Ruthenium Coordination Compounds with Polypyridines ——Interaction of Ruthenium Polypyridine Complexes with Calf Thymus DNA —An Example of Non intercalative Binding

高等学校化学研究 ›› 1997, Vol. 13 ›› Issue (4): 283-288.

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Ruthenium Coordination Compounds with Polypyridines ——Interaction of Ruthenium Polypyridine Complexes with Calf Thymus DNA —An Example of Non intercalative Binding

YANG Guang¹, WANG Lei¹, WU Jian-zhong¹, ZENG Tian-xian¹, JI Liang-nian²

1. Department of Chemistry, Zhongshan University, Guangzhou 510275;
2. State Key Laboratory for OxaSynthesis and Selective Oxidation, Lanzhou Institution of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000

收稿日期:1996-08-26 出版日期:1997-12-24 发布日期:2011-08-17
基金资助:
Supported by the National Natural Science Foundation of China.

Ruthenium Coordination Compounds with Polypyridines ——Interaction of Ruthenium Polypyridine Complexes with Calf Thymus DNA —An Example of Non intercalative Binding

YANG Guang¹, WANG Lei¹, WU Jian-zhong¹, ZENG Tian-xian¹, JI Liang-nian²

1. Department of Chemistry, Zhongshan University, Guangzhou 510275;
2. State Key Laboratory for OxaSynthesis and Selective Oxidation, Lanzhou Institution of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000

Received:1996-08-26 Online:1997-12-24 Published:2011-08-17
Supported by:
Supported by the National Natural Science Foundation of China.

摘要/Abstract

摘要： Two new ruthenium polypyridine complexes, L₂RuL^'2+ (L represents 2,2'-bipyridine(bpy) or 1,10-phenanthroline(phen); L' represents Schiff base derived from 4,5-diazafluoren-9-one(AFO) and n-propylamine) have been prepared and characterized by means of elementary analyses, electronic absorption and IR spectra. The binding of the complexes to calf thymus DNA has been investigated via absorption, emission spectrometry, emission quenching, equilibrium dialysis and circular dichroism spectrometry. The experimental results show that these two complexes bind to calf thymus DNA by electrostatic mode and by non-ntercalative binding mode respectively.

关键词: Ruthenium, Polypyridine, Calf thymus DNA

Abstract: Two new ruthenium polypyridine complexes, L₂RuL^'2+ (L represents 2,2'-bipyridine(bpy) or 1,10-phenanthroline(phen); L' represents Schiff base derived from 4,5-diazafluoren-9-one(AFO) and n-propylamine) have been prepared and characterized by means of elementary analyses, electronic absorption and IR spectra. The binding of the complexes to calf thymus DNA has been investigated via absorption, emission spectrometry, emission quenching, equilibrium dialysis and circular dichroism spectrometry. The experimental results show that these two complexes bind to calf thymus DNA by electrostatic mode and by non-ntercalative binding mode respectively.

Key words: Ruthenium, Polypyridine, Calf thymus DNA

YANG Guang, WANG Lei, WU Jian-zhong, ZENG Tian-xian, JI Liang-nian . Ruthenium Coordination Compounds with Polypyridines ——Interaction of Ruthenium Polypyridine Complexes with Calf Thymus DNA —An Example of Non intercalative Binding[J]. 高等学校化学研究, 1997, 13(4): 283-288.

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Ruthenium Coordination Compounds with Polypyridines ——Interaction of Ruthenium Polypyridine Complexes with Calf Thymus DNA —An Example of Non intercalative Binding

Ruthenium Coordination Compounds with Polypyridines ——Interaction of Ruthenium Polypyridine Complexes with Calf Thymus DNA —An Example of Non intercalative Binding

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