zeng-wei¹

1. College of Chemistry and Ecological Engineering, Guangxi University for Nationalities, Nanning 530006, P. R. China;
2. Department of Chemistry and Life Science, Baise University, Baise 533000, P. R. China

收稿日期:2010-09-28 修回日期:2010-12-04 出版日期:2011-07-25 发布日期:2011-06-29
通讯作者: TAN Xue-cai E-mail:xctan@yahoo.cn
基金资助:
Supported by the National Natural Science Foundation of China(No.21065001), the Natural Science Foundation of Guangxi Province, China(Nos.0639025, 0991084), the Support Program for 100 Young and Middle-aged Disciplinary Leaders in Higher Education Institutions of Guangxi Province, China(No.RC20060703005), the Project of Key Laboratory of Development and Application of Forest Chemicals of Guangxi Province, China(No.GXFC08-06) and the Fund of Education Department of Guangxi Province, China(No.200812MS074).

Fe₃O₄ Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide

ZHANG Jin-lei^1,2, TAN Xue-cai^1*, ZHAO Dan-dan¹, TAN Sheng-wei¹, LIU Li¹, WANG Lin¹ and HUANG Zeng-wei¹

1. College of Chemistry and Ecological Engineering, Guangxi University for Nationalities, Nanning 530006, P. R. China;
2. Department of Chemistry and Life Science, Baise University, Baise 533000, P. R. China

Received:2010-09-28 Revised:2010-12-04 Online:2011-07-25 Published:2011-06-29
Contact: TAN Xue-cai E-mail:xctan@yahoo.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.21065001), the Natural Science Foundation of Guangxi Province, China(Nos.0639025, 0991084), the Support Program for 100 Young and Middle-aged Disciplinary Leaders in Higher Education Institutions of Guangxi Province, China(No.RC20060703005), the Project of Key Laboratory of Development and Application of Forest Chemicals of Guangxi Province, China(No.GXFC08-06) and the Fund of Education Department of Guangxi Province, China(No.200812MS074).

摘要/Abstract

摘要： A novel type of Fe3O4 nanoparticles modified glass carbon electrode(Fe3O4/GCE) was constructed and the electrochemical properties of N-(4-nitro-2-phenoxyphenyl)methanesulfonamide(nimesulide) were studied on the Fe3O4/GCE. In 0.4 mol/L HAc-NaAc buffer solution(pH=5.0), the electrode process of nimesulide was irreversible at bare GCE and Fe3O4/GCE. The Fe3O4/GCE exhibited a remarkable catalytic and enhancement effect on the reduction of nimesulide. The reduction peak potential of nimesulide shifted positively from –0.683 V at bare GCE to –0.625 V at Fe3O4/GCE, and the sensitivity was increased by ca. 3 times. Some experimental conditions were optimized. The linear range between the peak current and the concentration of nimesulide was 2.6×10–6―1.0×10–4 mol/L(R=0.993) with a detection limit of 1.3×10–7 mol/L. This method has been used to determine the content of nimesulide in medical tablets. The recovery was determined to be 96.9%―101.9% by means of standard addition method. The method is comparable to UV-Vis spectrometry.

关键词: Fe3O4 nanoparticle, Modified electrode, Nimesulide, Determination, Electrochemical behavior

Abstract: A novel type of Fe3O4 nanoparticles modified glass carbon electrode(Fe3O4/GCE) was constructed and the electrochemical properties of N-(4-nitro-2-phenoxyphenyl)methanesulfonamide(nimesulide) were studied on the Fe3O4/GCE. In 0.4 mol/L HAc-NaAc buffer solution(pH=5.0), the electrode process of nimesulide was irreversible at bare GCE and Fe3O4/GCE. The Fe3O4/GCE exhibited a remarkable catalytic and enhancement effect on the reduction of nimesulide. The reduction peak potential of nimesulide shifted positively from –0.683 V at bare GCE to –0.625 V at Fe3O4/GCE, and the sensitivity was increased by ca. 3 times. Some experimental conditions were optimized. The linear range between the peak current and the concentration of nimesulide was 2.6×10–6―1.0×10–4 mol/L(R=0.993) with a detection limit of 1.3×10–7 mol/L. This method has been used to determine the content of nimesulide in medical tablets. The recovery was determined to be 96.9%―101.9% by means of standard addition method. The method is comparable to UV-Vis spectrometry.

Key words: Fe3O4 nanoparticle, Modified electrode, Nimesulide, Determination, Electrochemical behavior

ZHANG Jin-lei, TAN Xue-cai*, ZHAO Dan-dan, TAN Sheng-wei, LIU Li, WANG Li, .... Fe₃O₄ Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide[J]. 高等学校化学研究, 2011, 27(4): 566-569.

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Fe₃O₄ Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide

Fe₃O₄ Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide

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