Design and Synthesis of New Anti-AIDS Drugs——Introducing an Immunomodulator into Delavirdine Derivative

高等学校化学研究 ›› 2009, Vol. 25 ›› Issue (6): 856-860.

Design and Synthesis of New Anti-AIDS Drugs——Introducing an Immunomodulator into Delavirdine Derivative

LU Hai-bin¹, MI Hao-yu¹, CUI Lin-lin², YU Xiang-Hui¹, LIANG Tie^3* and WANG En-si^1,2*

1. College of Life Science,
2. School of Pharmacy, Jilin University, Changchun 130021, P. R. China;
3. Affiliated Hospital, Changchun Chinese Medicine University, Changchun 130061, P. R. China

收稿日期:2008-11-10 修回日期:2009-01-05 出版日期:2009-11-25 发布日期:2010-01-25
通讯作者: WANG En-si, E-mail: wangss@jlu.edu.cn; LIANG Tie, E-mail: jlcbslt@vip.sina.com
基金资助:
Supported by Scientific and Technological Development Program Foundation of Jilin Province, China(No.20020503-11).

Design and Synthesis of New Anti-AIDS Drugs——Introducing an Immunomodulator into Delavirdine Derivative

LU Hai-bin¹, MI Hao-yu¹, CUI Lin-lin², YU Xiang-Hui¹, LIANG Tie^3* and WANG En-si^1,2*

1. College of Life Science,
2. School of Pharmacy, Jilin University, Changchun 130021, P. R. China;
3. Affiliated Hospital, Changchun Chinese Medicine University, Changchun 130061, P. R. China

Received:2008-11-10 Revised:2009-01-05 Online:2009-11-25 Published:2010-01-25
Contact: WANG En-si, E-mail: wangss@jlu.edu.cn; LIANG Tie, E-mail: jlcbslt@vip.sina.com
Supported by:
Supported by Scientific and Technological Development Program Foundation of Jilin Province, China(No.20020503-11).

摘要/Abstract

Abstract:

In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug(compounds 5 and 7) was synthesized. Compound 5 was synthesized by linking the delavirdine derivative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of ¹H NMR, ¹³C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-AIDs drug has been synthesized.

Key words: Synthesis; AIDS; Conjugated compound

LU Hai-bin, MI Hao-yu, CUI Lin-lin, YU Xiang-Hui, LIANG Tie* and WANG En-si. Design and Synthesis of New Anti-AIDS Drugs——Introducing an Immunomodulator into Delavirdine Derivative[J]. 高等学校化学研究, 2009, 25(6): 856-860.

Design and Synthesis of New Anti-AIDS Drugs——Introducing an Immunomodulator into Delavirdine Derivative

Design and Synthesis of New Anti-AIDS Drugs——Introducing an Immunomodulator into Delavirdine Derivative

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价