Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies

doi:10.1007/s40242-023-3039-8

高等学校化学研究 ›› 2023, Vol. 39 ›› Issue (3): 342-360.doi: 10.1007/s40242-023-3039-8

Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies

Zhihua Ren¹, Tingting Ku¹, Mengyao Ren¹, Jiefeng Liang³, Xia Ning¹, Hanqing Xu⁴, Danqin Ren¹, Qunfang Zhou², Nan Sang¹

1. College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, 030006, P. R. China;
2. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China;
3. Shandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao, Qingdao, 266237, P. R. China;
4. National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, Wenzhou University, Wenzhou, 325035, P. R. China

收稿日期:2023-02-23 出版日期:2023-06-01 发布日期:2023-05-25
通讯作者: Nan Sang E-mail:sangnan@sxu.edu.cn
基金资助:
This work was supported by the National Science Foundation of China (Nos.22036005, 22176119, 92043301, 22006096), the National Key R&D Program of China(No.2018YFA0901101), the Natural Science Foundation of Shanxi Province, China(No.202203021222002), and the Special Fund for Science and Technology Innovation Teams of Shanxi Province, China (No.202204051002024).

Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies

REN Zhihua, KU Tingting, REN Mengyao, LIANG Jiefeng, NING Xia, XU Hanqing, REN Danqin, ZHOU Qunfang, SANG Nan

1. College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, 030006, P. R. China;
2. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China;
3. Shandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao, Qingdao, 266237, P. R. China;
4. National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, Wenzhou University, Wenzhou, 325035, P. R. China

Received:2023-02-23 Online:2023-06-01 Published:2023-05-25
Contact: Nan Sang E-mail:sangnan@sxu.edu.cn
Supported by:
This work was supported by the National Science Foundation of China (Nos.22036005, 22176119, 92043301, 22006096), the National Key R&D Program of China(No.2018YFA0901101), the Natural Science Foundation of Shanxi Province, China(No.202203021222002), and the Special Fund for Science and Technology Innovation Teams of Shanxi Province, China (No.202204051002024).

摘要/Abstract

摘要： The increasing production and extensive application of chemicals have led to their unintended release and contamination in the environment, posing a hazardous threat to wildlife and human health. Numerous studies have demonstrated that developmental toxicity could be induced by various emerging chemicals, causing abnormal embryonic and placental development, adverse pregnancy outcomes, obesity, and dysfunction of lipid metabolism in neonates. Given the currently-available experimental technology for developmental toxicological studies, an in vitro model based on stem cells showed promising performance in high-throughput screening of the early-stage developmental toxicity of emerging chemicals. In this review, the deleterious effects of environmental pollutants on stem cells were systemically assorted from the aspects of cytological dysfunction, self-renewal impairment, perturbation in embryoid body(EB) formation, and disruption of committed lineage differentiation. The toxicological data on the molecular level, including the altered expressions of gene and protein biomarkers, epigenomic regulation, and enhanced oxidative stress, were collected and summarized to provide the mechanism explanation for the link between environmental pollutant exposure and unfavorable phenotypes in stem cells. The advantage of the stem cell model in developmental toxicological studies was specifically emphasized. And the perspectives for stem cells were ultimately highlighted in the research field of environmental toxicology, especially developmental toxicology during the early stage of life.

关键词: Environmental pollutant, Developmental toxicology, Stem cell, Early-stage life, Health effect

Abstract: The increasing production and extensive application of chemicals have led to their unintended release and contamination in the environment, posing a hazardous threat to wildlife and human health. Numerous studies have demonstrated that developmental toxicity could be induced by various emerging chemicals, causing abnormal embryonic and placental development, adverse pregnancy outcomes, obesity, and dysfunction of lipid metabolism in neonates. Given the currently-available experimental technology for developmental toxicological studies, an in vitro model based on stem cells showed promising performance in high-throughput screening of the early-stage developmental toxicity of emerging chemicals. In this review, the deleterious effects of environmental pollutants on stem cells were systemically assorted from the aspects of cytological dysfunction, self-renewal impairment, perturbation in embryoid body(EB) formation, and disruption of committed lineage differentiation. The toxicological data on the molecular level, including the altered expressions of gene and protein biomarkers, epigenomic regulation, and enhanced oxidative stress, were collected and summarized to provide the mechanism explanation for the link between environmental pollutant exposure and unfavorable phenotypes in stem cells. The advantage of the stem cell model in developmental toxicological studies was specifically emphasized. And the perspectives for stem cells were ultimately highlighted in the research field of environmental toxicology, especially developmental toxicology during the early stage of life.

Key words: Environmental pollutant, Developmental toxicology, Stem cell, Early-stage life, Health effect

Zhihua Ren, Tingting Ku, Mengyao Ren, Jiefeng Liang, Xia Ning, Hanqing Xu, Danqin Ren, Qunfang Zhou, Nan Sang. Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies[J]. 高等学校化学研究, 2023, 39(3): 342-360.

REN Zhihua, KU Tingting, REN Mengyao, LIANG Jiefeng, NING Xia, XU Hanqing, REN Danqin, ZHOU Qunfang, SANG Nan. Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies[J]. Chemical Research in Chinese Universities, 2023, 39(3): 342-360.

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Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies

Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies

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