Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/Nanohydroxyapatite via Co-electrospinning Methods

高等学校化学研究 ›› 2010, Vol. 26 ›› Issue (4): 662-666.

Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/Nanohydroxyapatite via Co-electrospinning Methods

ZANG Jun-ting, QI Xin, LI Shu-qiang, LI Dong-song, GONG Yu-bao, YANG Chen, XU Feng and LIU Jian-guo*

Department of Bone and Joint Surgery, First Hospital of Jilin University, Changchun 130021, P. R. China

收稿日期:2009-12-10 修回日期:2010-04-30 出版日期:2010-07-25 发布日期:2010-10-01
通讯作者: LIU Jian-guoE-mail: jgliu.2005@yahoo.com.cn
基金资助:
Supported by the Scientific and Technological Developing Scheme of Jilin Province, China(No.20080302) and the Fund of Jilin Provincial Science and Technology Department, China(No.200705115).

Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/Nanohydroxyapatite via Co-electrospinning Methods

ZANG Jun-ting, QI Xin, LI Shu-qiang, LI Dong-song, GONG Yu-bao, YANG Chen, XU Feng and LIU Jian-guo*

Department of Bone and Joint Surgery, First Hospital of Jilin University, Changchun 130021, P. R. China

Received:2009-12-10 Revised:2010-04-30 Online:2010-07-25 Published:2010-10-01
Contact: LIU Jian-guoE-mail: jgliu.2005@yahoo.com.cn
Supported by:
Supported by the Scientific and Technological Developing Scheme of Jilin Province, China(No.20080302) and the Fund of Jilin Provincial Science and Technology Department, China(No.200705115).

摘要/Abstract

摘要： A novel scaffold containing collagen-I/polylactic acid(PLA)/nanohydroxyapatite(nHA) was prepared via co-electrospinning method. Different target substrates were used to improve the collection efficiency of this scaffold. The properties of the novel scaffold were compared with those of conventionally prepared ones. Compared to conventional method, the modified method was more efficient in producing the scaffold. Moreover, the porosity, thickness, and morphology of the novel scaffold were better than those of scaffolds prepared by conventional methods. The properties of collagen-I, collagen-I/PLA and collagen-I/PLA/nHA scaffolds were also compared. Diameters of the electrospun fibers ranged from 180 to 405 nm, and roughness was present on the surface of the fibers due to the deposition of crystals of nHA along the long axis of the fibers. The fibers of the collagen-I/PLA/nHA scaffold and the fibers of natural bone tissue had similar structure.

关键词: Electrospinning, Collagen-I, PLA, Nanohydroxyapatite

Abstract: A novel scaffold containing collagen-I/polylactic acid(PLA)/nanohydroxyapatite(nHA) was prepared via co-electrospinning method. Different target substrates were used to improve the collection efficiency of this scaffold. The properties of the novel scaffold were compared with those of conventionally prepared ones. Compared to conventional method, the modified method was more efficient in producing the scaffold. Moreover, the porosity, thickness, and morphology of the novel scaffold were better than those of scaffolds prepared by conventional methods. The properties of collagen-I, collagen-I/PLA and collagen-I/PLA/nHA scaffolds were also compared. Diameters of the electrospun fibers ranged from 180 to 405 nm, and roughness was present on the surface of the fibers due to the deposition of crystals of nHA along the long axis of the fibers. The fibers of the collagen-I/PLA/nHA scaffold and the fibers of natural bone tissue had similar structure.

Key words: Electrospinning, Collagen-I, PLA, Nanohydroxyapatite

ZANG Jun-ting, QI Xin, LI Shu-qiang, LI Dong-song, GONG Yu-bao, YANG Chen, .... Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/Nanohydroxyapatite via Co-electrospinning Methods[J]. 高等学校化学研究, 2010, 26(4): 662-666.

