Synthesis of γ-Substituted Alcohol with Polymer-bound Amide

高等学校化学研究 ›› 2004, Vol. 20 ›› Issue (2): 142-145.

Synthesis of γ-Substituted Alcohol with Polymer-bound Amide

REN Jun, HUANG Jin-xia, LI Yan, ZHOU Yuan-yuan

Faculty of Chemistry and Material Science, Hubei University, Wuhan 430062, P. R. China

收稿日期:2003-02-22 出版日期:2004-04-24 发布日期:2011-08-06
基金资助:
Supported by the National Natural Science Foundation of China(No.29872012).

Synthesis of γ-Substituted Alcohol with Polymer-bound Amide

REN Jun, HUANG Jin-xia, LI Yan, ZHOU Yuan-yuan

Faculty of Chemistry and Material Science, Hubei University, Wuhan 430062, P. R. China

Received:2003-02-22 Online:2004-04-24 Published:2011-08-06
Supported by:
Supported by the National Natural Science Foundation of China(No.29872012).

摘要/Abstract

摘要： With solid phase organic synthesis method(SPOS), polymer-bound N-enoylprolinol(4) was prepared by the attachment of N-enoylprolinol(3) to Merrifield resin and was used for asymmetric Michael additions for the first time. The enantiomeric excess obtained by this method is increased as compared with that obtained by the corresponding solution phase reactions.

关键词: Polymer-bound, Asymmetric Michael addition, &gamma, -Substituted alcohol

Abstract: With solid phase organic synthesis method(SPOS), polymer-bound N-enoylprolinol(4) was prepared by the attachment of N-enoylprolinol(3) to Merrifield resin and was used for asymmetric Michael additions for the first time. The enantiomeric excess obtained by this method is increased as compared with that obtained by the corresponding solution phase reactions.

Key words: Polymer-bound, Asymmetric Michael addition, γ-Substituted alcohol

REN Jun, HUANG Jin-xia, LI Yan, ZHOU Yuan-yuan. Synthesis of γ-Substituted Alcohol with Polymer-bound Amide[J]. 高等学校化学研究, 2004, 20(2): 142-145.

REN Jun, HUANG Jin-xia, LI Yan, ZHOU Yuan-yuan. Synthesis of γ-Substituted Alcohol with Polymer-bound Amide[J]. Chemical Research in Chinese Universities, 2004, 20(2): 142-145.

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Synthesis of γ-Substituted Alcohol with Polymer-bound Amide

Synthesis of γ-Substituted Alcohol with Polymer-bound Amide

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