Analysis of Peptide Ligand Binding to FGFR1

高等学校化学研究 ›› 2003, Vol. 19 ›› Issue (1): 41-43.

Analysis of Peptide Ligand Binding to FGFR1

FAN Hong-kuan¹, DUAN Yan-fen¹, ZHOU Hui¹, LI Fei², LI Wei¹

1. College of Life Science, Jilin University, Changchun 130023, P. R. China;
2. College of Life Science, Supra Molecular Structure and Spectroscopy of Ministry of Education, Jilin University, Changchun 130023, P. R. China

收稿日期:2001-04-13 出版日期:2003-01-24 发布日期:2011-08-06
基金资助:
Supported by a grant from the National Natural Science Foundation of China(No.30070892).

Analysis of Peptide Ligand Binding to FGFR1

FAN Hong-kuan¹, DUAN Yan-fen¹, ZHOU Hui¹, LI Fei², LI Wei¹

1. College of Life Science, Jilin University, Changchun 130023, P. R. China;
2. College of Life Science, Supra Molecular Structure and Spectroscopy of Ministry of Education, Jilin University, Changchun 130023, P. R. China

Received:2001-04-13 Online:2003-01-24 Published:2011-08-06
Supported by:
Supported by a grant from the National Natural Science Foundation of China(No.30070892).

摘要/Abstract

摘要： Simulating annealing algorithm was used in docking computation to predict a selected peptide VYMSPF(P2) binding site on the ectodomain of FGFR1. The peptide is located on the hydrophobic surface of the receptor, which is critical for FGF binding. The synthesized peptide can effectively inhibit the mitogenic activity of aFGF, and has a potential to become a therapeutic agent as an aFGF antagonist.

关键词: Fibroblast growth factor, Inhibitor, Docking, Simulating annealing algorithm

Abstract: Simulating annealing algorithm was used in docking computation to predict a selected peptide VYMSPF(P2) binding site on the ectodomain of FGFR1. The peptide is located on the hydrophobic surface of the receptor, which is critical for FGF binding. The synthesized peptide can effectively inhibit the mitogenic activity of aFGF, and has a potential to become a therapeutic agent as an aFGF antagonist.

Key words: Fibroblast growth factor, Inhibitor, Docking, Simulating annealing algorithm

FAN Hong-kuan, DUAN Yan-fen, ZHOU Hui, LI Fei, LI Wei. Analysis of Peptide Ligand Binding to FGFR1[J]. 高等学校化学研究, 2003, 19(1): 41-43.

FAN Hong-kuan, DUAN Yan-fen, ZHOU Hui, LI Fei, LI Wei. Analysis of Peptide Ligand Binding to FGFR1[J]. Chemical Research in Chinese Universities, 2003, 19(1): 41-43.

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Analysis of Peptide Ligand Binding to FGFR1

Analysis of Peptide Ligand Binding to FGFR1

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