[1]	CHEN Minwen, LIAO Tao, ZENG Linsheng, ZENG Zhongyi, YANG Qinglai, WANG Guoxin. Plasmonic Gold Chip for Multiplexed Detection of Ovarian Cancer Biomarker in Urine[J]. 高等学校化学研究, 2022, 38(4): 935-940.
[2]	SUN Bolun, CHAO Danming, WANG Ce. Piezoelectric Nanogenerator Based on Electrospun Cellulose Acetate/Nanocellulose Crystal Composite Membranes for Energy Harvesting Application[J]. 高等学校化学研究, 2022, 38(4): 1005-1011.
[3]	LUO Zha, LIU Hao, SHEN Wei, SHI Kun, CHEN Ankang, SHENG Libo, SUI Yongming and ZOU Bo. Effects of High Pressure on the Surface Plasmon Resonance of Copper and Silver Nanocrystals[J]. 高等学校化学研究, 2022, 38(3): 843-846.
[4]	YANG Siran, AI Feixue, LI Ziping, ZHAO Guiyan, BI Yanfeng. N-Doped Carbon Nanofibers Encapsulating CoO@Co₉S₈ Nanoparticles: Preparation from S-Rich Co₃₂ Coordination Cluster Precursors by Electrospinning and Application for Superior Li-ion Storage[J]. 高等学校化学研究, 2022, 38(2): 603-608.
[5]	LI Jun, RONG Huazhen, CHEN Cong, LI Ziyi, ZUO Jiayu, WANG Wenjian, LIU Xinjian, GUAN Yixing, YANG Xiong, LIU Yingshu, ZOU Xiaoqin, ZHU Guangshan. Synthesis Optimization of SSZ-13 Zeolite Membranes by Dual Templates for N₂/NO₂ Separation[J]. 高等学校化学研究, 2022, 38(1): 250-256.
[6]	YOU Dongyu, ZHAO Yujuan, YANG Weiting, PAN Qinhe, LI Jiyang. Metal-Organic Framework-based Wood Aerogel for Effective Removal of Micro/Nano Plastics[J]. 高等学校化学研究, 2022, 38(1): 186-191.
[7]	Andy Shun-Hoi CHEUNG, Sammual Yu-Lut LEUNG, Franky Ka-Wah HAU, Vivian Wing-Wah YAM. Supramolecular Self-assembly of Amphiphilic Alkynyl-platinum(II) 2,6-Bis(N-alkylbenzimidazol-2'-yl) pyridine Complexes[J]. 高等学校化学研究, 2021, 37(5): 1079-1084.
[8]	LIU Zhenyu, DONG Jinyi, PAN Jiahao, ZHOU Chao, FAN Chunhai, WANG Qiangbin. Catalytic DNA Origami-based Chiral Plasmonic Biosensor[J]. 高等学校化学研究, 2021, 37(4): 914-918.
[9]	HUANG Hedong, GUO Zeyu, YANG Pengyan, CHEN Peng, Wu Jie. Electrical Conductivity, Oil Absorption and Electric Heating of Carbon Black-modified Carbon Nanofibers[J]. 高等学校化学研究, 2021, 37(3): 541-548.
[10]	BAI Shan, ZHANG Xiangyu, ZANG Leilei, YANG Songze, CHEN Xiaoqi, YUAN Xiaoyan. Electrospinning of Biomaterials for Vascular Regeneration[J]. 高等学校化学研究, 2021, 37(3): 394-403.
[11]	QIN Mei, LIU Daqing, DAI Zhang, MENG Xin, LIU Guosai, LIU Hao, HUANG Xiaowei, YAN Xu, CHEN Shaojuan. One Step Fabrication and Application of Antibacterial Electrospun Zein/Cinnamon Oil Membrane Wound Dressing via In situ Electrospinning Process[J]. 高等学校化学研究, 2021, 37(3): 464-469.
[12]	XIANG Huilin, ZHONG Lingling, REN Yongqing, LIU Dongmei, ZHU Zhigao, XU Ying, WANG Yu, WANG Wei. Superhydrophobized Polyacrylonitrile/Hierarchicall-FeOOH Nanofibrous Membrane for High-salinity Water Treatment in Membrane Distillation[J]. 高等学校化学研究, 2021, 37(3): 470-479.
[13]	CAO Wenhao, WANG Caifeng, WANG Shuai, ZHANG Yang, ZHAO Ruisheng. Preparation of Photoresponsive PAN-NH₂@EPESP Fiber Films with Mechanical Stability for Regulating Wettability and Micro-environment Humidity[J]. 高等学校化学研究, 2021, 37(3): 512-521.
[14]	FENG Zhendong, ZHANG Xiaopei, LIU Na, WANG Yue, ZHOU Ziyi, GLEBOV O. Oleg, WU Tong. Promotion of Neurite Outgrowth and Extension Using Injectable Welded Nanofibers[J]. 高等学校化学研究, 2021, 37(3): 522-527.
[15]	LUO Yu, GONG Xiaoyan Shawn, XU Zhiwei, MENG Kai, ZHANG Ke-Qin, ZHAO Huijing. PTFE Electrospun Stent Graft——Preparation, Properties and Its Industrialization Prospect[J]. 高等学校化学研究, 2021, 37(3): 589-597.

Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/Nanohydroxyapatite via Co-electrospinning Methods

Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/Nanohydroxyapatite via Co-electrospinning Methods

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价