Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2'-bipyridyl)ruthenium(II) Chloride-diperiodatocuprate(III) Reaction

doi:10.1007/s40242-020-0339-0

高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (3): 629-638.doi: 10.1007/s40242-020-0339-0

Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2'-bipyridyl)ruthenium(II) Chloride-diperiodatocuprate(III) Reaction

AHMED Khan, MUHAMMAD Asghar, MOHAMMED Yaqoob, MASOOD Ahmed Siddiqui, SAMAR Ali

Department of Chemistry, University of Balochistan, Sariab Road, Quetta-87300, Pakistan

收稿日期:2020-10-24 修回日期:2020-11-08 出版日期:2021-06-01 发布日期:2020-11-18
通讯作者: MOHAMMED Yaqoob E-mail:yaqoob2001@hotmail.com
基金资助:
The authors acknowledge the Department of Chemistry, University of Balochistan, Quetta, Pakistan for providing research facilities.

Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2'-bipyridyl)ruthenium(II) Chloride-diperiodatocuprate(III) Reaction

AHMED Khan, MUHAMMAD Asghar, MOHAMMED Yaqoob, MASOOD Ahmed Siddiqui, SAMAR Ali

Department of Chemistry, University of Balochistan, Sariab Road, Quetta-87300, Pakistan

Received:2020-10-24 Revised:2020-11-08 Online:2021-06-01 Published:2020-11-18
Contact: MOHAMMED Yaqoob E-mail:yaqoob2001@hotmail.com
Supported by:
The authors acknowledge the Department of Chemistry, University of Balochistan, Quetta, Pakistan for providing research facilities.

摘要/Abstract

摘要： Asensitive and selective method employing chemiluminescence(CL) coupled with flow injection(FI) is reported for nalbuphine hydrochloride(NAL) assay in pharmaceutical formulations. The enhancement effect of NAL on the CL reaction between tris(2,2'-bipyridyl)ruthenium(II) chloride-diperiodatocuprate(III) {Ru[(bpy)₃]²⁺-Cu(III) complex} in acidic medium is used as analytical measurement. The optimal conditions of the CL reaction were sulfuric acid 1.0×10^-3 mol/L, Ru[(bpy)₃]²⁺ 7.5×10^-5 mol/L, Cu(III)/Ag(III) complexes 4.0×10^-4/5.0×10^-4 mol/L, sample loop volume of 120 μL and flow rate of 2.5 mL/min. The sensitivities of the method in terms of detection(S/N=3) and quantification(S/N=10) limits are 5×10^-4 and 0.001 ppm(1 ppm=1 mg/L), respectively. The linear response of the instrument in the form of CL intensity with respect to NAL concentration is over the range 0.001-15.0 ppm(R²=0.9999) with relative standard deviation from 0.8% to 3.2% and injection throughput of 120 injection/h. The applications of the method include the quantitative analysis of NAL in pharmaceutical injection samples. Variations and the average results of the proposed method are not signi-ficantly different from the results of a reported method by applying F- and paired student t-test. The most likely CL reaction mechanism is written in accordance with spectrophotometric and CL studies.

关键词: Ru[(bpy)₃]²⁺, Cu(III)/Ag(III) complex, Chemiluminescence, Flow injection analysis, Nalbuphine hydrochloride, Pharmaceutical

Abstract: Asensitive and selective method employing chemiluminescence(CL) coupled with flow injection(FI) is reported for nalbuphine hydrochloride(NAL) assay in pharmaceutical formulations. The enhancement effect of NAL on the CL reaction between tris(2,2'-bipyridyl)ruthenium(II) chloride-diperiodatocuprate(III) {Ru[(bpy)₃]²⁺-Cu(III) complex} in acidic medium is used as analytical measurement. The optimal conditions of the CL reaction were sulfuric acid 1.0×10^-3 mol/L, Ru[(bpy)₃]²⁺ 7.5×10^-5 mol/L, Cu(III)/Ag(III) complexes 4.0×10^-4/5.0×10^-4 mol/L, sample loop volume of 120 μL and flow rate of 2.5 mL/min. The sensitivities of the method in terms of detection(S/N=3) and quantification(S/N=10) limits are 5×10^-4 and 0.001 ppm(1 ppm=1 mg/L), respectively. The linear response of the instrument in the form of CL intensity with respect to NAL concentration is over the range 0.001-15.0 ppm(R²=0.9999) with relative standard deviation from 0.8% to 3.2% and injection throughput of 120 injection/h. The applications of the method include the quantitative analysis of NAL in pharmaceutical injection samples. Variations and the average results of the proposed method are not signi-ficantly different from the results of a reported method by applying F- and paired student t-test. The most likely CL reaction mechanism is written in accordance with spectrophotometric and CL studies.

