Formation of Electrospun Membranes with High Resilience by In situ Crosslinking

doi:10.1007/s40242-025-5026-8

高等学校化学研究 ›› 2025, Vol. 41 ›› Issue (3): 620-628.doi: 10.1007/s40242-025-5026-8

Formation of Electrospun Membranes with High Resilience by In situ Crosslinking

WANG Qing¹, YUAN Liang¹, ZHU Kongying², REN Lixia¹, YUAN Xiaoyan¹

1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, P. R. China;
2. Analysis and Measurement Center, Tianjin University, Tianjin 300072, P. R. China

收稿日期:2025-02-13 修回日期:2025-03-05 出版日期:2025-06-01 发布日期:2025-05-27
通讯作者: YUAN Xiaoyan,E-mail:yuanxy@tju.edu.cn E-mail:yuanxy@tju.edu.cn
基金资助:
This work was supported by the National Natural Science Foundation of China (No. 52073204).

Formation of Electrospun Membranes with High Resilience by In situ Crosslinking

WANG Qing¹, YUAN Liang¹, ZHU Kongying², REN Lixia¹, YUAN Xiaoyan¹

1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, P. R. China;
2. Analysis and Measurement Center, Tianjin University, Tianjin 300072, P. R. China

Received:2025-02-13 Revised:2025-03-05 Online:2025-06-01 Published:2025-05-27
Contact: YUAN Xiaoyan,E-mail:yuanxy@tju.edu.cn E-mail:yuanxy@tju.edu.cn
Supported by:
This work was supported by the National Natural Science Foundation of China (No. 52073204).

摘要/Abstract

摘要： Elasticity of biodegradable fibrous scaffolds is one of essential requirements for soft tissue regeneration, and sufficient compliance of small-diameter vascular grafts is necessary. In this work, electrospun fibrous membranes with high resilience are prepared through blend electrospinning of poly(ɛ-caprolactone) (PCL)/methacrylated poly(glycerol sebacate) (PGS) and in situ photo-crosslinking with poly(ethylene glycol) diacrylate. The obtained PCL/PGS electrospun membranes have minor hemolysis, low platelet adherence, and favorable cytocompatibility. In the wet state, the PCL/PGS electrospun membranes in 5/5 or 4/6 mass ratio exhibit lowered modulus and reversible deformation with improved compliance in comparison with PCL, which can be comparable to the human saphenous vein. This study provides a feasible way to prepare electrospun fibrous scaffolds with high elasticity, that can be suitable for applications in vascular regeneration and relative soft tissue repair.

关键词: Poly(glycerol sebacate), Poly(ɛ-caprolactone), Blend electrospinning, In situ crosslinking, Mechanical property

Abstract: Elasticity of biodegradable fibrous scaffolds is one of essential requirements for soft tissue regeneration, and sufficient compliance of small-diameter vascular grafts is necessary. In this work, electrospun fibrous membranes with high resilience are prepared through blend electrospinning of poly(ɛ-caprolactone) (PCL)/methacrylated poly(glycerol sebacate) (PGS) and in situ photo-crosslinking with poly(ethylene glycol) diacrylate. The obtained PCL/PGS electrospun membranes have minor hemolysis, low platelet adherence, and favorable cytocompatibility. In the wet state, the PCL/PGS electrospun membranes in 5/5 or 4/6 mass ratio exhibit lowered modulus and reversible deformation with improved compliance in comparison with PCL, which can be comparable to the human saphenous vein. This study provides a feasible way to prepare electrospun fibrous scaffolds with high elasticity, that can be suitable for applications in vascular regeneration and relative soft tissue repair.

Key words: Poly(glycerol sebacate), Poly(ɛ-caprolactone), Blend electrospinning, In situ crosslinking, Mechanical property

WANG Qing, YUAN Liang, ZHU Kongying, REN Lixia, YUAN Xiaoyan. Formation of Electrospun Membranes with High Resilience by In situ Crosslinking[J]. 高等学校化学研究, 2025, 41(3): 620-628.

WANG Qing, YUAN Liang, ZHU Kongying, REN Lixia, YUAN Xiaoyan. Formation of Electrospun Membranes with High Resilience by In situ Crosslinking[J]. Chemical Research in Chinese Universities, 2025, 41(3): 620-628.

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Formation of Electrospun Membranes with High Resilience by In situ Crosslinking

Formation of Electrospun Membranes with High Resilience by In situ Crosslinking

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