Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes

doi:10.1007/s40242-024-3262-y

高等学校化学研究 ›› 2024, Vol. 40 ›› Issue (6): 1050-1059.doi: 10.1007/s40242-024-3262-y

Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes

XU Dejun^1,3, HE Liu¹, ZENG Fudong^1,3, LIU Bo², MA Jinli^1,3, HAN Dongmei^1,3, YANG Qingbiao², DU Jianshi^1,3

1. China-Japan Union Hospital of Jilin University, Changchun 130061, P. R. China;
2. College of Chemistry, Jilin University, Changchun 130021, P. R. China;
3. Key Laboratory of Lymphatic Surgery of Jilin Province, Engineering Laboratory of Lymphatic Surgery of Jilin Province, Changchun 130031, P. R. China

收稿日期:2023-11-28 出版日期:2024-12-01 发布日期:2024-10-26
通讯作者: HAN Dongmei,handm@jlu.edu.cn;YANG Qingbiao,yangqb@jlu.edu.cn;DU Jianshi,dujs@jlu.edu.cn E-mail:handm@jlu.edu.cn;yangqb@jlu.edu.cn;dujs@jlu.edu.cn
基金资助:
This work was supported by the Jilin Provincial Development and Reform Commission Industrial Technology Research and Development Project, China (No. 2023C039-5), the Jilin Province Science and Technology Development Plan Project, China (No. 20210204107YY), and the Jilin Province Health Technology Capability Enhancement Project, China (No. 2021LC028).

Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes

XU Dejun^1,3, HE Liu¹, ZENG Fudong^1,3, LIU Bo², MA Jinli^1,3, HAN Dongmei^1,3, YANG Qingbiao², DU Jianshi^1,3

1. China-Japan Union Hospital of Jilin University, Changchun 130061, P. R. China;
2. College of Chemistry, Jilin University, Changchun 130021, P. R. China;
3. Key Laboratory of Lymphatic Surgery of Jilin Province, Engineering Laboratory of Lymphatic Surgery of Jilin Province, Changchun 130031, P. R. China

Received:2023-11-28 Online:2024-12-01 Published:2024-10-26
Contact: HAN Dongmei,handm@jlu.edu.cn;YANG Qingbiao,yangqb@jlu.edu.cn;DU Jianshi,dujs@jlu.edu.cn E-mail:handm@jlu.edu.cn;yangqb@jlu.edu.cn;dujs@jlu.edu.cn
Supported by:
This work was supported by the Jilin Provincial Development and Reform Commission Industrial Technology Research and Development Project, China (No. 2023C039-5), the Jilin Province Science and Technology Development Plan Project, China (No. 20210204107YY), and the Jilin Province Health Technology Capability Enhancement Project, China (No. 2021LC028).

摘要/Abstract

摘要： Polyvinylpyrrolidone-iodine (PVP-I) complexes are widely used in the medical and health field due to its strong antimicrobial properties and good biocompatibility, but their water solubility negates the possibility to be used as a wound dressing. In this work, the problem of PVP dissolving in water was solved by the method of thermally crosslinking, and it was found that the thermally crosslinked PVP nanofiber heated at 170 ℃ for 6 h had good liquid absorption capacity, stability and good fiber morphology. In addition, the thermally crosslinked PVP nanofiber is complexed with I₂ to endow it with excellent antibacterial properties. It has been demonstrated to have good biocompatibility through cytotoxicity and hemolysis experiments, which provides the possibility for it to be a dressing for the treatment of infectious wounds.

关键词: Electrospinning, Nanofiber membrane, Thermally crosslinked polyvinylpyrrolidone (PVP), Antimicrobial, Biocompatibility

Abstract: Polyvinylpyrrolidone-iodine (PVP-I) complexes are widely used in the medical and health field due to its strong antimicrobial properties and good biocompatibility, but their water solubility negates the possibility to be used as a wound dressing. In this work, the problem of PVP dissolving in water was solved by the method of thermally crosslinking, and it was found that the thermally crosslinked PVP nanofiber heated at 170 ℃ for 6 h had good liquid absorption capacity, stability and good fiber morphology. In addition, the thermally crosslinked PVP nanofiber is complexed with I₂ to endow it with excellent antibacterial properties. It has been demonstrated to have good biocompatibility through cytotoxicity and hemolysis experiments, which provides the possibility for it to be a dressing for the treatment of infectious wounds.

Key words: Electrospinning, Nanofiber membrane, Thermally crosslinked polyvinylpyrrolidone (PVP), Antimicrobial, Biocompatibility

XU Dejun, HE Liu, ZENG Fudong, LIU Bo, MA Jinli, HAN Dongmei, YANG Qingbiao, DU Jianshi. Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes[J]. 高等学校化学研究, 2024, 40(6): 1050-1059.

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Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes

Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes

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