CuCl2/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides

doi:10.1007/s40242-018-8137-7

高等学校化学研究 ›› 2018, Vol. 34 ›› Issue (5): 727-731.doi: 10.1007/s40242-018-8137-7

CuCl₂/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides

YANG Jiuquan^1,2, WU Guojie², HE Yupeng¹, HAN Fushe²

1. College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, P. R. China;
2. Jilin Province Key Lab of Green Chemistry and Process, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

收稿日期:2018-04-28 修回日期:2018-05-21 出版日期:2018-10-01 发布日期:2018-06-19
通讯作者: WU Guojie,Email:gjwu@ciac.ac.cn;HE Yupeng,Email:yupeng.he@lnpu.edu.cn E-mail:gjwu@ciac.ac.cn;yupeng.he@lnpu.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(Nos.21572215, 21602215).

CuCl₂/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides

YANG Jiuquan^1,2, WU Guojie², HE Yupeng¹, HAN Fushe²

1. College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, P. R. China;
2. Jilin Province Key Lab of Green Chemistry and Process, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Received:2018-04-28 Revised:2018-05-21 Online:2018-10-01 Published:2018-06-19
Contact: WU Guojie,Email:gjwu@ciac.ac.cn;HE Yupeng,Email:yupeng.he@lnpu.edu.cn E-mail:gjwu@ciac.ac.cn;yupeng.he@lnpu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21572215, 21602215).

摘要/Abstract

摘要： A general and efficient coupling of aryl bromides with diethyl malonate is presented. The reaction provided the α-arylated diethyl malonates in moderate to good yields with a low loading of CuCl₂(5%, molar fraction) and 8-hydroxyquinoline(5%, molar fraction). This method has good compatibility for a wide range of aryl bromides.

关键词: Copper catalyst, α-Arylation, Malonate, Ullmann reaction, Hurtley reaction

Abstract: A general and efficient coupling of aryl bromides with diethyl malonate is presented. The reaction provided the α-arylated diethyl malonates in moderate to good yields with a low loading of CuCl₂(5%, molar fraction) and 8-hydroxyquinoline(5%, molar fraction). This method has good compatibility for a wide range of aryl bromides.

Key words: Copper catalyst, α-Arylation, Malonate, Ullmann reaction, Hurtley reaction

YANG Jiuquan, WU Guojie, HE Yupeng, HAN Fushe. CuCl₂/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides[J]. 高等学校化学研究, 2018, 34(5): 727-731.

YANG Jiuquan, WU Guojie, HE Yupeng, HAN Fushe. CuCl₂/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides[J]. Chemical Research in Chinese Universities, 2018, 34(5): 727-731.

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CuCl₂/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides

CuCl₂/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides

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