Key words: Ru[(bpy)₃]²⁺, Cu(III)/Ag(III) complex, Chemiluminescence, Flow injection analysis, Nalbuphine hydrochloride, Pharmaceutical

AHMED Khan, MUHAMMAD Asghar, MOHAMMED Yaqoob, MASOOD Ahmed Siddiqui, SAMAR Ali. Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2'-bipyridyl)ruthenium(II) Chloride-diperiodatocuprate(III) Reaction[J]. 高等学校化学研究, 2021, 37(3): 629-638.

参考文献 53

[1]	Pick C. G., Paul D., Pasternak G. W., J. Pharmacol. Exp. Ther., 1992, 262, 1044
[2]	Presten K. L., Jasinski D. R., Drug Alcohol Depen., 1991, 28, 49
[3]	Lake C. L., Duckworth E. N., DiFazio C. A., Durbin C. G., Magruder M. R., Anesthesiology, 1982, 57, 498
[4]	Miller R. R., Am. J. Hosp. Pharm., 1980, 37, 942
[5]	Schnabel A., Reichl S. U., Zahn P. K., Pogatzki-Zahn E., Cochrane Database of Syst. Rev., 2014, 7, CD009583
[6]	Quarry M. A., Williams R. C., Sebastian D. S., J. Liq. Chromatogr. R. T., 1998, 21, 2841
[7]	Groenendaal D., Blom-Roosemalen M. C., Danhof M., de Lange E. C., J. Chromatogr. B, 2005, 822, 230
[8]	Attia K. A., Nassar M. W., El-Olemy A., Int. J. Res. Pharmaceut. Biomed. Sci., 2014, 1, 15
[9]	Huang P. W., Liu H. T., Hsiong C. H., Pao L. H., Lu C. C., Ho S. T., Hu O. Y. P., Biomed. Chromatogr., 2013, 27, 831
[10]	Cai L. J., Zhang J., Wang X. M., Zhu R. H., Yang J., Zhang Q. Z., Peng W. X., Biomed. Chromatogr., 2011, 25, 1308
[11]	Weinstein S. H., Alteras M., Gaylord J. J. Pharm. Sci., 1978, 67, 547
[12]	Yoo Y. C., Chung H. S., Kim I. S., Jin W. T., Kim M. K., J. Anal. Toxicol., 1995, 19, 120
[13]	Kim J. Y., In M. K., Paeng K. J., Chung B. C., Chromatographia, 2004, 59, 219
[14]	Alarfaj N., El-Tohamy M. F., J. Chromatogr. Sep. Tech., 2016, 7, 2
[15]	Atta N. F., Galal A., Hassan S. H., J. Electroanal. Chem., 2019, 839, 48
[16]	Cheraghi S., Taher M. A., Karimi-Maleh H., Moradi, R., J. Electrochem. Soc., 2017, 164, B60
[17]	Fouladgar M., Sens. Actuators B Chem., 2016, 230, 456
[18]	Shaikh T., Nafady A., Talpur F. N., Agheem M. H., Shah M. R., Sherazi S. T. H., Soomro R. A. Siddiqui S. Sens. Actuators B Chem., 2015, 211, 359
[19]	El-Tohamy M., El-Maamly M., Shalaby A., Aboul-Enein H. Y., Anal. Lett., 2007, 40, 1569
[20]	El Sharkasy M. E., Walash M., Belal F., Salim M. M., Spectrochim. Acta A, 2020, 228, 117841
[21]	Abdullah L. M., Attia M., Abdel-Mottaleb M. S., Egyptian J. Chem., 2019, 62, 247
[22]	Attia K. A., Nassar M. W., Allam A. E. O., Int. J. Pharm. Sci. Res., 2014, 5, 1253
[23]	El-Didamony A. M., Ali I. I., Luminescence, 2013, 28, 745
