Chemiluminescence Determination of Cefixime Trihydrate Based on Acidic Diperiodatoargentate(Ⅲ)-Rhodamine 6-G System

doi:10.1007/s40242-019-9073-x

摘要/Abstract

摘要： A novel chemiluminescence(CL) method is proposed for cefixime trihydrate(CFX) determination based on its enhancement effect on diperiodatoargentate(Ⅲ)(DPA)-rhodamine 6-G(Rh6-G) reaction in conjunction with flow injection analysis(FIA). A linear calibration curve was achieved over the range from 0.01 mg/L to 2.5 mg/L CFX(R²=0.999, n=8) with relative standard deviation(RSD) of 1.4%-3.8%(n=4)), limit of detection(LOD) of 3.0×10^-3 mg/L(S/N=3), injection throughput of 180/h and regression equation of y=1113.2x-14.596[y=CL intensity (mV) and x=concentration of CFX(mg/L)]. The method was successfully applied to CFX determination in pharmaceutical formulations and the recoveries(%) for proposed FI-CL and a reported spectrophotometric method by applying the Student t-test[calculated t-test value:t=1.079215, and tabulated t-distributed(95%)=2.200985] were not significantly different. The CFX was efficiently extracted and no significant effect of commonly found excipients in the pharmaceutical formulations was observed. The mechanism of CL reaction is discussed briefly.

关键词: Cefixime trihydrate, Diperiodatoargentate(III), Rhodamine 6-G, Chemiluminescence, Flow injection analysis, Pharmaceutical formulation

Abstract: A novel chemiluminescence(CL) method is proposed for cefixime trihydrate(CFX) determination based on its enhancement effect on diperiodatoargentate(Ⅲ)(DPA)-rhodamine 6-G(Rh6-G) reaction in conjunction with flow injection analysis(FIA). A linear calibration curve was achieved over the range from 0.01 mg/L to 2.5 mg/L CFX(R²=0.999, n=8) with relative standard deviation(RSD) of 1.4%-3.8%(n=4)), limit of detection(LOD) of 3.0×10^-3 mg/L(S/N=3), injection throughput of 180/h and regression equation of y=1113.2x-14.596[y=CL intensity (mV) and x=concentration of CFX(mg/L)]. The method was successfully applied to CFX determination in pharmaceutical formulations and the recoveries(%) for proposed FI-CL and a reported spectrophotometric method by applying the Student t-test[calculated t-test value:t=1.079215, and tabulated t-distributed(95%)=2.200985] were not significantly different. The CFX was efficiently extracted and no significant effect of commonly found excipients in the pharmaceutical formulations was observed. The mechanism of CL reaction is discussed briefly.

Key words: Cefixime trihydrate, Diperiodatoargentate(III), Rhodamine 6-G, Chemiluminescence, Flow injection analysis, Pharmaceutical formulation

MUHAMMAD Yousaf, MOHAMMED Yaqoob, MUHAMMAD Asghar, SAMAR Ali. Chemiluminescence Determination of Cefixime Trihydrate Based on Acidic Diperiodatoargentate(Ⅲ)-Rhodamine 6-G System[J]. 高等学校化学研究, 2019, 35(5): 775-781.

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