[an error occurred while processing this directive]

高等学校化学研究 ›› 2010, Vol. 26 ›› Issue (6): 981-985.

• Articles • 上一篇    下一篇

利用各种肝质粒还原代谢芳香硝基化合物

WANG Xingyong1,崔京南2,REN Weimin1,ZHAO Guoquan3,LI Feng1,QIAN Xuhong4   

  1. 1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China
    2. 大连理工大学
    3. School of Chemical Engineering and Technology, China University of Mining & Technology, Xuzhou 221008, China
    4. Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, China
  • 收稿日期:2009-11-06 修回日期:2010-03-23 出版日期:2010-11-25 发布日期:2010-11-09
  • 通讯作者: 崔京南 E-mail:jncui@dlut.edu.cn
  • 基金资助:
    利用生物转化法制备刚性稠环芳香手性醇;新一代生物催化和生物转化的科学基础

Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes

  • Received:2009-11-06 Revised:2010-03-23 Online:2010-11-25 Published:2010-11-09

摘要： 芳香硝基化合物在猪、鼠、鸡、牛、羊、海水鱼或淡水鱼肝质粒的体系中，以不同的反应活性、通过相应的芳香羟胺中间体还原降解为氨基化合物。猪、鼠和羊肝质粒对于4-硝基-1,2-二氰基苯1a表现出较高的还原活性，而鲤鱼肝质粒对这个底物缺乏反应活性。与1a底物相反，单氰基硝基苯2a却难于被猪肝质粒还原。与面包酵母及葡萄植物细胞相比较，这些动物肝质粒对芳香羟胺显示了更高的反应活性。

关键词: 肝质粒, 还原反应, 芳香硝基化合物, 芳香羟胺

Abstract: Nitroaromatic compounds were reductively metabolized to the corresponding amine compounds via the intermediate hydroxylamines by liver microsomes from pig, rat, chook, cattle, sheep, paralichthys olivaceus and cyprinoid in varied reactivity. Toward the 4-nitro-1,2-dicyanbenzen substrate 1a, the pig, rat and sheep livers exhibited the higher reactivity, and the cyprinoid was inefficient for the reduction. Contrasted to 1a, it was difficult to reduce the monocyannitrobenzene 2a by pig liver. Compared with the baker’s yeast and grape cells, the liver microsomes exhibited higher reactivity toward the hydroxylamines.

Key words: Liver microsomes, Reduction, Nitroaromatic compounds, Aromatic hydroxylamines