[24]	Belal F., Ibrahim F., Sheribah Z. A., Alaa H., Spectrochim. Acta A, 2018, 198, 51
[25]	El-Didamony A. M., Saad M. Z., Saleem N. O., J. Assoc. Arab Univ. Basic Appl. Sci., 2015, 17, 43
[26]	Attia K. A. S., Nassar M. W., El-Olemy A., Eur. J. Pharm. Sci., 2014, 1, 1
[27]	El-Didamony A. M., Saad M. Z., Saleem N. O., J. Chil. Chem. Soc., 2013, 58, 1907
[28]	Garcia-Campana A. M., Baeyens W. R. G., Chemiluminescence in Analy-tical Chemistry, Marcel Dekker, New York, 2001
[29]	Su Y., Chen H., Wang Z., Lv Y., Appl. Spectrosc. Rev., 2007, 42, 139
[30]	Gerardi R. D., Barnett N. W., Lewis S. W., Anal. Chim. Acta, 1999, 378, 1
[31]	Gorman B. A., Francis P. S., Barnett N. W., Analyst, 2006, 131, 616
[32]	Lara F. J., Garcia-Campana A. M., Aaron J. J., Anal. Chim. Acta, 2010, 679, 17
[33]	Christodouleas D., Fotakis C., Economou A., Papadopoulos K., Timo-theou-Potamia M., Calokerinos A., Anal. Lett., 2011, 44, 176
[34]	López-Paz J. L., Catalá-Icardo M., Anal. Lett., 2011, 44, 146
[35]	Chen J., Fang Y., Sensors, 2007, 7, 448
[36]	Adcock J. L., Barnett N. W., Barrow C. J., Francis P. S., Anal. Chim. Acta, 2014, 807, 9
[37]	Waseem A., Yaqoob M., Nabi A., Curr. Pharm. Anal., 2013, 9, 363
[38]	Timofeeva I. I., Vakh C. S., Bulatov A. V., Worsfold P. J., Talanta, 2018, 179, 246
[39]	Su M., Chen P., Sun H. TrAC-Trend. Anal. Chem., 2018, 100, 36
[40]	Khan A., Asghar M., Yaqoob M., Anal. Sci., 2020, 20P126
[41]	Jose T. P., Tuwar S. M., J. Mol. Struct., 2007, 827, 137
[42]	Balikungeri A., Pelletier M., Monnier D., Inorg. Chim. Acta, 1977, 22, 7
[43]	Yang C., Zhang Z., Wang J. Microchim. Acta, 2009, 167, 91
[44]	Li Z. T., Wang F. L., Wang A. Z., Int. J. Chem. Kinet., 1992, 24, 933
[45]	Wu Z. J., Zhang Z. B., Liu L. S., Electrochim. Acta, 1997, 42, 2719
[46]	Hu Y., Li G., Zhang Z., Luminescence, 2011, 26, 313
[47]	Sun H., Wang J., Wang, T., Luminescence, 2013, 28, 592
[48]	Zhang Y., Zhang Z., Sun Y., Wei Y., J. Agric. Food Chem., 2007, 55, 4949
[49]	Hu Y., Zhang Z., Luminescence, 2008, 23, 338
[50]	Li T., Wang Z., Xie H., Fu Z. J. Chromatogr. B, 2012, 911, 1
[51]	Yang C., Zhang Z., Wang J., Spectrochim. Acta Part A, 2010, 75, 77
[52]	Hu Y., Zhang Z., Yang C., Anal. Chim. Acta, 2007, 601, 95
[53]	Yao H., Zhang M., Zeng W., Zeng X., Zhang Z., Spectrochim. Acta A, 2014, 117, 645

Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2'-bipyridyl)ruthenium(II) Chloride-diperiodatocuprate(III) Reaction

Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2'-bipyridyl)ruthenium(II) Chloride-diperiodatocuprate(III) Reaction

