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高等学校化学研究 ›› 2009, Vol. 25 ›› Issue (6): 861-865.

• Articles • 上一篇    下一篇

CuCl-catalyzed Oxidative N-Demethylation of Arylamines with tButyl Hydroperoxide

LIAO Qian and XI Chan-juan*   

  1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
  • 收稿日期:2008-12-08 修回日期:2009-02-14 出版日期:2009-11-25 发布日期:2010-01-25
  • 通讯作者: XI Chan-juan. E-mail: cjxi@tsinghua.edu.cn
  • 基金资助:

    Supported by the National Natural Science Foundation of China(No.20572058).

CuCl-catalyzed Oxidative N-Demethylation of Arylamines with tButyl Hydroperoxide

LIAO Qian and XI Chan-juan*   

  1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
  • Received:2008-12-08 Revised:2009-02-14 Online:2009-11-25 Published:2010-01-25
  • Contact: XI Chan-juan. E-mail: cjxi@tsinghua.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20572058).

Abstract:

CuCl-catalyzed oxidative N-demethylation of arylamines proceeded in the presence of tert-butyl hydroperoxide. The one-electron transfer route of oxidative N-demethylation competed favorably with the H-atom abstraction route.

Key words: Arylamine; Cuprous chloride; Catalytic oxidation; N-Demethylation; tert-Butyl hydroperoxide