可视化

摘要/Abstract

引用本文

使用本文

参考文献 53

相关文章 15

编辑推荐

Metrics

本文评价

[1]	HU Shifan, WANG Yafeng and SU Bin. Effect of Ionic Strength on the Electrochemiluminescence Generation by Tris(2,2'-bipyridyl)ruthenium(II)/Tri-n-propylamine[J]. 高等学校化学研究, 2022, 38(3): 816-822.
[2]	MUHAMMAD Yousaf, MOHAMMED Yaqoob, MUHAMMAD Asghar, SAMAR Ali. Chemiluminescence Determination of Cefixime Trihydrate Based on Acidic Diperiodatoargentate(Ⅲ)-Rhodamine 6-G System[J]. 高等学校化学研究, 2019, 35(5): 775-781.
[3]	Muhammad ASGHAR, Mohammad YAQOOB, Abdul NABI. Chemiluminescent Determination of Cyromazine in Milk Samples Using Copper (III) Chelate-Triton X-100 by Flow Injection Analysis[J]. 高等学校化学研究, 2017, 33(3): 354-359.
[4]	TRAORE Zoumana Sékou, SU Xing-guang . Determination of Biotin in Pharmaceutical Formulations by Potassium Permanganate-luminol-CdTe Nanoparticles Chemiluminescence System[J]. 高等学校化学研究, 2012, 28(4): 604-608.
[5]	WASEEM Amir*, YAQOOB Mohammad, NABI Abdul, MURTAZA Ghulam and HUSSAIN Izhar. Flow-injection Spectrophotometric Determination of Uric Acid in Urine via Prussian Blue Reaction[J]. 高等学校化学研究, 2011, 27(6): 929-933.
[6]	YU Cai-xia, YUAN Bai-qing and YOU Tian-yan*. Enantiomeric Separation of Antidepressant Trimipramine by Capillary Electrophoresis Combined with Electrochemiluminescence Detection in Aqueous-organic Media[J]. 高等学校化学研究, 2011, 27(1): 34-37.
[7]	WASEEM Amir*, YAQOOB Mohammad and NABI Abdul. Flow-injection Determination of Cysteine, N-Acetyl Cysteine and Glutathione in Pharmaceuticals via Potassium Ferricyanide-Fe(III) Spectrophotometric System[J]. 高等学校化学研究, 2010, 26(6): 893-898.
[8]	ZHOU Xiao-guang, YUAN Bai-qing, ZHANG Lei, LIU Yang, HAN Dong-xue and YOU Yang. Determination of Amino Acids by Ru(bpy)₃²⁺ Cathodic Electrochemiluminescence with High Sensitivity[J]. 高等学校化学研究, 2010, 26(3): 376-379.
[9]	LI Xiao-zhou, GUAN Ting-ting, ZHOU Chi, YIN Ji-qiu, ZHANG Yi-hua. Solid Phase Extraction Chemiluminescence Determination of Methamidaphos on Vegetables[J]. 高等学校化学研究, 2006, 22(1): 21-24.
[10]	LI Li-jun, CHENG Hao, ZHAO Chuan, HU Xiao-ge. Determination of Vitamin B1 in Pharmaceutical Preparations by Flow-injection Analysis with Biamperometric Detection[J]. 高等学校化学研究, 2005, 21(6): 650-653.
[11]	WANG An-bao, Joseph F. Foss, YUAN Chun-su, Joachim Osinski. Separation and Determination of Methylnaltrexone in Human Plasma Samples After Oral Administration by HPLC Coupled with Electrochemical Detection[J]. 高等学校化学研究, 2005, 21(3): 268-273.
[12]	ZHANG Shu-dong, LI Hai-Yang. Formation Mechanism and Emission Spectrum of AlO Radicals in Reaction of Laser-ablated Al Atom and Oxygen[J]. 高等学校化学研究, 2003, 19(3): 320-323.
[13]	LI Ying-xiu, ZHU Lian-de, ZHU Guo-yi. A Novel Flow Injection Optical Fiber Biosensor for Hypoxanthine Based on Luminol Electrochemiluminescence[J]. 高等学校化学研究, 2003, 19(2): 240-244.
[14]	ZHANG Si-chun, ZHOU Guo-jun, JU Huang-xian. Chemiluminescence Sensor for the Determination of Hydroxylamine by Electrostatically Immobilizing Luminol and Periodate[J]. 高等学校化学研究, 2003, 19(2): 155-159.
[15]	LI Ying-xiu, ZHU Lian-de, ZHU Guo-yi, ZHAO Chun. A Chemiluminescence Optical Fiber Glucose Biosensor Based on Co-immobilizing Glucose Oxidase and Horseradish Peroxidase in a Sol-gel Film[J]. 高等学校化学研究, 2002, 18(1): 12-15.